{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:17:14Z","timestamp":1791497834628,"version":"4.3.4"},"reference-count":19,"publisher":"Mark Allen Group","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Wound Care"],"published-print":{"date-parts":[[2017,12,2]]},"abstract":"<jats:sec><jats:title>Objective:<\/jats:title><jats:p> Platelet-rich plasma (PRP) has been proposed as an adjunct for the treatment of foot ulcers in patients with diabetes, as well as a treatment for chronic and acute wounds. This study examined the application of PRP in the treatment of diabetic foot ulcers (DFUs) in patients. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> This prospective study was conducted between 2011 and 2014. We used PRP, produced by a kit, for the treatment of DFUs. Patients were allocated to one of three groups, according to size of ulcer. The significance of changes in time for wound healing were statistically assessed. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> The study was completed by 150 patients, and a total of 150 foot ulcers were assessed. Wound size reduction was detected in patients after four weeks of treatment. In DFUs with a 2\u20135.5 cm<jats:sup>2<\/jats:sup> surface area, complete closure happened after 7.2 weeks, 5.5\u20138.5cm<jats:sup>2<\/jats:sup> DFUs completely closed after 7.5 weeks, and 8.5\u201312.5cm<jats:sup>2<\/jats:sup> DFUs healed completely after 8.8 weeks. None of the wounds reopened after eight months of monitoring. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p> This study will provide more evidence for the use of autologous PRP for DFUs in patients. <\/jats:p><\/jats:sec>","DOI":"10.12968\/jowc.2017.26.12.784","type":"journal-article","created":{"date-parts":[[2017,12,16]],"date-time":"2017-12-16T00:58:24Z","timestamp":1513385904000},"page":"784-787","source":"Crossref","is-referenced-by-count":65,"title":["Management of chronic diabetic foot ulcers using platelet-rich plasma"],"prefix":"10.12968","volume":"26","author":[{"given":"V.","family":"Babaei","sequence":"first","affiliation":[{"name":"Laboratory Attendant, Department of Medical Genetics, Iran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Afradi","sequence":"additional","affiliation":[{"name":"Physician in Charge, Baharloo Hospital, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.Z.","family":"Gohardani","sequence":"additional","affiliation":[{"name":"Lab Attendant, Iranian Blood Transfusion Organization, Zafar Clinic, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Nasseri","sequence":"additional","affiliation":[{"name":"Physician, Shahid Rajaee Hospital, Alborz University of Medical Sciences, Karaj, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Azarafza","sequence":"additional","affiliation":[{"name":"Lab Attendant, Department of Immunology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Teimourian","sequence":"additional","affiliation":[{"name":"Associate Professor, Department of Medical Genetics, Iran University of Medical Sciences, Tehran, Iran; 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