{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T19:32:26Z","timestamp":1793043146868,"version":"4.5.0"},"reference-count":23,"publisher":"Mark Allen Group","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Wound Care"],"published-print":{"date-parts":[[2017,2,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The aim of this study was to evaluate the clinical and histopathological effects of two different dosages of alcohol extract of Tarantula cubensis (Theranekron) on open wounds.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method:<\/jats:title>\n                    <jats:p>A total of 24 Sprague-Dawley rats were randomly divided into Tarantula cubensis extract (TCE1, n=8) 1\/10 diluted, TCE (TCE2, n=8), and (3) vehicle-control (0.2 ml of 96 % ethanol, n=8) groups. Experimental full-thickness 1 x 1cm wounds were created on dorsum skin. TCE or vehicle were given systemically by subcutaneous injections on postoperative days 1 and 4. Wound planimetry and procurement of biopsies was performed on days 4, 8, 12 and 16.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The mean non-epithelialised wound area in the vehicle-control group was significantly larger than in the TCE1 group on days 4, 8, 12 and 16, and in the TCE2 group on days 8, 12 and 16 (p&lt;0.05). The mean percentage of wound contraction was significantly higher in the TCE1 and TCE2 groups than in the vehicle control group on days 8, 12 and 16 (p&lt;0.05). Histopathologically, wound healing was characterised by a significant decrease in the neutrophil counts and a significant increase in neovascularisation; neither were effected by TCE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Our results suggest that alcohol extract of Tarantula cubensis accelerates epithelialisation and, thus, has beneficial effects on open wound healing in rats.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.12968\/jowc.2017.26.2.66","type":"journal-article","created":{"date-parts":[[2017,2,9]],"date-time":"2017-02-09T13:07:16Z","timestamp":1486645636000},"page":"66-71","source":"Crossref","is-referenced-by-count":21,"title":["The effects of\n                    <i>Tarantula cubensis<\/i>\n                    venom on open wound healing in rats"],"prefix":"10.12968","volume":"26","author":[{"given":"N.Y.","family":"Gul Satar","sequence":"first","affiliation":[{"name":"Professor, Dr; Department of Surgery Uludag University, 16059, Nilufer\/Bursa, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.T.","family":"Cangul","sequence":"additional","affiliation":[{"name":"Assistant Professor, Dr; Department of Pathology, Uludag University, 16059, Nilufer\/Bursa, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Topal","sequence":"additional","affiliation":[{"name":"Professor, Dr; Department of Surgery Uludag University, 16059, Nilufer\/Bursa, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Kurt","sequence":"additional","affiliation":[{"name":"DVM, Research Assistant, Department of Surgery Uludag University, 16059, Nilufer\/Bursa, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Ipek","sequence":"additional","affiliation":[{"name":"DVM, Research Assistant, Department of Pathology, Uludag University, 16059, Nilufer\/Bursa, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.I.","family":"Onel","sequence":"additional","affiliation":[{"name":"DVM, Faculty of Veterinary, Medicine, Uludag University, 16059, Nilufer\/Bursa, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5130","reference":[{"key":"B1","first-page":"13","volume":"2","author":"Gultekin N.","year":"2007","journal-title":"J Istanbul Vet Sci"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3923\/javaa.2012.3258.3261"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1136\/vr.160.14.486"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3923\/ajava.2011.744.749"},{"key":"B5","first-page":"424","volume":"61","author":"Koch V.H.","year":"1980","journal-title":"Prakt Tierarzt"},{"key":"B6","volume-title":"Proceedings of the VIIth National Veterinary Internal Medicine Congress","author":"Lotfollahzadeh S."},{"issue":"4","key":"B7","first-page":"593","volume":"16","author":"Albay M.K.","year":"2010","journal-title":"Kafkas Univ Vet Fak Derg"},{"key":"B8","first-page":"116","volume":"61","author":"Koch V.H.","year":"1980","journal-title":"Prakt Tierarzt"},{"key":"B9","first-page":"91","volume":"57","author":"Stampa S.","year":"1986","journal-title":"J S Afr Vet Assoc"},{"key":"B10","first-page":"47","volume":"8","author":"Hatipoglu S.","year":"1996","journal-title":"Turk Vet Hek Dern Der"},{"key":"B11","volume-title":"Complementary and Alternative Veterinary Medicine","author":"Day C.","year":"1998"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1054\/homp.2002.0029"},{"issue":"1","key":"B13","first-page":"11","volume":"13","author":"Kacar C.","year":"2007","journal-title":"Kafkas Univ Vet Fak Derg"},{"key":"B14","first-page":"534","volume":"88","author":"Enbergs H.","year":"2007","journal-title":"Prakt Tierarzt"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1007\/s00580-006-0657-8"},{"key":"B16","first-page":"519","volume":"29","author":"Swaim S.F.","year":"1993","journal-title":"J Am Anim Hosp Assoc"},{"issue":"2","key":"B17","first-page":"9","volume":"3","author":"Sardari K.","year":"2011","journal-title":"Iran J Vet Sci Tech"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2006.00551.x"},{"issue":"1","key":"B19","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/j.1365-3164.2007.00647.x","volume":"19","author":"Gul N.Y.","year":"2008","journal-title":"Vet Dermatol"},{"key":"B20","first-page":"545","volume":"20","author":"Gul Satar N.Y.","year":"2014","journal-title":"Kafkas Univ Vet Fak Derg"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1111\/j.0906-6705.2003.00087.x"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.67.909"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2005.09.012"}],"container-title":["Journal of Wound Care"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/pdf\/10.12968\/jowc.2017.26.2.66","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,22]],"date-time":"2024-06-22T07:34:19Z","timestamp":1719041659000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/10.12968\/jowc.2017.26.2.66"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,2]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,2,2]]}},"alternative-id":["10.12968\/jowc.2017.26.2.66"],"URL":"https:\/\/doi.org\/10.12968\/jowc.2017.26.2.66","relation":{},"ISSN":["0969-0700","2052-2916"],"issn-type":[{"value":"0969-0700","type":"print"},{"value":"2052-2916","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,2]]}}}