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The range comprises Mepilex Ag, Mepilex Border Ag and Mepilex Transfer Ag. <\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p> A literature review was undertaken to identify and summarise clinical data from the entire evidence hierarchy, as well as data from in vitro tests, which support the use of silver-containing foam dressings with Safetac. <\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p> The MEDLINE (National Library of Medicine, Bethesda, US) and EMBASE (Elsevier BV, Amsterdam, Netherlands) bibliographic databases were searched. In addition, abstract books and proceedings documents relating to national and international conferences were scanned in order to identify presentations (oral, e-poster and poster) of relevance to the review. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> In vitro test results showed that the silver-containing foam dressings with Safetac have both rapid and sustained activity against a range of wound pathogens, reducing planktonic and established biofilm cultures, and preventing biofilm formation. In numerous clinical studies, silvercontaining foam dressings with Safetac were used to manage wound bioburden effectively and resolve signs of localised infection in both acute wounds (such as surgical, traumatic and burn injuries) and chronic wounds (such as leg ulcers, pressure ulcers (PUs), diabetic foot ulcers (DFUs), and cancerous wounds). Studies reported that silver-containing foam dressings with Safetac are easy to use, provide an optimal environment for wound healing, and are associated with atraumatic and virtually painfree removal. As well as being clinically effective, they are reported to be cost-effective when used on wounds that require topical antimicrobial therapy. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> The findings of both scientific and clinical studies clearly indicate that clinical, patient-related and economic benefits are associated with the use of Mepilex Ag, Mepilex Border Ag and Mepilex Transfer Ag with Safetac in the treatment of wounds where antimicrobial activity is needed to help manage bioburden. <\/jats:p><\/jats:sec>","DOI":"10.12968\/jowc.2017.26.sup6a.s1","type":"journal-article","created":{"date-parts":[[2017,6,8]],"date-time":"2017-06-08T15:09:52Z","timestamp":1496934592000},"page":"S1-S32","source":"Crossref","is-referenced-by-count":46,"title":["Silver-containing foam dressings with Safetac: a review of the scientific and clinical data"],"prefix":"10.12968","volume":"26","author":[{"given":"Phil","family":"Davies","sequence":"first","affiliation":[{"name":"M\u00f6lnlycke Health Care"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"McCarty","sequence":"additional","affiliation":[{"name":"M\u00f6lnlycke Health Care"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Hamberg","sequence":"additional","affiliation":[{"name":"M\u00f6lnlycke Health Care"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5130","reference":[{"key":"p_5","volume-title":"aureus","author":"Organisation S."},{"key":"p_11","unstructured":"(2015)74"},{"key":"p_13","unstructured":"n Deep partialthickness thermal burn injuries (TBSA 2.5-25%) (n=153)"},{"key":"p_14","volume-title":"Mepilex Ag (n=71)","author":"Treatment"},{"key":"p_27","volume-title":"34","year":"2011"},{"key":"p_29","unstructured":"n Partial-thickness injuries <36 hours post-burn (TBSA: 2.5-20%) (n=100)"},{"key":"p_30","volume-title":"Mepilex Ag (n=49)","author":"Treatment"},{"key":"p_85","volume-title":"77 Superficial partial","author":"Sivertsen","year":"2011"},{"key":"p_92","volume-title":"86 Chronic leg ulcers (n=2) Up to 77","author":"Barrett","year":"2009"},{"key":"p_94","volume-title":"82 Acute\/chronic wounds","author":"Barrows","year":"2009"},{"key":"p_96","volume-title":"113 Chronic wounds (n=10) Not stated \u2022 \u2022 \u2022 \u2022 \u2022","author":"Cuvelier","year":"2009"},{"key":"p_97","volume-title":"105 DFUs (n=4) Up to 112","author":"Tong","year":"2009"},{"key":"p_98","volume-title":"114 Acute\/chronic wounds","author":"Beer","year":"2008"},{"key":"p_101","unstructured":"(2008)115DFUs (n=3) Not stated \u2022 \u2022 \u2022 \u2022 \u2022 \u2022"},{"key":"p_103","unstructured":"(2008)116Chronic wounds (n=24) Not stated \u2022 \u2022 \u2022 \u2022"},{"key":"p_105","unstructured":"(2008)117Chronic wounds (n=7) Not stated \u2022 \u2022 \u2022 \u2022 \u2022"},{"key":"p_106","volume-title":"104 VLUs (n=5) Up to 28","author":"Kheng","year":"2008"},{"key":"p_108","unstructured":"(2008)118Chronic painful leg ulcers (n=2) 20 days \u2022 \u2022 \u2022 \u2022"},{"key":"p_109","volume-title":"84 Acute\/chronic wounds","author":"Nisbet","year":"2008"},{"key":"p_112","volume-title":"106 DFU 49 days \u2022 \u2022 \u2022 \u2022","author":"Mir","year":"2013"},{"key":"p_114","unstructured":"(2011)78Paediatric partial-thickness burn Not stated \u2022 \u2022 \u2022 \u2022"},{"key":"p_115","volume-title":"123 Infected toe wound 11 days \u2022 \u2022 \u2022","author":"Rivas","year":"2008"},{"key":"p_117","unstructured":"(2008)124DFU 56 days \u2022 \u2022"},{"key":"p_125","unstructured":"patients (n=18) with VLUs (n=11), ulcers of mixed arterial\/venous Kles et al. 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