{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T03:04:15Z","timestamp":1788923055431,"version":"build-2803163510"},"reference-count":26,"publisher":"Mark Allen Group","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Wound Care"],"published-print":{"date-parts":[[2018,2,2]]},"abstract":"<jats:sec><jats:title>Objective:<\/jats:title><jats:p> To estimate whether collagen-containing dressings could potentially afford the UK's National Health Service (NHS) a cost-effective intervention for the management of non-healing venous leg ulcers (VLUs). <\/jats:p><\/jats:sec><jats:sec><jats:title>Method:<\/jats:title><jats:p> This was a modelling study performed from the perspective of the UK's NHS. A combination of published clinical outcomes, resource utilisation estimates and utilities for VLUs enabled the construction of a decision model, depicting the management of a chronic VLU with standard care or with a collagen-containing dressing plus compression therapy followed by standard care, over a period of 6 months. The model estimated the incremental cost-effectiveness of the two interventions in terms of the incremental cost per quality-adjusted life year (QALY) gained at 2015\/16 prices. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> The treatment of VLUs of &gt;6 months' duration with a collagen-containing dressing plus compression therapy followed by standard care, instead of standard care, is expected to increase the probability of healing from 0.11 to 0.49 by 6 months and increase health-related quality of life at 6 months from 0.331 to 0.373 QALYs per patient. Additionally, treatment with a collagen-containing dressing plus compression therapy followed by standard care has the potential to reduce management costs by 40% over 6 months when compared with standard care (from \u00a36328 to \u00a33789 per patient). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> Within the study's limitations, including a collagen-containing dressing into a standard care protocol compared with standard care potentially affords the NHS a cost-effective (dominant) treatment since it improves outcomes for less cost. <\/jats:p><\/jats:sec>","DOI":"10.12968\/jowc.2018.27.2.68","type":"journal-article","created":{"date-parts":[[2018,2,9]],"date-time":"2018-02-09T13:48:36Z","timestamp":1518184116000},"page":"68-78","source":"Crossref","is-referenced-by-count":9,"title":["Cost-effectiveness of using a collagen-containing dressing plus compression therapy in non-healing venous leg 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