{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:16:16Z","timestamp":1790270176232,"version":"4.1.0"},"reference-count":12,"publisher":"Mark Allen Group","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Wound Care"],"published-print":{"date-parts":[[2018,5,2]]},"abstract":"<jats:sec><jats:title>Objective:<\/jats:title><jats:p> This case series evaluates the safety and effectiveness of 3D-printed scaffold in chronic wounds. The scaffold is a composite of natural and synthetic materials, and can be prepared in the form of powder or membrane. <\/jats:p><\/jats:sec><jats:sec><jats:title>Method:<\/jats:title><jats:p> We recruited patients with pressure ulcera (PU) and\/or a diabetic foot ulcers (DFU). We used two methods: 3D-printed scaffolds alone, or 3D-printing powder mixed with platelet-rich fibrinogen (PRF). Clinicians and patients were asked to rate the scaffold's ease of application and comfort during use. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> A total of five patients were recruited; four with a PU and one with a DFU. For the patient treated with the 3D-printed scaffold membrane (n=1), their PU healed in 28 days, and for patients treated with the 3D-printed scaffold powder (n=2), their PUs healed in 54 days. For the patients treated with the 3D-printing powder mixed with PRF (n=2), the patient with a PU healed in 11 days, and the patient with the DFU healed in 14 days. All clinicians rated the 3D-printed scaffold as \u2018easy\u2019 or \u2018very easy\u2019 to use, and patients rated their comfort during wear and at dressing change as \u2018good\u2019 or \u2018very good\u2019. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> This study demonstrated that 3D-printed scaffold was convenient to use, have the potential to improve wound healing rates, and provided a safe and effective way for treating chronic wounds. <\/jats:p><\/jats:sec>","DOI":"10.12968\/jowc.2018.27.5.262","type":"journal-article","created":{"date-parts":[[2018,5,8]],"date-time":"2018-05-08T17:48:28Z","timestamp":1525801708000},"page":"262-271","source":"Crossref","is-referenced-by-count":23,"title":["Clinical application of a 3D-printed scaffold in chronic wound treatment: a case series"],"prefix":"10.12968","volume":"27","author":[{"given":"Haining","family":"Sun","sequence":"first","affiliation":[{"name":"Chief physician; Chronic Wound Care Center, Hangzhou Geriatric Hospital, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huayao","family":"Lv","sequence":"additional","affiliation":[{"name":"Attending physician; Chronic Wound Care Center, Hangzhou Geriatric Hospital, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanghui","family":"Qiu","sequence":"additional","affiliation":[{"name":"Attending physician; Geriatric Care Center, Hangzhou Geriatric Hospital, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duolun","family":"Sun","sequence":"additional","affiliation":[{"name":"Attending physician; Geriatric Care Center, Hangzhou Geriatric Hospital, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Gao","sequence":"additional","affiliation":[{"name":"Chief physician; Geriatric Care Center, Hangzhou Geriatric Hospital, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Chen","sequence":"additional","affiliation":[{"name":"Chief physician; Geriatric Care Center, Hangzhou Geriatric Hospital, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YongKe","family":"Zheng","sequence":"additional","affiliation":[{"name":"Associate chief physician; Geriatric Care Center, Hangzhou Geriatric Hospital, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunxue","family":"Deng","sequence":"additional","affiliation":[{"name":"Head of Research and Development Department; Department of Mechanical Engineering, University of Texas at El Paso, El Paso, US; Medprin Institute of Technology, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaya","family":"Yang","sequence":"additional","affiliation":[{"name":"Research and development engineer; Multidisciplinary Research Center, Shantou University, Shantou, China; Medprin Institute of Technology, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haitao","family":"Zhang","sequence":"additional","affiliation":[{"name":"R&D Engineer; Key Laboratory of Advanced Textile Materials and Manufacturing Technology of Ministry of Education, Zhejiang Sci-Tech University, Hangzhou, China; Medprin Institute of Technology, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Xu","sequence":"additional","affiliation":[{"name":"Professor of 3D Bio-printing, Tissue engineering and regenerative medicine; Department of Mechanical Engineering, University of Texas at El Paso, El Paso, US; Bio-manufacturing Center, Department of Mechanical Engineering, Tsinghua University, Beijing, China; Department of Precision Medicine and Healthcare, Tsinghua-Berkeley Shenzhen Institute, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongni","family":"Ren","sequence":"additional","affiliation":[{"name":"Research and development engineer; Medprin Institute of Technology, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5130","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2005.07.011"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1080\/01616412.2016.1214418"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1111\/aor.12568"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1080\/01616412.2017.1348680"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2005.07.008"},{"key":"B8","first-page":"5","volume":"68","author":"Situm M","year":"2014","journal-title":"Acta Medica Croatica"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1177\/0363546509349921"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(98)90029-4"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2007.01108.x"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.4103\/0972-124X.145821"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jobcr.2014.03.003"},{"issue":"1","key":"B14","first-page":"55","volume":"19","author":"Soadoun AP","year":"2007","journal-title":"Pract Proced Aesthet Dent"}],"container-title":["Journal of Wound Care"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/pdf\/10.12968\/jowc.2018.27.5.262","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,24]],"date-time":"2022-05-24T20:33:44Z","timestamp":1653424424000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/10.12968\/jowc.2018.27.5.262"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,2]]},"references-count":12,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,5,2]]}},"alternative-id":["10.12968\/jowc.2018.27.5.262"],"URL":"https:\/\/doi.org\/10.12968\/jowc.2018.27.5.262","relation":{},"ISSN":["0969-0700","2052-2916"],"issn-type":[{"value":"0969-0700","type":"print"},{"value":"2052-2916","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,2]]}}}