{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T06:20:16Z","timestamp":1790317216036,"version":"4.1.0"},"reference-count":26,"publisher":"Mark Allen Group","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Wound Care"],"published-print":{"date-parts":[[2018,7,2]]},"abstract":"<jats:sec><jats:title>Objective:<\/jats:title><jats:p> Oxygen plays a central role in wound healing. Recent technological advances have miniaturised oxygen delivery systems, with novel topical oxygen therapy allowing patients to receive oxygen therapy 24 hours a day while remaining completely mobile. Here we aim to examine the efficacy and safety of continuous topical oxygen diffusion in a \u2018real-world\u2019 setting. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> Topical oxygen therapy (TOT) was evaluated in patients with chronic, non-healing wounds in a tertiary referral specialist clinic. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> The mean wound duration before TOT was 15 months. Regardless of treatment duration, in this previously non-healing group complete wound closure was observed in 32% of the total patients treated with the TOT device. However, optimal wound healing occurred when the device was used for &gt;25 days, with an 83% wound area reduction and 47% wound closure rate seen in venous leg ulcers (VLUs) and a 74% reduction and a 57% wound closure rate in arterial foot ulcers. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> Use of TOT in chronic wounds stimulates a healing state. In our study, almost half of the previously non-healing wounds closed. <\/jats:p><\/jats:sec>","DOI":"10.12968\/jowc.2018.27.7.426","type":"journal-article","created":{"date-parts":[[2018,7,17]],"date-time":"2018-07-17T16:45:33Z","timestamp":1531845933000},"page":"426-433","source":"Crossref","is-referenced-by-count":51,"title":["Topical oxygen therapy stimulates healing in difficult, chronic wounds: a tertiary centre experience"],"prefix":"10.12968","volume":"27","author":[{"given":"Hanna","family":"Kaufman","sequence":"first","affiliation":[{"name":"Head of Department; 1Northern District Trauma & Wound Clinics Division, \u201cMaccabi\u201d Health Care Services"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxim","family":"Gurevich","sequence":"additional","affiliation":[{"name":"Hillel Yaffe Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eran","family":"Tamir","sequence":"additional","affiliation":[{"name":"Orthopaedic Surgeon; Department of Orthopaedic Surgery, Assaf HaRofeh Medical Center, Zerrifin, Affiliated to the Sackler School of Medicine, Tel Aviv University, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elad","family":"Keren","sequence":"additional","affiliation":[{"name":"Orthopaedic Surgeon; Maccabi healthcare services Beer Sheva. 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