{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:06:19Z","timestamp":1787238379654,"version":"build-2736575974"},"reference-count":33,"publisher":"Mark Allen Group","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Wound Care"],"published-print":{"date-parts":[[2019,10,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Pain is a common and disabling symptom in patients with leg ulcers. Clinical quantification of pain mostly depends on subjective pain reports, which do not reveal underlying mechanisms. The aim of this pilot study is to identify mechanisms underlying the pain in patients with leg ulcers by documenting alterations in pain processing using quantitative sensory testing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In nine ulcer patients the mechanical sensory thresholds and the mechanical pain thresholds were determined by Semmes-Weinstein monofilaments (SWM) at three different sites: on the contralateral (unaffected) leg, on the skin of the affected leg 10cm from the ulcer margin, and on the affected leg, close (1\u20132cm) to the ulcer margin. Besides the mechanical sensory thresholds and mechanical pain thresholds, pain at the site of the ulcer, using an 11-point numeric rating scale (NRS), was documented.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Mechanical sensory thresholds were increased in all subjects. Almost half (44%) of patients consistently showed allodynia at the unaffected site. The lowering of mechanical pain thresholds correlated with higher scores on the NRS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>All patients showed diminished touch and\/or protective sensation, which might have contributed to ulcer development via (partial) loss of protective function. The allodynia at the unaffected site suggests the presence of central sensitisation of pain processing.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.12968\/jowc.2019.28.10.647","type":"journal-article","created":{"date-parts":[[2019,10,10]],"date-time":"2019-10-10T13:28:08Z","timestamp":1570714088000},"page":"647-655","source":"Crossref","is-referenced-by-count":3,"title":["Measuring sensory and pain thresholds by Semmes-Weinstein monofilaments in patients with leg ulcers: a pilot study"],"prefix":"10.12968","volume":"28","author":[{"given":"Mark MPM","family":"Jansen","sequence":"first","affiliation":[{"name":"Midden-Brabant Hospital Pharmacy, Elisabeth TweeSteden Hospital Tilburg, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aukje ALM","family":"van de Ven","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Radboudumc, Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter GM","family":"van der Valk","sequence":"additional","affiliation":[{"name":"Department of Dermatology, van Weel-Bethesda Hospital, Dirksland, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver HG","family":"Wilder-Smith","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Pain and Palliative Medicine, Radboudumc, Nijmegen, The Netherlands"},{"name":"Center for Sensory-Motor Interaction, Department of Health Sciences, Aalborg University, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5130","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/S1047-2797(01)00255-1"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2702.2003.00859.x"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-001-0078-y"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aen088"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijnurstu.2006.05.001"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2010.04654.x"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1017\/S1463423611000302"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2702.2004.01090.x"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1097\/00152192-199509000-00007"},{"issue":"2","key":"B10","first-page":"S18, S20, S22","volume":"20","author":"Taverner T","year":"2011","journal-title":"Br J Nurs"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2007.00203.x"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-016-0198-1"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aen103"},{"key":"B14","unstructured":"International Association for the Study of Pain (IASP). Classification of chronic pain. description of chronic pain syndromes and definitions of pain terms 2nd Ed. Merskey H, Bogduk N (eds). IASP, 1994"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.2217\/pmt.14.8"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1097\/01.ajp.0000210950.01503.72"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0b013e3181673b80"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1097\/00004691-199701000-00003"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1097\/00004691-199411000-00004"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20053"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.2337\/db13-0352"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1497.1999.05208.x"},{"issue":"1","key":"B23","first-page":"16","volume":"4","author":"Plucknette B","year":"2012","journal-title":"J Diabet Foot Complications"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1177\/000331979604700605"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2006.04.011"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1126\/science.288.5472.1765"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i1.47"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1097\/01.j.pain.0000460343.46847.58"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2004.02456.x"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12475"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/119.5.1449"},{"key":"B32","author":"Yarnitsky D","year":"2014","journal-title":"Eur J Pain"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2006.01.041"}],"container-title":["Journal of Wound Care"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/pdf\/10.12968\/jowc.2019.28.10.647","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,24]],"date-time":"2022-05-24T19:25:58Z","timestamp":1653420358000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/10.12968\/jowc.2019.28.10.647"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,2]]},"references-count":33,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019,10,2]]}},"alternative-id":["10.12968\/jowc.2019.28.10.647"],"URL":"https:\/\/doi.org\/10.12968\/jowc.2019.28.10.647","relation":{},"ISSN":["0969-0700","2052-2916"],"issn-type":[{"value":"0969-0700","type":"print"},{"value":"2052-2916","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,2]]}}}