{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,5,24]],"date-time":"2022-05-24T23:40:52Z","timestamp":1653435652357},"reference-count":19,"publisher":"Mark Allen Group","issue":"Sup2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Wound Care"],"published-print":{"date-parts":[[2019,2,1]]},"abstract":"<jats:sec><jats:title>Objective:<\/jats:title><jats:p> There is a medical need to evaluate new treatments that may improve wound healing. This study aimed to determine if Original Healing Salve (OHS, Puremedy, Inc.) a topical, botanically-enriched salve (BES), changes distal leg tissue oxygenation in people with type 2 diabetes. <\/jats:p><\/jats:sec><jats:sec><jats:title>Method:<\/jats:title><jats:p> A randomised, controlled, crossover, double-blinded clinical trial comparing changes in cutaneous oxygen delivery (mean TcPO<jats:sub>2<\/jats:sub>) on multiple sites of the lower extremity following application of a botanically-enriched topical salve, as compared with application of the salve's base in patients with type 2 diabetes. Subjects were recruited from the general population as a convenience sample. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> A total of 16 participants were recruited. Analysis of the primary outcome demonstrated no statistically significant difference in TcPO<jats:sub>2<\/jats:sub> at 30 minutes postapplication when comparing the BES to the base salve (BS) on the leg (\u20130.39\u00b18.54mmHg; p=0.86). Analyses of secondary outcomes at 30 minutes postapplication indicated that mean TcPO<jats:sub>2<\/jats:sub> was significantly higher than preapplication levels among subjects receiving both the BES (3.70\u00b16.62mmHg; p=0.04) and BS on the leg (4.08\u00b15.21mmHg; p=0.007). On the foot, mean TcPO<jats:sub>2<\/jats:sub> at 30 minutes postapplication was higher in the BES compared with the BS, this difference was not significant (0.98\u00b18.59mmHg; p=0.66). Mean TcPO<jats:sub>2<\/jats:sub> was higher than preapplication levels among subjects receiving both the BES (1.21\u00b17.70mmHg; p=0.54) and BS on the foot (2.19\u00b17.27mmHg; p=0.25). These differences were non-significant. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> These findings support consideration of topical treatments containing botanical ingredients to increase cutaneous oxygen delivery in the lower extremity in patients with type 2 diabetes. <\/jats:p><\/jats:sec>","DOI":"10.12968\/jowc.2019.28.sup2.s16","type":"journal-article","created":{"date-parts":[[2019,2,15]],"date-time":"2019-02-15T11:51:52Z","timestamp":1550231512000},"page":"S16-S22","source":"Crossref","is-referenced-by-count":0,"title":["Effects of a topical botanically-enriched salve on cutaneous oxygenation"],"prefix":"10.12968","volume":"28","author":[{"given":"Jamie","family":"Corroon","sequence":"first","affiliation":[{"name":"Helfgott Research Institute, National University of Natural Medicine, Portland, US"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Erlandsen","sequence":"additional","affiliation":[{"name":"Helfgott Research Institute, National University of Natural Medicine, Portland, US"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Taylor","sequence":"additional","affiliation":[{"name":"Helfgott Research Institute, National University of Natural Medicine, Portland, US"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doug","family":"Hanes","sequence":"additional","affiliation":[{"name":"Helfgott Research Institute, National University of Natural Medicine, Portland, US"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan","family":"Bradley","sequence":"additional","affiliation":[{"name":"Helfgott Research Institute, National University of Natural Medicine, Portland, US"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5130","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12051"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2013.02.014"},{"key":"B3","first-page":"6S","volume":"45","author":"Browne AC","year":"1999","journal-title":"Ostomy Wound Manage"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-2176"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1177\/1534734607310299"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1097\/PHM.0b013e3182876a06"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/0741-5214(84)90069-7"},{"issue":"3","key":"B8","first-page":"335","volume":"115","author":"Conlon KC","year":"1994","journal-title":"Surgery"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/0741-5214(86)90388-5"},{"issue":"6","key":"B10","first-page":"796","volume":"9","author":"Kram HB","year":"1989","journal-title":"J Vasc Surg"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800710320"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(82)90604-3"},{"issue":"1","key":"B13","first-page":"43","volume":"36","author":"Fife CE","year":"2009","journal-title":"Undersea Hyperb Med"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.06.030"},{"issue":"3","key":"B15","first-page":"101","volume":"27","author":"Duran V","year":"2005","journal-title":"Int J Tissue React"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1023\/A:1020290010605"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2010.04.009"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1177\/1076029606290133"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-5214(98)70034-5"}],"container-title":["Journal of Wound Care"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/pdf\/10.12968\/jowc.2019.28.Sup2.S16","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,24]],"date-time":"2022-05-24T23:00:39Z","timestamp":1653433239000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/10.12968\/jowc.2019.28.Sup2.S16"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,1]]},"references-count":19,"journal-issue":{"issue":"Sup2","published-print":{"date-parts":[[2019,2,1]]}},"alternative-id":["10.12968\/jowc.2019.28.Sup2.S16"],"URL":"https:\/\/doi.org\/10.12968\/jowc.2019.28.sup2.s16","relation":{},"ISSN":["0969-0700","2052-2916"],"issn-type":[{"value":"0969-0700","type":"print"},{"value":"2052-2916","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,1]]}}}