{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:26:22Z","timestamp":1790774782983,"version":"4.1.0"},"reference-count":21,"publisher":"Mark Allen Group","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Wound Care"],"published-print":{"date-parts":[[2020,10,2]]},"abstract":"<jats:sec><jats:title>Objective:<\/jats:title><jats:p> There are currently no definitive guidelines regarding the management of split-thickness skin-graft (STSG) donor sites. The literature reports biological and non-biological dressings as the two main groups; however, there is no conclusive evidence regarding the ideal type. A systematic review and meta-analysis of existing clinical trials was performed to compare biological and non-biological dressings in managing STSG donor sites. <\/jats:p><\/jats:sec><jats:sec><jats:title>Method:<\/jats:title><jats:p> The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement standards was used to conduct this study. Electronic databases including MEDLINE, Embase, CINAHL and the Cochrane Central Register of Controlled Trials (CENTRAL) were searched by two authors (SR and BL). Data analysis was performed with RevMan 5.3. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> In total, 10 studies, consisting of eight randomised controlled trials and two observational assessments, were identified. Wound healing time was faster with biological dressings compared to non-biological dressings (mean difference -5.44 days; p&lt;0.05). A higher epithelialisation rate was also noted for biological dressings. There was no difference in the infection rate between the two study groups (odds ratio [OR] 0.39; 95% confidence interval [CI] 0.15\u20131.04) or wound exudation (OR 0.31; 95% CI 0.01\u20138.28). The pain level experienced during dressing changes in both groups was reported to be similar. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> The rate of epithelialisation and wound healing is greater for STSG donor sites when treated with biological dressings, but they offer no difference in terms of reducing pain, limiting infection or exudation. <\/jats:p><\/jats:sec>","DOI":"10.12968\/jowc.2020.29.10.604","type":"journal-article","created":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T18:52:00Z","timestamp":1602701520000},"page":"604-610","source":"Crossref","is-referenced-by-count":9,"title":["Biological versus non-biological dressings in the management of split-thickness skin-graft donor sites: a systematic review and meta-analysis"],"prefix":"10.12968","volume":"29","author":[{"given":"Shafiq","family":"Rahman","sequence":"first","affiliation":[{"name":"Hull Royal Infirmary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Langridge","sequence":"additional","affiliation":[{"name":"Royal Free Hospital, London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Al-Hadad","sequence":"additional","affiliation":[{"name":"University College London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rehman Ali","family":"Khan","sequence":"additional","affiliation":[{"name":"Cardiac and Thoracic Surgery, Royal Victoria Hospital, Belfast"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Hyder","family":"Junejo","sequence":"additional","affiliation":[{"name":"Genitourinary Medicine, Chelsea and Westminster Hospital, London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afshin","family":"Mosahebi","sequence":"additional","affiliation":[{"name":"Royal Free Hospital, London"},{"name":"Division of Surgery and Interventional Science, University College London"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5130","reference":[{"issue":"3","key":"B1","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s002669900112","volume":"21","author":"Ablaza VJ","year":"1997","journal-title":"Aesthetic Plast Surg"},{"key":"B2","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1186\/1745-6215-12-229","volume":"12","author":"Eskes AM","year":"2011","journal-title":"Trials"},{"issue":"12","key":"B3","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1016\/j.bjps.2008.07.036","volume":"62","author":"Geary PM","year":"2009","journal-title":"J Plast Reconstr Aesthet Surg"},{"issue":"1","key":"B4","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1097\/PRS.0b013e3181a8072f","volume":"124","author":"Voineskos SH","year":"2009","journal-title":"Plast Reconstr Surg"},{"issue":"10","key":"B5","doi-asserted-by":"crossref","first-page":"433","DOI":"10.12968\/jowc.2007.16.10.27912","volume":"16","author":"Terrill PJ","year":"2007","journal-title":"J Wound Care"},{"issue":"2","key":"B6","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1111\/j.1742-481X.2011.00867.x","volume":"9","author":"Higgins L","year":"2012","journal-title":"Int Wound J"},{"key":"B7","doi-asserted-by":"crossref","first-page":"572183","DOI":"10.1155\/2014\/572183","volume":"2014","author":"Loeffelbein DJ","year":"2014","journal-title":"Biomed Res Int"},{"issue":"1","key":"B8","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1097\/01.ASW.0000437786.92529.22","volume":"27","author":"Karlsson M","year":"2014","journal-title":"Adv Skin Wound Care"},{"key":"B9","first-page":"e45","volume":"13","author":"Davidson A","year":"2013","journal-title":"Eplasty"},{"key":"B10","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s12262-012-0789-9","volume":"77","author":"Subrahmanyam M.","year":"2015","journal-title":"Indian J Surg"},{"issue":"9","key":"B11","doi-asserted-by":"crossref","first-page":"e1928","DOI":"10.1097\/GOX.0000000000001928","volume":"6","author":"Serebrakian AT","year":"2018","journal-title":"Plast Reconstr Surg Glob Open"},{"issue":"7","key":"B12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1000097","volume":"6","author":"Moher D","year":"2009","journal-title":"PLoS Med"},{"key":"B14","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1007\/s13770-013-0004-5","volume":"10","author":"Singh R","year":"2013","journal-title":"Tissue Eng Regen Med"},{"issue":"1","key":"B15","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1755-1536-6-8","volume":"6","author":"Guerid S","year":"2013","journal-title":"Fibrogenesis Tissue Repair"},{"issue":"7","key":"B16","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1016\/j.burns.2015.03.009","volume":"41","author":"Zidan SM","year":"2015","journal-title":"Burns"},{"key":"B17","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s12262-013-0864-x","volume":"77","author":"Salehi SH","year":"2015","journal-title":"Indian J Surg"},{"issue":"3","key":"B18","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1097\/BCR.0b013e31829b3338","volume":"35","author":"Lairet KF","year":"2014","journal-title":"J Burn Care Res"},{"issue":"2","key":"B19","first-page":"168","volume":"29","author":"Misirlioglu A","year":"2003","journal-title":"Dermatol Surg"},{"issue":"6","key":"B20","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1111\/j.1600-0625.2012.01505.x","volume":"21","author":"Tang L","year":"2012","journal-title":"Exp Dermatol"},{"issue":"5","key":"B21","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/S1043-4666(03)00092-9","volume":"21","author":"Tonks AJ","year":"2003","journal-title":"Cytokine"},{"issue":"6","key":"B22","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/S1079-2104(98)90029-4","volume":"85","author":"Marx RE","year":"1998","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"}],"container-title":["Journal of Wound Care"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/pdf\/10.12968\/jowc.2020.29.10.604","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T18:56:06Z","timestamp":1602701766000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/10.12968\/jowc.2020.29.10.604"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,2]]},"references-count":21,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,10,2]]}},"alternative-id":["10.12968\/jowc.2020.29.10.604"],"URL":"https:\/\/doi.org\/10.12968\/jowc.2020.29.10.604","relation":{},"ISSN":["0969-0700","2052-2916"],"issn-type":[{"value":"0969-0700","type":"print"},{"value":"2052-2916","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,2]]}}}