{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T20:58:58Z","timestamp":1793134738127,"version":"4.5.0"},"reference-count":26,"publisher":"Mark Allen Group","issue":"Sup3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Wound Care"],"published-print":{"date-parts":[[2020,3,2]]},"abstract":"<jats:sec><jats:title>Objective:<\/jats:title><jats:p> Diabetic foot ulcers (DFU) are often hard-to-heal, despite standard care. With such a complicated healing process, any advanced wound care to aid healing is recommended. Chitosan\/collagen composite hydrogel materials have the potential to promote the regenerative process. In this study, the efficacy of a new collagen matrix dressing including chitosan\/collagen hydrogel was compared with a standard dressing of saline-moistened gauze for wound healing in patients with a hard-to-heal neuropathic DFU. <\/jats:p><\/jats:sec><jats:sec><jats:title>Method:<\/jats:title><jats:p> This is an open labelled, randomised clinical trial. After conventional therapy consisting of debridement, infection control and offloading, patients were randomly allocated to receive either a collagen matrix dressing (the study group, receiving Tebaderm manufacturer) or a saline-moistened gauze dressing (control group) for wound care. The reduction in DFU size and the number of patients with complete healing were measured throughout the treatment and in follow-up. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> A total of 61 patients with a neuropathic DFU were recruited. Average percentage reduction in DFU size at four weeks was greater in the study group compared with the control group (54.5% versus 38.8%, respectively). Rate of complete healing rate at 20-weeks' follow-up was significantly better in the study group than the control group (60% versus 35.5%, respectively). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> The collagen matrix dressing used in this study accelerated the healing process of patients with a hard-to-heal DFU. Further research may suggest the used of this dressing to shorten the length of time to achieve complete healing. <\/jats:p><\/jats:sec>","DOI":"10.12968\/jowc.2020.29.sup3.s13","type":"journal-article","created":{"date-parts":[[2020,3,11]],"date-time":"2020-03-11T18:07:07Z","timestamp":1583950027000},"page":"S13-S18","source":"Crossref","is-referenced-by-count":45,"title":["Application of a collagen matrix dressing on a neuropathic diabetic foot ulcer: a randomised control trial"],"prefix":"10.12968","volume":"29","author":[{"given":"Gholamreza Esmaeeli","family":"Djavid","sequence":"first","affiliation":[{"name":"1 Department of Photo Healing and Regeneration, Medical Laser Research Center, Yara Institute, Academic Center for Education, Culture and Research (ACECR), Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Mehdi","family":"Tabaie","sequence":"additional","affiliation":[{"name":"1 Department of Photo Healing and Regeneration, Medical Laser 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