{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T07:43:37Z","timestamp":1771919017307,"version":"3.50.1"},"reference-count":39,"publisher":"Mark Allen Group","issue":"Sup8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Wound Care"],"published-print":{"date-parts":[[2020,8,1]]},"abstract":"<jats:sec><jats:title>Objective:<\/jats:title><jats:p> The objective of this study was to assess the clinical effectiveness of surgically implanted cryopreserved human umbilical cord allograft in treating hard-to-heal wounds with and without osteomyelitis. <\/jats:p><\/jats:sec><jats:sec><jats:title>Method:<\/jats:title><jats:p> In this single-centre, retrospective investigation, wounds (average size 6.9\u00b110.1cm<jats:sup>2<\/jats:sup>) were included for analysis that had failed prior standard wound care for an average of 14.4\u00b18.0 weeks. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> After surgical implantation of cryopreserved umbilical cord between the deep tissue planes, 20 (95%) of the 21 wounds included in the study achieved complete closure in a median time of 7.8 weeks (range: 1\u201368) despite presence of residual osteomyelitis in 15 cases. A total of 12 wounds (57.1%) healed by 12 weeks, and 16 (76.2%) wounds healed by 24 weeks. A patient who presented with a limb-threatening calcaneal ulcer that was complicated by osteomyelitis at the time of treatment required subsequent amputation. No adverse events or complications related to cryopreserved umbilical cord were observed. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> The results suggest that surgical implantation of cryopreserved umbilical cord allograft may be a safe and effective treatment in improving healing of hard-to-heal wounds. 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