{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:01:36Z","timestamp":1787068896667,"version":"build-2736575974"},"reference-count":20,"publisher":"Mark Allen Group","issue":"Sup4a","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Wound Care"],"published-print":{"date-parts":[[2025,4,1]]},"abstract":"\n Objective:<\/jats:title>\n Keloid scars are extremely difficult to treat with current therapy options, such as surgical excision and steroids, and have high recurrence rates. Intralesional cryotherapy is a relatively new treatment modality that uses a double-lumen needle to freeze the scar from the core, outwards. Evidence from the literature supports its use, with recurrence rates reported between 0\u201323%. The aim of this study was to assess patient-reported outcomes of keloid scar treatment with intralesional cryotherapy.<\/jats:p>\n <\/jats:sec>\n \n Method:<\/jats:title>\n All patients who had undergone intralesional cryotherapy, with a minimum follow-up period of six weeks were asked to complete a questionnaire. Patients were asked to rate the appearance of their scar and severity of their symptoms on a Visual Analogue Scale. They also reported any side-effects, complications and whether they would recommend the treatment.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n A total of 52 patients were included between 2017 and 2019. All patients reported an improvement in scar appearance and 91% of patients reported an improvement in pain, with an average 3.75-point reduction in pain scores. All patients would recommend the treatment. Hypopigmentation was the most frequently reported side-effect and was most common in patients with Fitzpatrick skin types V and VI. A second treatment was required by three patients; all three had keloid scarring on the anterior chest and had previously had multiple courses of steroids.<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n The findings of our study appears to support the use of intralesional cryotherapy for the treatment of keloid scarring, with high patient satisfaction rates.<\/jats:p>\n <\/jats:sec>","DOI":"10.12968\/jowc.2021.0087","type":"journal-article","created":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T13:17:56Z","timestamp":1744636676000},"page":"xliv-xlviii","source":"Crossref","is-referenced-by-count":3,"title":["Intralesional cryotherapy for treatment of keloid scars: patient-reported outcomes"],"prefix":"10.12968","volume":"34","author":[{"given":"Kiran","family":"Dhaliwal","sequence":"first","affiliation":[{"name":"MBChB, BSc, MSc, MRCS, Department of Plastic and Reconstructive Surgery, Queen Elizabeth Hospital, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae","family":"Parks","sequence":"additional","affiliation":[{"name":"MRCS"},{"name":"Department of Plastic and Reconstructive Surgery, Queen Elizabeth Hospital, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Brewster","sequence":"additional","affiliation":[{"name":"FRCS (Plast), Department of Plastic and Reconstructive Surgery, Queen Elizabeth Hospital, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivram","family":"Singh","sequence":"additional","affiliation":[{"name":"FRCS (Plast), Department of Plastic and Reconstructive Surgery, Queen Elizabeth Hospital, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5130","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.5070\/D32M43548R"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2016.09.024"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1224797"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.137.11.1429"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12185"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199910000-00031"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200304040-00003"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8019.2012.01456.x"},{"key":"B9","volume-title":"Surgical treatments for cutaneous scar revision","author":"Zouboulis CC","year":"2000"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1177\/1534734608322813"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1097\/01.PRS.0000056868.42679.05"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2005.00084.x"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2010.03911.x"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000000911"},{"key":"B15","first-page":"205951311770216","volume":"3","author":"O'Boyle CP","year":"2017","journal-title":"Scars Burn Heal"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1097\/01.PRS.0000056868.42679.05"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2014.08.046"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2018.01.033"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1097\/01.PRS.0000122207.28773.56"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1007\/s00238-017-1360-5"}],"container-title":["Journal of Wound Care"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/pdf\/10.12968\/jowc.2021.0087","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T09:49:16Z","timestamp":1746179356000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/10.12968\/jowc.2021.0087"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,1]]},"references-count":20,"journal-issue":{"issue":"Sup4a","published-print":{"date-parts":[[2025,4,1]]}},"alternative-id":["10.12968\/jowc.2021.0087"],"URL":"https:\/\/doi.org\/10.12968\/jowc.2021.0087","relation":{},"ISSN":["0969-0700","2052-2916"],"issn-type":[{"value":"0969-0700","type":"print"},{"value":"2052-2916","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,1]]}}}