{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T18:41:48Z","timestamp":1764700908786,"version":"build-2065373602"},"reference-count":21,"publisher":"Mark Allen Group","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Wound Care"],"published-print":{"date-parts":[[2021,10,2]]},"abstract":"<jats:sec><jats:title>Objective:<\/jats:title><jats:p> This prospective case series aims to evaluate the clinical impact of a hypochlorous acid oxidising solution (AOS) in association with usual standard of care (SoC) on wound bed preparation (WBP) in patients with hard-to-heal ulcers of various aetiologies. The AOS (Nexodyn, APR Applied Pharma Research S.A., Switzerland) comprises three main features: highly pure and stabilised hypochlorous acid, acidic pH and high reduction\u2013oxidation potential. <\/jats:p><\/jats:sec><jats:sec><jats:title>Method:<\/jats:title><jats:p> Between February 2015 and February 2017, patients who met the inclusion criteria were treated with AOS and usual SoC. Data collection ran for 70 days: T0\u2013T70. A baseline assessment was undertaken at T0; parameters assessed at fortnightly visits included: WBP score, area and depth of ulcer, duration, pain, Bates\u2013Jensen score and infection status. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> A total of 60 patients took part in the study. By T70, 68.3% of wounds had healed or improved and a significant wound size reduction of 21% was observed (p&lt;0.001), despite a mean wound duration of 20.6 months. All wounds were free of local infection and cellulitis; 10% were colonised. WBP scores improved, while Bates\u2013Jensen and pain scores fell significantly over time. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> This evaluation suggests that AOS might represent a valuable therapeutic addition for an optimal WBP in the routine management of hard-to-heal ulcers of different aetiologies. <\/jats:p><\/jats:sec><jats:sec><jats:title>Declaration of interest:<\/jats:title><jats:p> ER worked as a consultant for APR Applied Pharma Research S.A. The authors have no other conflicts of interest. <\/jats:p><\/jats:sec>","DOI":"10.12968\/jowc.2021.30.10.830","type":"journal-article","created":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T17:45:36Z","timestamp":1634147136000},"page":"830-838","source":"Crossref","is-referenced-by-count":4,"title":["Wound bed preparation with hypochlorous acid oxidising solution and standard of care: a prospective case series"],"prefix":"10.12968","volume":"30","author":[{"given":"Elia","family":"Ricci","sequence":"first","affiliation":[{"name":"St Luca Clinic, Department of Surgery A, Pecetto Torinese (TO), Piedmont, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Pittarello","sequence":"additional","affiliation":[{"name":"St Luca Clinic, Department of Surgery A, Pecetto Torinese (TO), Piedmont, 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