{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T01:28:01Z","timestamp":1793064481663,"version":"4.5.0"},"reference-count":17,"publisher":"Mark Allen Group","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Wound Care"],"published-print":{"date-parts":[[2021,10,2]]},"abstract":"Objective:<\/jats:title> This study evaluated the impact of four weeks of treatment with Prontosan Wound Irrigation Solution and Prontosan Wound Gel (B. Braun Medical Inc., US) on adults with hard-to-heal leg wounds. Overall change (weeks 1\u20135) in the Global Quality of Life scale (GQOL), changes in body, psyche and everyday life (EDL) quality of life (QoL) subscores, and changes in wound appearance and size after treatment were assessed. <\/jats:p><\/jats:sec>Method:<\/jats:title> In this prospective, open-label, single-arm, five-centre study, non-hospitalised patients with no more than two wounds below the knee were recruited into the study; wounds were \u22655cm2<\/jats:sup> and \u226450cm2<\/jats:sup> and present for \u22654 weeks. The investigator or a designee applied the wound solution and gel to the wounds at clinic visits, and patients\/caregivers applied the wound solution and gel at home. Wound-QoL questionnaires were completed at the initial screening and at each week of treatment. Wound size and photographs were obtained at pre- and post-treatment during clinic visits. <\/jats:p><\/jats:sec>Results:<\/jats:title> A total of 43 patients were enrolled in the study. Mean GQOL scores decreased by 1.11 (46.1%). Body, psyche and EDL decreased by 1.17 (60.0%), 1.26 (41.8%) and 1.00 (42.2%), respectively. Wounds also showed improvement in odour, appearance and size. Adverse events were mild in intensity and transient in nature. <\/jats:p><\/jats:sec>Conclusion:<\/jats:title> This study demonstrated marked improvement in the QoL of patients with hard-to-heal leg wounds below the knee during four weeks of treatment with the wound solution and gel. Wounds also showed improvement in odour, appearance and size, and the treatment solution and gel were well tolerated. <\/jats:p><\/jats:sec>Declaration of interest:<\/jats:title> B. Braun Medical Inc. funded the research and preparation of this article. AK, DV, CRC and WC are employees of B. Braun Medical Inc. AO and RS declare no conflict of interest. <\/jats:p><\/jats:sec>","DOI":"10.12968\/jowc.2021.30.10.854","type":"journal-article","created":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T17:45:36Z","timestamp":1634147136000},"page":"854-865","source":"Crossref","is-referenced-by-count":12,"title":["Quality of life improvement in patients with hard-to-heal leg wounds treated with Prontosan wound irrigation solution and wound gel"],"prefix":"10.12968","volume":"30","author":[{"given":"Alisha","family":"Oropallo","sequence":"first","affiliation":[{"name":"Comprehensive Wound Healing Center, 1999 Marcus Ave Suite M6, North New Hyde Park, US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J","family":"Snyder","sequence":"additional","affiliation":[{"name":"Barry University, 11300 NE 2nd Ave, Miami Shores, Fl 33161, US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Karpf","sequence":"additional","affiliation":[{"name":"B. Braun Medical Inc., 824 12th Ave, Bethlehem, PA 18018, US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Valencia","sequence":"additional","affiliation":[{"name":"B. Braun Medical Inc., 824 12th Ave, Bethlehem, PA 18018, US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher R","family":"Curtin","sequence":"additional","affiliation":[{"name":"B. Braun Medical Inc., 824 12th Ave, Bethlehem, PA 18018, US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wes","family":"Cetnarowski","sequence":"additional","affiliation":[{"name":"B. Braun Medical Inc., 824 12th Ave, Bethlehem, PA 18018, US"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5130","reference":[{"issue":"3","key":"B1","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/dth.12051","volume":"26","author":"Richmond NA","year":"2013","journal-title":"Dermatol Ther"},{"key":"B3","unstructured":"Canadian Agency for Drugs and Technologies in Health. Optimal care of chronic, non-healing, lower extremity wounds: a review of clinical evidence and guidelines. Ottawa (ON), Canada, 2013"},{"issue":"9","key":"B4","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1089\/wound.2015.0635","volume":"4","author":"Frykberg RG","year":"2015","journal-title":"Adv Wound Care"},{"issue":"3","key":"B5","doi-asserted-by":"crossref","first-page":"160","DOI":"10.12968\/jowc.2016.25.3.160","volume":"25","author":"Bellingeri A","year":"2016","journal-title":"J Wound Care"},{"issue":"1","key":"B6","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.1524-475X.2007.00321.x","volume":"16","author":"James GA","year":"2008","journal-title":"Wound Repair Regen"},{"issue":"2","key":"B7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1742-481X.2012.01097.x","volume":"9","author":"Leaper DJ","year":"2012","journal-title":"Int Wound J"},{"key":"B8","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1159\/000318266","volume":"23","author":"Romanelli M","year":"2010","journal-title":"Skin Pharmacol Physiol"},{"issue":"6","key":"B10","first-page":"171","volume":"20","author":"Andriessen AE","year":"2008","journal-title":"Wounds"},{"key":"B11","volume-title":"Chronic wound care: the essentials; a clinical source book for healthcare professionals","volume":"1","author":"Price P","year":"2014","edition":"5"},{"issue":"4","key":"B18","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1111\/wrr.12193","volume":"22","author":"Blome C","year":"2014","journal-title":"Wound Repair Regen"},{"issue":"4","key":"B21","first-page":"247","volume":"31","author":"Valenzuela RA","year":"2008","journal-title":"Rev ROL Enf"},{"issue":"5","key":"B22","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.jpainsymman.2016.12.336","volume":"53","author":"Finlayson K","year":"2017","journal-title":"J Pain Symptom Manage"},{"issue":"4","key":"B23","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1097\/01.ASW.0000305430.01413.2e","volume":"21","author":"Woo KY","year":"2008","journal-title":"Adv Skin Wound Care"},{"issue":"4","key":"B24","first-page":"92","volume":"2","author":"Soon K","year":"2006","journal-title":"Wounds UK"},{"issue":"3","key":"B25","first-page":"20","volume":"15","author":"Wynn M","year":"2019","journal-title":"Wounds UK"},{"issue":"12","key":"B27","first-page":"318","volume":"21","author":"Fagervik-Morton H","year":"2009","journal-title":"Wounds"},{"issue":"2","key":"B28","doi-asserted-by":"crossref","first-page":"53","DOI":"10.12968\/jowc.2005.14.2.26732","volume":"14","author":"Hareendran A","year":"2005","journal-title":"J Wound Care"}],"container-title":["Journal of Wound Care"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/pdf\/10.12968\/jowc.2021.30.10.854","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T17:48:49Z","timestamp":1634147329000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/10.12968\/jowc.2021.30.10.854"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,2]]},"references-count":17,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10,2]]}},"alternative-id":["10.12968\/jowc.2021.30.10.854"],"URL":"https:\/\/doi.org\/10.12968\/jowc.2021.30.10.854","relation":{},"ISSN":["0969-0700","2052-2916"],"issn-type":[{"value":"0969-0700","type":"print"},{"value":"2052-2916","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,2]]}}}