{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T16:25:26Z","timestamp":1793291126948,"version":"4.5.0"},"reference-count":21,"publisher":"Mark Allen Group","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Wound Care"],"published-print":{"date-parts":[[2021,12,2]]},"abstract":"Background:<\/jats:title> The short-term application of negative pressure wound therapy with instillation and dwell time (NPWTi-d) enables the delivery of topical wound solutions, the solubilisation of debris and cleansing of the wound bed. The application of NPWTi-d may support the transition of the wound to a more manageable state and minimises the use of more invasive techniques. <\/jats:p><\/jats:sec>Method:<\/jats:title> In this case series, we describe the process of applying NPWTi-d early as part of a contaminated wound treatment plan. <\/jats:p><\/jats:sec>Results:<\/jats:title> The case series included 15 patients in the preoperative setting. Wound types included surgical dehiscence, hard-to-heal wounds, heel pressure ulcers, diabetic foot ulcers, a cat bite and an amputation left open. Normal saline or a 0.125% sodium hypochlorite solution were instilled and allowed to dwell for five minutes, followed by 15 minutes of continuous negative pressure at \u2013125mmHg. NPWTi-d was continued for 4\u201336 hours, or until the operating room became available. After NPWTi-d, we observed a decreased amount of devitalised tissue in the wound bed and reduced oedema and erythema in the periwound area. Patient white blood cells also significantly decreased in all cases after NPWTi-d (p<0.001). <\/jats:p><\/jats:sec>Conclusion:<\/jats:title> Short-term use of NPWTi-d may be a useful option for supporting the surgical treatment of contaminated lower extremity wounds. <\/jats:p><\/jats:sec>","DOI":"10.12968\/jowc.2021.30.12.994","type":"journal-article","created":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T15:42:11Z","timestamp":1639064531000},"page":"994-1000","source":"Crossref","is-referenced-by-count":6,"title":["Preoperative contaminated wound management using short-term negative pressure wound therapy with instillation"],"prefix":"10.12968","volume":"30","author":[{"given":"James","family":"Willmore","sequence":"first","affiliation":[{"name":"Advanced Foot and Ankle Center of San Diego, San Diego, CA, US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Wrotslavsky","sequence":"additional","affiliation":[{"name":"Advanced Foot and Ankle Center of San Diego, San Diego, CA, US"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5130","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.5999\/aps.2013.40.5.522"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.292.24.3006"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1089\/sur.2019.262"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1097\/BOT.0b013e3181e3dff1"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1177\/000313481207801010"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jemermed.2008.11.016"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-481X.2012.01014.x"},{"issue":"5","key":"B8","first-page":"775","volume":"143","author":"Wheeler CB","year":"1976","journal-title":"Surg Gynecol Obstet"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1097\/01.blo.0000144859.73074.45"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1969.40.11.671"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1097\/01.blo.0000182246.37454.b2"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-481X.2012.01073.x"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12452"},{"issue":"6","key":"B14","first-page":"167","volume":"20","author":"Angobaldo J","year":"2008","journal-title":"Wounds"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1086\/521660"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jccw.2014.02.001"},{"issue":"8","key":"B17","first-page":"240","volume":"29","author":"Yang C","year":"2017","journal-title":"Wounds"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1097\/PSN.0000000000000033"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000438060.46290.7a"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000001709"},{"issue":"12","key":"B21","first-page":"S2","volume":"27","author":"Kim PJ","year":"2015","journal-title":"Wounds"}],"container-title":["Journal of Wound Care"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/pdf\/10.12968\/jowc.2021.30.12.994","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T15:43:53Z","timestamp":1639064633000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/10.12968\/jowc.2021.30.12.994"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,2]]},"references-count":21,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,12,2]]}},"alternative-id":["10.12968\/jowc.2021.30.12.994"],"URL":"https:\/\/doi.org\/10.12968\/jowc.2021.30.12.994","relation":{},"ISSN":["0969-0700","2052-2916"],"issn-type":[{"value":"0969-0700","type":"print"},{"value":"2052-2916","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,2]]}}}