{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T02:30:04Z","timestamp":1700447404633},"reference-count":35,"publisher":"Mark Allen Group","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Wound Care"],"published-print":{"date-parts":[[2021,5,2]]},"abstract":"<jats:sec><jats:title>Objective:<\/jats:title><jats:p> The purpose of this research is to investigate the effect of low-frequency contact ultrasonic debridement therapy (LFCUD) in hard-to-heal wounds with suspected biofilm, and compare the effect with or without a surfactant antimicrobial on bacterial colony counts and wound healing rates. <\/jats:p><\/jats:sec><jats:sec><jats:title>Method:<\/jats:title><jats:p> A single-blinded randomised controlled trial (RCT) will investigate the combination of LFCUD and the antiseptic polyhexamethylene biguanide with a surfactant betaine (referred to in this paper as PHMB) as a topical solution post-treatment and in a sustained dressing, compared with use of LFCUD alone. Potential participants from a community wound clinic (n=50) will be invited to take part in the 12-week trial. Wound swabs and tissue samples will be analysed for bacterial type and quantity, before and after treatments, using traditional culture techniques and advanced molecular methods. Wound healing, pain, quality of life and biofilm (via a specifically designed tool) will also be measured. <\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion:<\/jats:title><jats:p> Bacteria have the potential to cause a hard-to-heal wound, particularly when antibiotics are too frequently and unnecessarily prescribed, resulting in antibiotic-resistant microorganisms. Appropriate care is vital when caring for hard-to-heal wounds to avoid these scenarios. With no simple laboratory method available to identify or treat wound biofilm, clinicians rely on their expertise in wound management. This study aims to provide in vivo evidence on the effectiveness of PHMB, to prevent the reformation of biofilm when applied after LFCUD. The aim is to provide evidence-based and more cost-effective wound care. <\/jats:p><\/jats:sec>","DOI":"10.12968\/jowc.2021.30.5.372","type":"journal-article","created":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T17:25:58Z","timestamp":1620840358000},"page":"372-379","source":"Crossref","is-referenced-by-count":3,"title":["Use of low-frequency contact ultrasonic debridement with and without polyhexamethylene biguanide in hard-to-heal leg ulcers: an RCT protocol"],"prefix":"10.12968","volume":"30","author":[{"given":"Alison","family":"Vallejo","sequence":"first","affiliation":[{"name":"Wound Solutions Clinic, School of Nursing, Midwifery and Paramedicine, The University of the Sunshine Coast, Locked Bag 4, Maroochydore, QLD 4558, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianne","family":"Wallis","sequence":"additional","affiliation":[{"name":"School of Nursing, Midwifery and Paramedicine, The University of the Sunshine Coast, Locked Bag 4, Maroochydore, QLD 4558, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"McMillan","sequence":"additional","affiliation":[{"name":"INFLAME Biomedical Research Cluster, School of Health and Sports Sciences, The University of the Sunshine Coast, Maroochydore, QLD 4558, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleanor","family":"Horton","sequence":"additional","affiliation":[{"name":"School of Nursing, Midwifery and Paramedicine, The University of the Sunshine Coast, Locked Bag 4, Maroochydore, QLD 4558, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5130","reference":[{"issue":"5","key":"B2","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1111\/wrr.12590","volume":"25","author":"Schultz G","year":"2017","journal-title":"Wound Repair Regen"},{"issue":"3","key":"B3","first-page":"24","volume":"5","author":"Wolcott R.","year":"2014","journal-title":"Wounds Middle East"},{"key":"B6","volume-title":"Microbial biofilms importance and applications","author":"Metcalf D","year":"2016"},{"key":"B7","volume-title":"Essential microbiology for wound care","author":"Cooper R.","year":"2016"},{"issue":"8","key":"B8","doi-asserted-by":"crossref","first-page":"18","DOI":"10.25270\/owm.2018.8.1828","volume":"64","author":"Hill R","year":"2018","journal-title":"Ostomy Wound Manage"},{"key":"B10","volume-title":"Biotechnology Volume XI: Fundamentals in biotechnology","author":"Alhede M","year":"2009"},{"key":"B11","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.12968\/jowc.2013.22.Sup1.S1","volume":"22","author":"Strohal R","year":"2013","journal-title":"J Wound Care"},{"issue":"12","key":"B12","first-page":"46","volume":"29","author":"Hadi SA","year":"2016","journal-title":"Podiatry Today"},{"issue":"9","key":"B13","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1097\/00129334-200511000-00012","volume":"18","author":"Stanisic MM","year":"2005","journal-title":"Adv Skin Wound Care"},{"key":"B14","volume-title":"Wound healing: evidence-based management","author":"Kloth LC","year":"2010"},{"issue":"2","key":"B15","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.ejvs.2006.09.027","volume":"33","author":"Tan J","year":"2007","journal-title":"Eur J Vasc Endovasc Surg"},{"issue":"3","key":"B16","first-page":"122","volume":"26","author":"Carville K","year":"2018","journal-title":"Wound Practice and Research"},{"key":"B17","first-page":"4","volume":"26","author":"Vallejo A","year":"2018","journal-title":"Wound Practice & Research"},{"issue":"12","key":"B19","doi-asserted-by":"crossref","first-page":"582","DOI":"10.12968\/jowc.2015.24.12.582","volume":"24","author":"\u00c7eviker K","year":"2015","journal-title":"J Wound Care"},{"issue":"2","key":"B20","doi-asserted-by":"crossref","first-page":"64","DOI":"10.12968\/jowc.2015.24.2.64","volume":"24","author":"Crone S","year":"2015","journal-title":"J Wound Care"},{"key":"B22","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1159\/000318264","volume":"23","author":"H\u00fcbner NO","year":"2010","journal-title":"Skin Pharmacol Physiol"},{"key":"B23","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1093\/med\/9780198716006.003.0007","volume-title":"Essential microbiology for wound care","author":"Roberts C.","year":"2016"},{"key":"B25","volume-title":"Wound management for the advanced practitioner","author":"Swanson T.","year":"2014"},{"key":"B26","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/iwj.12175","volume":"10","author":"Daeschlein G.","year":"2013","journal-title":"Int Wound J"},{"issue":"11","key":"B28","doi-asserted-by":"crossref","first-page":"S24","DOI":"10.12968\/bjon.2010.19.Sup4.48423","volume":"19","author":"Cutting KF.","year":"2010","journal-title":"Br J Nurs"},{"key":"B29","doi-asserted-by":"crossref","first-page":"S16","DOI":"10.12968\/bjon.2012.21.Sup12.S16","volume":"21","author":"Butcher M.","year":"2012","journal-title":"Br J Nurs"},{"issue":"1","key":"B31","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/wrr.12394","volume":"24","author":"Marston W","year":"2016","journal-title":"Wound Repair Regen"},{"issue":"4","key":"B33","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1002\/rnj.258","volume":"41","author":"Zeigler M","year":"2016","journal-title":"Rehabil Nurs"},{"issue":"3","key":"B34","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1590\/S0104-11692007000300005","volume":"15","author":"Santos VL","year":"2007","journal-title":"Rev Lat Am Enfermagem"},{"issue":"2","key":"B35","first-page":"26","volume":"56","author":"Hon J","year":"2010","journal-title":"Ostomy Wound Manage"},{"issue":"3","key":"B37","doi-asserted-by":"crossref","first-page":"109","DOI":"10.12968\/jowc.2012.21.3.109","volume":"21","author":"Hurlow J","year":"2012","journal-title":"J Wound Care"},{"issue":"11","key":"B38","doi-asserted-by":"crossref","first-page":"534","DOI":"10.12968\/jowc.2011.20.11.534","volume":"20","author":"Lenselink E","year":"2011","journal-title":"J Wound Care"},{"issue":"6","key":"B39","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/j.jpainsymman.2010.08.016","volume":"41","author":"Hjermstad MJ","year":"2011","journal-title":"J Pain Symptom Manage"},{"issue":"7","key":"B40","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1111\/j.1526-4637.2007.00316.x","volume":"8","author":"Herr K","year":"2007","journal-title":"Pain Med"},{"issue":"4","key":"B41","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1111\/wrr.12193","volume":"22","author":"Blome C","year":"2014","journal-title":"Wound Repair Regen"},{"issue":"2","key":"B43","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1097\/00005373-197602000-00002","volume":"16","author":"Levine NS","year":"1976","journal-title":"J Trauma Inj Infect Crit Care"},{"issue":"1","key":"B44","doi-asserted-by":"crossref","first-page":"12","DOI":"10.12968\/jowc.2012.21.1.12","volume":"21","author":"Eberlein T","year":"2012","journal-title":"J Wound Care"},{"issue":"4","key":"B45","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.3758\/BRM.41.4.1149","volume":"41","author":"Faul F","year":"2009","journal-title":"Behav Res Methods"},{"issue":"11","key":"B46","doi-asserted-by":"crossref","first-page":"726","DOI":"10.7326\/0003-4819-152-11-201006010-00232","volume":"152","author":"Shulz K","year":"2010","journal-title":"Ann Intern Med"},{"key":"B47","doi-asserted-by":"crossref","DOI":"10.1093\/med\/9780198716006.001.0001","volume-title":"Essential microbiology for wound care","author":"Edwards-Jones V.","year":"2016"}],"container-title":["Journal of Wound Care"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/pdf\/10.12968\/jowc.2021.30.5.372","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T17:31:39Z","timestamp":1620840699000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/10.12968\/jowc.2021.30.5.372"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,2]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5,2]]}},"alternative-id":["10.12968\/jowc.2021.30.5.372"],"URL":"https:\/\/doi.org\/10.12968\/jowc.2021.30.5.372","relation":{},"ISSN":["0969-0700","2052-2916"],"issn-type":[{"value":"0969-0700","type":"print"},{"value":"2052-2916","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,2]]}}}