{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T23:03:24Z","timestamp":1773270204846,"version":"3.50.1"},"reference-count":20,"publisher":"Mark Allen Group","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Wound Care"],"published-print":{"date-parts":[[2021,5,2]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p>Dermatitis of surrounding skin may complicate hard-to-heal leg ulcers, delaying wound healing. The coexistence of hard-to-heal leg ulcers and irritant or allergic contact dermatitis may create difficulties for both diagnostic and therapeutic management.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective:<\/jats:title><jats:p>The aim of our study was to evaluate the incidence of dermatitis occurring in the surrounding skin in a population affected by hard-to-heal leg ulcers during treatment, and to differentiate between allergic contact dermatitis (ACD) and irritant contact dermatitis (ICD) with the use of a patch test. Furthermore, we investigated which medications were most probably related to these conditions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method:<\/jats:title><jats:p>We conducted an observational study from 21 February to 21 July 2017, enlisting all patients affected by hard-to-heal leg ulcers who attended the Wound Care Service of the Dermatologic Department of ASST, Spedali Civili, Brescia, Italy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>We enrolled 95 patients; 81 patients did not develop dermatitis, while 14 patients developed dermatitis of the surrounding skin. These patients underwent a patch test which gave a positive result in seven patients, permitting the diagnosis of ACD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p>Our study confirmed the incidence of dermatitis of the surrounding skin reported in the literature but reassessed the incidence of ACD as opposed to ICD.<\/jats:p><\/jats:sec>","DOI":"10.12968\/jowc.2021.30.5.394","type":"journal-article","created":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T17:25:58Z","timestamp":1620840358000},"page":"394-398","source":"Crossref","is-referenced-by-count":4,"title":["Allergic contact versus irritant contact dermatitis in patients with hard-to-heal leg ulcer: clinical and diagnostic approach"],"prefix":"10.12968","volume":"30","author":[{"given":"Paola","family":"Monari","sequence":"first","affiliation":[{"name":"Dermatology Department, University of Brescia, ASST Spedali Civili di Brescia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Fusano","sequence":"additional","affiliation":[{"name":"Dermatology Department, University of Brescia, ASST Spedali Civili di Brescia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruggero","family":"Moro","sequence":"additional","affiliation":[{"name":"Dermatology Department, University of Brescia, ASST Spedali Civili di Brescia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilaria","family":"Baiguini","sequence":"additional","affiliation":[{"name":"Dermatology Department, University of Brescia, ASST Spedali Civili di Brescia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PierGiacomo","family":"Calzavara-Pinton","sequence":"additional","affiliation":[{"name":"Dermatology Department, University of Brescia, ASST Spedali Civili di Brescia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annalisa","family":"Vascellaro","sequence":"additional","affiliation":[{"name":"Dermatology Department, University of Brescia, ASST Spedali Civili di Brescia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulio","family":"Gualdi","sequence":"additional","affiliation":[{"name":"Dermatology Department, University of Chieti and Pescara, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5130","reference":[{"issue":"11","key":"B1","first-page":"294","volume":"19","author":"Romanelli M","year":"2007","journal-title":"Wounds"},{"issue":"3","key":"B2","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/cod.12763","volume":"77","author":"Erfurt-Berge C","year":"2017","journal-title":"Contact Dermatitis"},{"issue":"4","key":"B3","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1111\/iwj.12905","volume":"15","author":"Rai R","year":"2018","journal-title":"Int 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