{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,26]],"date-time":"2024-08-26T15:09:26Z","timestamp":1724684966349},"reference-count":19,"publisher":"Mark Allen Group","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Wound Care"],"published-print":{"date-parts":[[2021,7,2]]},"abstract":"<jats:sec><jats:title>Objective:<\/jats:title><jats:p>To estimate whether thigh-administered intermittent pneumatic compression (IPC) could potentially afford the UK's National Health Service (NHS) a cost-effective intervention for the management of hard-to-heal venous leg ulcers (VLUs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method:<\/jats:title><jats:p>A Markov model was constructed depicting the management of hard-to-heal VLUs with IPC plus standard care or standard care alone over a period of 24 weeks. The model estimated the cost-effectiveness of the two interventions in terms of the incremental cost per quality-adjusted life year (QALY) gained at 2019\/20 prices.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Treatment of hard-to-heal VLUs with IPC plus standard care instead of standard care alone is expected to increase the probability of healing by 58% (from 0.24 to 0.38) at 24 weeks and increase health-related quality of life over 24 weeks from 0.32 to 0.34 QALYs per patient. Additionally, the cost of treating with IPC plus standard care (\u00a33,020 per patient) instead of standard care alone (\u00a33,037 per patient) has the potential to be cost-neutral if use of this device is stopped after 6 weeks in non-improving wounds. Sensitivity analysis showed that the relative cost-effectiveness of IPC plus standard care remains &lt;\u00a320,000 per QALY with plausible variations in costs and effectiveness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p>Within the limitations of this study, the addition of IPC to standard care potentially affords a cost-effective treatment to the NHS for managing hard-to-heal VLUs. However, a controlled study is required to validate the outcomes of this analysis.<\/jats:p><\/jats:sec>","DOI":"10.12968\/jowc.2021.30.7.544","type":"journal-article","created":{"date-parts":[[2021,7,14]],"date-time":"2021-07-14T08:08:52Z","timestamp":1626250132000},"page":"544-552","source":"Crossref","is-referenced-by-count":7,"title":["Cost-effectiveness of using intermittent pneumatic compression to manage hard-to-heal venous leg ulcers in the UK"],"prefix":"10.12968","volume":"30","author":[{"given":"Julian F","family":"Guest","sequence":"first","affiliation":[{"name":"Catalyst Consultants, Poole, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Staines","sequence":"additional","affiliation":[{"name":"Accelerate CIC, St Joseph's Hospice, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina","family":"Murphy","sequence":"additional","affiliation":[{"name":"NELFT Community Services, NELFT NHS Foundation Trust, London, 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