{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T14:25:42Z","timestamp":1773930342090,"version":"3.50.1"},"reference-count":52,"publisher":"Mark Allen Group","issue":"Sup4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Wound Care"],"published-print":{"date-parts":[[2021,4,1]]},"abstract":"<jats:sec><jats:title>Objective:<\/jats:title><jats:p>Management of chronic wounds remains one of the major challenges for health professionals and patients. An evidence-based decision is important to ensure that patients are receiving the best treatment proven to reduce healing time and improve outcomes, including economic benefits and patients' health-related quality of life (HRQoL). Due to recent restrictions because of the COVID-19 pandemic, including closure of wound care centres within hospitals and a drop in patient volume, chronic wound management needs simple-to-use dressings which are still effective and evidence-based solutions. This systematic review was conducted to identify the clinical evidence available on a sucrose octasulfate dressing (TLC-NOSF, UrgoStart dressing range, Laboratoires Urgo, France) to explore its efficacy in the management of chronic wounds, particularly lower limb ulcers, diabetic foot ulcers and pressure ulcers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method:<\/jats:title><jats:p>A literature search of PubMed, Cochrane Library and Google Scholar was conducted based on the PICO model (patient\/population, intervention, comparison and outcomes) to retrieve publications of different levels of evidence in order to evaluate outcomes of the use of TLC-NOSF dressings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>A total of 21 publications of different levels, ranging from double-blind randomised control trials to case reports, involving over 12,000 patients, were identified through PubMed, with a further eight publications through Google Scholar and two publications through Cochrane Library. A total of seven results were omitted due to the lack of relevance or repetition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p>All the evidence provided suggest that these dressings provide clinicians with an evidence-based option for the management of chronic wounds; that the TLC-NOSF dressings are beneficial in promoting the healing process, reducing healing times, enhancing patients' HRQoL, and in allowing a more cost-effective procedure.<\/jats:p><\/jats:sec>","DOI":"10.12968\/jowc.2021.30.sup4.s42","type":"journal-article","created":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T17:32:52Z","timestamp":1618507972000},"page":"S42-S52","source":"Crossref","is-referenced-by-count":14,"title":["Benefits of sucrose octasulfate (TLC-NOSF) dressings in the treatment of chronic wounds: a systematic review"],"prefix":"10.12968","volume":"30","author":[{"given":"Harikrishna","family":"Nair","sequence":"first","affiliation":[{"name":"Head and Consultant, Wound Care Unit, Department of Internal Medicine, Kuala Lumpur Hospital, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Venkateshwaran","sequence":"additional","affiliation":[{"name":"Consultant Plastic and Cosmetic Surgery, Jupiter Hospital, Mumbai, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selva","family":"Seetharaman S","sequence":"additional","affiliation":[{"name":"Consultant and Head of Department of Plastic and Reconstructive Surgery, Gleneagles Global Hospital, Chennai, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wuquan","family":"Deng","sequence":"additional","affiliation":[{"name":"Head of Endocrinology Department. 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