{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T10:59:17Z","timestamp":1792753157171,"version":"4.5.0"},"reference-count":44,"publisher":"Mark Allen Group","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Wound Care"],"published-print":{"date-parts":[[2022,1,2]]},"abstract":"<jats:sec><jats:title>Objective:<\/jats:title><jats:p>Diabetic foot ulcers (DFUs) are one of the most serious diabetic consequences, leading to amputations. Various therapies have been used to treat DFUs; however, a combination of negative pressure suction, artificial skin and autogenous skin implantation have never been investigated. This study aimed to evaluate the effectiveness of a novel three-step therapy protocol using negative pressure wound therapy (NPWT), artificial skin and autogenous skin implantation in patients with DFUs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method:<\/jats:title><jats:p>At a single tertiary university hospital between 2015 and 2018, the three-step therapy protocol was applied to patients with DFUs and its safety and efficacy was investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>A total of 21 patients took part in the study. The majority of the patients were female (62%), with a mean age of 65 years and a mean body mass index of 21kg\/m<jats:sup>2<\/jats:sup>. A third (n=7) of operative sites experienced minor complications, with two requiring re-operation. At a median follow up of 24 months, the average time of complete wound healing was 46 days, and the wound healing rate was 71%. The first-stage wound healing rate was 90%. All patients had achieved remission without any further recurrence of disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p>This comprehensive surgical technique for managing DFUs achieved a high local cure rate, minimal functional morbidity, and acceptable wound complication rates. The three-step therapy protocol has the potential to promote the healing process of DFUs, which is expected to serve as a new method for the treatment and cure of DFUs.<\/jats:p><\/jats:sec>","DOI":"10.12968\/jowc.2022.31.1.40","type":"journal-article","created":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T20:55:18Z","timestamp":1643144118000},"page":"40-46","source":"Crossref","is-referenced-by-count":6,"title":["Negative pressure wound therapy, artificial skin and autogenous skin implantation in diabetic foot ulcers"],"prefix":"10.12968","volume":"31","author":[{"given":"Hu","family":"Chia-Jui","sequence":"first","affiliation":[{"name":"Department of Orthopedics, Xiamen ChangGung Hospital, Xiamen City, Fujian Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lai","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Xiamen ChangGung Hospital, Xiamen City, Fujian Province, 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