{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T18:13:42Z","timestamp":1787595222798,"version":"build-2736575974"},"reference-count":74,"publisher":"Mark Allen Group","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Wound Care"],"published-print":{"date-parts":[[2022,10,2]]},"abstract":"<jats:sec><jats:title>Objective:<\/jats:title><jats:p> A new compound, Debrichem (DEBx Medical BV, the Netherlands), a topical desiccation agent (TDA), is an active gel that contains an acidic species with a potent hygroscopic action. When in contact with microorganisms and necrosis, rapid desiccation and carbonisation of the proteins in these microorganisms, as well as of the extracellular matrix of biofilms and necrosis, occurs. The resulting \u2018precipitate\u2019 rapidly dislodges from the wound bed, resulting in a clean wound which granulates, which is a prerequisite for healing by secondary intention. <\/jats:p><\/jats:sec><jats:sec><jats:title>Method:<\/jats:title><jats:p> In a retrospective study, a series of mostly large and hard-to-heal lesions of different aetiologies were treated with a one-time application of the TDA, followed by weekly dressing changes. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> Of the total of 54 lesions included in this case series, 22 were diagnosed as venous leg ulcers (VLUs), 20 as diabetic foot ulcers (DFUs), nine as post-traumatic, hard-to-heal lesions, two as vascular ulcers and one as an ischaemic ulcer. All of the VLUs, 75% of the DFUs and all of the other lesions reached complete granulation. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> The use of a TDA may contribute to the consistent, fast and easy removal of both biofilms and necrosis, and hence to wound healing. <\/jats:p><\/jats:sec>","DOI":"10.12968\/jowc.2022.31.10.816","type":"journal-article","created":{"date-parts":[[2022,10,14]],"date-time":"2022-10-14T22:59:34Z","timestamp":1665788374000},"page":"816-822","source":"Crossref","is-referenced-by-count":10,"title":["A desiccation compound as a biofilm- and necrosis-removing agent: a case series"],"prefix":"10.12968","volume":"31","author":[{"given":"Alberto","family":"Cogo","sequence":"first","affiliation":[{"name":"Villa Berica Hospital, Vicenza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A Carlo","family":"Bignozzi","sequence":"additional","affiliation":[{"name":"Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Ferrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel HE","family":"Hermans","sequence":"additional","affiliation":[{"name":"Hermans Medical Consulting, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bert J","family":"Quint","sequence":"additional","affiliation":[{"name":"DEBx, Rotterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes Petrus","family":"Snels","sequence":"additional","affiliation":[{"name":"DEBx, Rotterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Schultz","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Director, Institute for Wound Research. University of Florida, Gainesville, FL, US"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5130","reference":[{"issue":"2","key":"B1","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s40266-016-0343-8","volume":"33","author":"Pugliese DJ.","year":"2016","journal-title":"Drugs Aging"},{"key":"B2","first-page":"5","volume":"68","author":"Situm M","year":"2014","journal-title":"Acta Med Croatica"},{"issue":"3","key":"B3","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1080\/14737167.2019.1567337","volume":"19","author":"Geraghty T","year":"2019","journal-title":"Expert Rev Pharmacoecon Outcomes Res"},{"issue":"5","key":"B4","doi-asserted-by":"crossref","first-page":"347","DOI":"10.3111\/13696998.2014.903258","volume":"17","author":"Rice JB","year":"2014","journal-title":"J Med Econ"},{"issue":"6","key":"B5","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/S1067-2516(96)80134-7","volume":"35","author":"Armstrong DG","year":"1996","journal-title":"J Foot Ankle Surg"},{"issue":"9","key":"B6","first-page":"S19","volume":"29","author":"Gupta S","year":"2017","journal-title":"Wounds"},{"issue":"9","key":"B7","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s10354-016-0487-5","volume":"166","author":"B\u00f6hler K.","year":"2016","journal-title":"Wien Med Wochenschr"},{"key":"B8","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1177\/0268355516632998","volume":"31","author":"Raffetto JD.","year":"2016","journal-title":"Phlebology: The Journal of Venous Disease"},{"issue":"2","key":"B9","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.suc.2017.11.002","volume":"98","author":"Raffetto JD.","year":"2018","journal-title":"Surg Clin North Am"},{"issue":"1","key":"B10","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1177\/1534734612474303","volume":"12","author":"Tellechea A","year":"2013","journal-title":"Int J Low Extrem Wounds"},{"issue":"12","key":"B11","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.3390\/ijms17122085","volume":"17","author":"Zhao R","year":"2016","journal-title":"Int J Mol Sci"},{"issue":"1","key":"B12","doi-asserted-by":"crossref","first-page":"117","DOI":"10.2337\/dc08-0763","volume":"32","author":"Liu Y","year":"2009","journal-title":"Diabetes Care"},{"issue":"2","key":"B13","first-page":"149","volume":"3","author":"Mannello F","year":"2011","journal-title":"Am J Transl Res"},{"key":"B14","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1177\/00033197050560i102","volume":"56","author":"Pascarella L","year":"2005","journal-title":"Angiology"},{"key":"B15","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.12968\/bjcn.2015.20.Sup3.S6","volume":"20","author":"Rajpaul K.","year":"2015","journal-title":"Br J Community Nurs"},{"issue":"6","key":"B16","doi-asserted-by":"crossref","first-page":"305","DOI":"10.12968\/jowc.2016.25.6.305","volume":"25","author":"Bianchi T","year":"2016","journal-title":"J Wound Care"},{"issue":"9","key":"B17","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.biopha.2007.08.012","volume":"61","author":"Loo WT","year":"2007","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"B18","doi-asserted-by":"crossref","first-page":"20","DOI":"10.12968\/jowc.2017.26.1.20","volume":"26","author":"Malone M","year":"2017","journal-title":"J Wound Care"},{"issue":"5","key":"B19","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1111\/j.1524-475X.2012.00836.x","volume":"20","author":"Percival SL","year":"2012","journal-title":"Wound Repair Regen"},{"issue":"2","key":"B20","doi-asserted-by":"crossref","first-page":"45","DOI":"10.12968\/jowc.2010.19.2.46966","volume":"19","author":"Wolcott RD","year":"2010","journal-title":"J Wound Care"},{"issue":"8","key":"B21","doi-asserted-by":"crossref","first-page":"333","DOI":"10.12968\/jowc.2008.17.8.30796","volume":"17","author":"Wolcott RD","year":"2008","journal-title":"J Wound Care"},{"issue":"6","key":"B22","first-page":"S1","volume":"29","author":"Snyder RJ","year":"2017","journal-title":"Wounds"},{"issue":"7","key":"B23","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1089\/wound.2014.0574","volume":"4","author":"Percival SL","year":"2015","journal-title":"Adv Wound Care"},{"issue":"2","key":"B24","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1097\/00129334-200403000-00012","volume":"17","author":"Ayello EA","year":"2004","journal-title":"Adv Skin Wound Care"},{"issue":"4","key":"B25","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1097\/00152193-200404000-00040","volume":"34","author":"Ayello EA","year":"2004","journal-title":"Nursing"},{"issue":"9","key":"B26","first-page":"CD008599","author":"Gethin G","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"B27","unstructured":"Manna B, Nahirniak P, Morrison CA. Wound debridement. StatPearls, Treasure Island (FL), 2019"},{"key":"B28","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1177\/0268355513477015","volume":"28","author":"Mosti G.","year":"2013","journal-title":"Phlebology: The Journal of Venous Disease"},{"key":"B29","doi-asserted-by":"crossref","first-page":"S14","DOI":"10.12968\/bjcn.2013.18.Sup12.S14","volume":"18","author":"Turns M.","year":"2013","journal-title":"Br J Community Nurs"},{"issue":"6","key":"B30","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1111\/j.1524-475X.2006.00175.x","volume":"14","author":"Whitney J","year":"2006","journal-title":"Wound Repair Regen"},{"issue":"11","key":"B31","doi-asserted-by":"crossref","first-page":"498","DOI":"10.12968\/jowc.2015.24.11.498","volume":"24","author":"Percival SL","year":"2015","journal-title":"J Wound Care"},{"issue":"5","key":"B32","first-page":"107","volume":"24","author":"Riley WB","year":"1981","journal-title":"Am Fam Physician"},{"issue":"3","key":"B33","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1053\/j.semvascsurg.2015.12.003","volume":"28","author":"Cooper MA","year":"2015","journal-title":"Semin Vasc Surg"},{"issue":"3","key":"B34","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/iwj.12045","volume":"10","author":"Madhok BM","year":"2013","journal-title":"Int Wound J"},{"issue":"1","key":"B35","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/wrr.12394","volume":"24","author":"Marston W","year":"2016","journal-title":"Wound Repair Regen"},{"issue":"6","key":"B36","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1111\/iwj.12760","volume":"14","author":"Patry J","year":"2017","journal-title":"Int Wound J"},{"issue":"12","key":"B37","first-page":"367","volume":"29","author":"Raposio E","year":"2017","journal-title":"Wounds"},{"issue":"11","key":"B38","first-page":"32","volume":"52","author":"Bolton L","year":"2006","journal-title":"Ostomy Wound Manage"},{"issue":"4","key":"B39","first-page":"409","volume":"88","author":"Mancini S","year":"2018","journal-title":"Acta Biomed"},{"issue":"1","key":"B40","first-page":"24","volume":"10","author":"Gordon KA","year":"2012","journal-title":"Skinmed"},{"issue":"1","key":"B41","doi-asserted-by":"crossref","first-page":"55","DOI":"10.11607\/prd.2557","volume":"36","author":"Pini-Prato G","year":"2016","journal-title":"Int J Periodontics Restorative Dent"},{"key":"B42","author":"Bignozzi AC","year":"2020","journal-title":"Patent Cooperation Treaty Nr PCT\/IB2019\/051146"},{"issue":"3","key":"B43","first-page":"E14","volume":"31","author":"Metcalf D","year":"2019","journal-title":"Wounds"},{"issue":"3","key":"B44","doi-asserted-by":"crossref","first-page":"137","DOI":"10.12968\/jowc.2014.23.3.137","volume":"23","author":"Metcalf DG","year":"2014","journal-title":"J Wound Care"},{"issue":"6","key":"B46","doi-asserted-by":"crossref","first-page":"600","DOI":"10.4085\/1062-6050-43.6.600","volume":"43","author":"Beam JW.","year":"2008","journal-title":"J Athl Train"},{"key":"B47","first-page":"37","volume":"3","author":"Bruno W","year":"1994","journal-title":"Surg Technol Int"},{"issue":"6","key":"B48","doi-asserted-by":"crossref","first-page":"227","DOI":"10.12968\/jowc.2004.13.6.26625","volume":"13","author":"Bryan J.","year":"2004","journal-title":"J Wound Care"},{"issue":"3","key":"B49","first-page":"174","volume":"8","author":"Chang H","year":"1996","journal-title":"Dermatol Nurs"},{"issue":"2","key":"B50","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1177\/107110078100200202","volume":"2","author":"Wagner FW","year":"1981","journal-title":"Foot Ankle"},{"issue":"6","key":"B51","first-page":"277","volume":"11","author":"Anstead GM.","year":"1998","journal-title":"Adv Wound Care"},{"issue":"1","key":"B52","first-page":"22","volume":"19","author":"Goforth P","year":"1980","journal-title":"J Foot Surg"},{"issue":"6","key":"B53","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1055\/s-2007-965231","volume":"39","author":"Damert HG","year":"2007","journal-title":"Handchir Mikrochir Plast Chir"},{"issue":"5","key":"B54","first-page":"196","volume":"13","author":"Karrer K","year":"1958","journal-title":"Klin Med Osterr Z Wiss Prakt Med"},{"key":"B55","first-page":"301","volume":"52","author":"Tala P","year":"1963","journal-title":"Ann Chir Gynaecol Fenn"},{"issue":"17","key":"B56","doi-asserted-by":"crossref","first-page":"9471","DOI":"10.3390\/ijms22179471","volume":"22","author":"Schwarzer S","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"5","key":"B57","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1097\/00005373-198805000-00014","volume":"28","author":"Mozingo DW","year":"1988","journal-title":"J Trauma Inj Infect Crit Care"},{"issue":"8","key":"B58","first-page":"512","volume":"122","author":"Saada V","year":"1995","journal-title":"Ann Dermatol Venereol"},{"key":"B59","unstructured":"Schwerin DL, Hatcher JD. Hydrofluoric acid burns. StatPearls, Treasure Island (FL), 2022"},{"issue":"6","key":"B60","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1111\/j.1524-475X.2008.00427.x","volume":"16","author":"Franz MG","year":"2008","journal-title":"Wound Repair Regen"},{"issue":"11","key":"B61","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1067\/j.cpsurg.2007.07.001","volume":"44","author":"Franz MG","year":"2007","journal-title":"Curr Probl Surg"},{"issue":"6","key":"B62","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1111\/j.1524-475X.2006.00176.x","volume":"14","author":"Steed DL","year":"2006","journal-title":"Wound Repair Regen"},{"key":"B63","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1742-481X.2012.01097.x","volume":"9","author":"Leaper DJ","year":"2012","journal-title":"Int Wound J"},{"issue":"1","key":"B64","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1742-481x.2004.00008.x","volume":"1","author":"Schultz GS","year":"2004","journal-title":"Int Wound J"},{"issue":"1","key":"B65","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1097\/01.ASW.0000549612.44844.75","volume":"32","author":"Hermans MH.","year":"2019","journal-title":"Adv Skin Wound Care"},{"issue":"7","key":"B66","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1089\/wound.2014.0557","volume":"4","author":"Percival SL","year":"2015","journal-title":"Adv Wound Care"},{"issue":"6","key":"B67","doi-asserted-by":"crossref","first-page":"256","DOI":"10.12968\/jowc.2009.18.6.42805","volume":"18","author":"Ahmadi H","year":"2009","journal-title":"J Wound Care"},{"issue":"3","key":"B68","first-page":"211","volume":"156","author":"Alsbj\u00f6rn BF","year":"1990","journal-title":"Acta Chir Scand"},{"issue":"3","key":"B69","first-page":"310","volume":"88","author":"Cuomo R","year":"2017","journal-title":"Acta Biomed"},{"issue":"8","key":"B70","doi-asserted-by":"crossref","first-page":"359","DOI":"10.12968\/jowc.2012.21.8.359","volume":"21","author":"Rippon M","year":"2012","journal-title":"J Wound Care"},{"issue":"5","key":"B71","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1046\/j.1365-4362.1998.00415.x","volume":"37","author":"Hansson C","year":"1998","journal-title":"Int J Dermatol"},{"issue":"3","key":"B72","doi-asserted-by":"crossref","first-page":"129","DOI":"10.12968\/jowc.2007.16.3.27015","volume":"16","author":"Lazareth I","year":"2007","journal-title":"J Wound Care"},{"key":"B73","first-page":"1e-S-32e-S","volume":"117","author":"Broughton G","year":"2006","journal-title":"Plast Reconstr Surg"},{"issue":"1","key":"B74","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.suc.2016.08.013","volume":"97","author":"Childs DR","year":"2017","journal-title":"Surg Clin North Am"},{"issue":"5","key":"B75","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1177\/147323000903700531","volume":"37","author":"Velnar T","year":"2009","journal-title":"J Int Med Res"}],"container-title":["Journal of Wound Care"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/pdf\/10.12968\/jowc.2022.31.10.816","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,14]],"date-time":"2022-10-14T23:02:51Z","timestamp":1665788571000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/10.12968\/jowc.2022.31.10.816"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,2]]},"references-count":74,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,10,2]]}},"alternative-id":["10.12968\/jowc.2022.31.10.816"],"URL":"https:\/\/doi.org\/10.12968\/jowc.2022.31.10.816","relation":{},"ISSN":["0969-0700","2052-2916"],"issn-type":[{"value":"0969-0700","type":"print"},{"value":"2052-2916","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,2]]}}}