{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T09:06:03Z","timestamp":1648890363834},"reference-count":11,"publisher":"Mark Allen Group","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Wound Care"],"published-print":{"date-parts":[[2022,3,2]]},"abstract":"<jats:p> Chronic venous skin lesions heal quickly with compression therapy and wound bed preparation. However, there are conditions in which the tissue repair process is more difficult, such as Meleda disease. Meleda disease is a rare genetic pathology, transmitted with an autosomal recessive gene with a prevalence of 1:100 000; it is also called palmoplantar keratoderma. In this pathology, there is a state of chronic inflammation, an alteration of the extracellular matrix and migration of fibroblasts and keratinocytes, which block the proliferative phase of the tissue repair process. Through targeted interventions and the use of bioactive dressings, it is possible to heal the venous ulcer, although this can take a long time. The authors report their experience in relation to a patient with Meleda disease and venous ulceration of seven years. <\/jats:p>","DOI":"10.12968\/jowc.2022.31.3.224","type":"journal-article","created":{"date-parts":[[2022,2,24]],"date-time":"2022-02-24T12:28:36Z","timestamp":1645705716000},"page":"224-228","source":"Crossref","is-referenced-by-count":0,"title":["Treatment of a chronic skin lesion in the lower limb in Meleda disease"],"prefix":"10.12968","volume":"31","author":[{"given":"Giuseppe","family":"Nebbioso","sequence":"first","affiliation":[{"name":"Azienda Sanitaria Locale Napoli \u2013 Centro Riparazione Tessutale DSB, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viviana","family":"Nebbioso","sequence":"additional","affiliation":[{"name":"University Federico II Napoli, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Petrella","sequence":"additional","affiliation":[{"name":"Azienda Sanitaria Napoli 3 Sud, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5130","reference":[{"issue":"1","key":"B1","first-page":"17","volume":"8","author":"Gjurasi\u0107 M.","year":"2010","journal-title":"Acta Med Hist Adriat"},{"issue":"6","key":"B2","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/sj.ejhg.5200254","volume":"6","author":"Fischer J","year":"1998","journal-title":"Eur J Hum Genet"},{"key":"B3","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1002\/eji.1830270718","volume":"27","author":"Kondo S","year":"1997","journal-title":"Eur J Immunol"},{"issue":"6","key":"B4","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1111\/j.0022-202X.2005.23973.x","volume":"125","author":"Arredondo J","year":"2005","journal-title":"J Invest Dermatol"},{"key":"B5","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1046\/j.1524-475X.11.s2.1.x","volume":"11","author":"Schultz GS","year":"2003","journal-title":"Wound Repair Regen"},{"issue":"8","key":"B6","doi-asserted-by":"crossref","first-page":"512","DOI":"10.12968\/jowc.2018.27.8.512","volume":"27","author":"Ricci E.","year":"2018","journal-title":"J Wound Care"},{"issue":"1","key":"B7","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.cnc.2016.09.009","volume":"29","author":"Cefalu JE","year":"2017","journal-title":"Crit Care Nurs Clin North Am"},{"key":"B8","first-page":"1","volume":"8","author":"Carnali M","year":"2010","journal-title":"Acta Vulnologica"},{"key":"B9","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1126\/science.276.5309.75","volume":"276","author":"Martin P.","year":"1997","journal-title":"Science"},{"issue":"34","key":"B10","doi-asserted-by":"crossref","first-page":"8938","DOI":"10.1016\/j.biomaterials.2011.08.025","volume":"32","author":"van der Smissen A","year":"2011","journal-title":"Biomaterials"},{"issue":"2","key":"B11","first-page":"168","volume":"12","author":"Belvedere R","year":"2018","journal-title":"Cell Adh Migr"}],"container-title":["Journal of Wound Care"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/pdf\/10.12968\/jowc.2022.31.3.224","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,24]],"date-time":"2022-02-24T12:33:40Z","timestamp":1645706020000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/10.12968\/jowc.2022.31.3.224"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,2]]},"references-count":11,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3,2]]}},"alternative-id":["10.12968\/jowc.2022.31.3.224"],"URL":"https:\/\/doi.org\/10.12968\/jowc.2022.31.3.224","relation":{},"ISSN":["0969-0700","2052-2916"],"issn-type":[{"value":"0969-0700","type":"print"},{"value":"2052-2916","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,2]]}}}