{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T18:38:47Z","timestamp":1769107127603,"version":"3.49.0"},"reference-count":37,"publisher":"Mark Allen Group","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Wound Care"],"published-print":{"date-parts":[[2022,5,2]]},"abstract":"<jats:p> Patients with chronic granulomatous disease, a primary immunodeficiency, experience granulomatous complications and recurrent life-threatening opportunistic bacterial and fungal infections. In this article, we report on a case of invasive aspergillosis in an eight-year-old boy with chronic granulomatous disease, who presented with pleural effusion and pneumonia, cerebral venous sinus thrombosis, and unusual skin lesions caused by Aspergillus fumigatus. Antifungal treatment with itraconazole and other antifungal agents, along with interferon-\u03b3, was ineffective and the patient eventually died from cerebral venous sinus thrombosis, and intracerebral haemorrhage following increased intracranial pressure after one month. The diagnosis of invasive aspergillosis should be considered early in children presenting with invasive fungal infections, particularly those involving the central nervous system. <\/jats:p>","DOI":"10.12968\/jowc.2022.31.5.427","type":"journal-article","created":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T11:39:07Z","timestamp":1652787547000},"page":"427-431","source":"Crossref","is-referenced-by-count":4,"title":["Fatal invasive aspergillosis in a child with chronic granulomatous disease"],"prefix":"10.12968","volume":"31","author":[{"given":"Hasti Kamali","family":"Sarvestani","sequence":"first","affiliation":[{"name":"Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saham","family":"Ansari","sequence":"additional","affiliation":[{"name":"Department of Medical Parasitology and Mycology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nima","family":"Parvaneh","sequence":"additional","affiliation":[{"name":"Division of Allergy and Clinical Immunology, Department of Pediatrics, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bahareh","family":"Yaghmaie","sequence":"additional","affiliation":[{"name":"Division of Allergy and Clinical Immunology, Department of Pediatrics, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bahram","family":"Ahmadi","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Sciences, School of Para-Medicine, Bushehr University of Medical Sciences, Bushehr, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5130","reference":[{"issue":"3","key":"B1","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1097\/00005792-200005000-00004","volume":"79","author":"Segal BH","year":"2000","journal-title":"Medicine (Baltimore)"},{"issue":"7","key":"B2","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1097\/DAD.0b013e3182562451","volume":"34","author":"Khemiri M","year":"2012","journal-title":"Am J Dermatopathol"},{"issue":"4","key":"B3","doi-asserted-by":"crossref","first-page":"241","DOI":"10.3109\/15513815.2012.721479","volume":"32","author":"Sfaihi L","year":"2013","journal-title":"Fetal Pediatr Pathol"},{"issue":"1","key":"B4","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1186\/s12879-018-3451-8","volume":"18","author":"Mortaz E","year":"2018","journal-title":"BMC Infect Dis"},{"issue":"4","key":"B5","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/S0891-5520(02)00035-1","volume":"16","author":"Marr KA","year":"2002","journal-title":"Infect Dis Clin North Am"},{"issue":"6","key":"B6","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1097\/QCO.0b013e328358b0a4","volume":"25","author":"Falcone EL","year":"2012","journal-title":"Curr Opin Infect Dis"},{"issue":"2","key":"B7","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3390\/jof2020015","volume":"2","author":"King J","year":"2016","journal-title":"J Fungi (Basel)"},{"issue":"1","key":"B8","first-page":"55","volume":"6","author":"Tavakoli M","year":"2020","journal-title":"Curr Med Mycol"},{"issue":"3","key":"B9","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.jiac.2013.10.008","volume":"20","author":"Saito S","year":"2014","journal-title":"J Infect Chemother"},{"issue":"4","key":"B10","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1093\/cid\/ciw326","volume":"63","author":"Patterson TF","year":"2016","journal-title":"Clin Infect Dis"},{"issue":"4","key":"B11","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1128\/aem.61.4.1323-1330.1995","volume":"61","author":"Glass NL","year":"1995","journal-title":"Appl Environ Microbiol"},{"key":"B12","unstructured":"Clinical and Laboratory Standards Institute (CLSI). Reference Method for broth dilution antifungal susceptibility testing of filamentous fungi; approved standard\u2014second edition. CLSI Document M38-A2. CLSI, 2008"},{"issue":"3","key":"B13","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/sj.jp.7210708","volume":"22","author":"Herman TE","year":"2002","journal-title":"J Perinatol"},{"issue":"1","key":"B14","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/pbc.20426","volume":"47","author":"Alsultan A","year":"2006","journal-title":"Pediatr Blood Cancer"},{"issue":"2","key":"B15","first-page":"85","volume":"5","author":"Khalilzadeh S","year":"2006","journal-title":"Iran J Allergy Asthma Immunol"},{"issue":"3","key":"B16","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s10875-006-9017-3","volume":"26","author":"Tafti SF","year":"2006","journal-title":"J Clin Immunol"},{"issue":"2","key":"B17","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1097\/MAJ.0b013e31823484de","volume":"343","author":"Kaufmann I","year":"2012","journal-title":"Am J Med Sci"},{"issue":"11","key":"B18","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1007\/s10096-003-1007-2","volume":"22","author":"Sambatakou H","year":"2003","journal-title":"Eur J Clin Microbiol Infect Dis"},{"issue":"4","key":"B19","doi-asserted-by":"crossref","first-page":"e233","DOI":"10.1111\/j.1439-0507.2009.01835.x","volume":"54","author":"Mortensen KL","year":"2011","journal-title":"Mycoses"},{"issue":"3","key":"B20","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1097\/00005792-200005000-00003","volume":"79","author":"Winkelstein JA","year":"2000","journal-title":"Medicine (Baltimore)"},{"issue":"4","key":"B21","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1097\/00006123-200204000-00036","volume":"50","author":"Erdogan E","year":"2002","journal-title":"Neurosurgery"},{"key":"B22","doi-asserted-by":"crossref","first-page":"S247","DOI":"10.1080\/13693780400025203","volume":"43","author":"Almyroudis N","year":"2005","journal-title":"Med Mycol"},{"issue":"6","key":"B23","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1542\/peds.113.6.1765","volume":"113","author":"Goodkin HP","year":"2004","journal-title":"Pediatrics"},{"issue":"12","key":"B24","doi-asserted-by":"crossref","first-page":"e159","DOI":"10.1093\/cid\/cir731","volume":"53","author":"Blumental S","year":"2011","journal-title":"Clin Infect Dis"},{"issue":"8","key":"B25","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1089\/jir.2015.0095","volume":"36","author":"Henriet SS","year":"2016","journal-title":"J Interferon Cytokine Res"},{"issue":"6","key":"B26","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.pediatrneurol.2010.06.020","volume":"43","author":"Roxo P","year":"2010","journal-title":"Pediatr Neurol"},{"issue":"3","key":"B27","doi-asserted-by":"crossref","first-page":"537","DOI":"10.3109\/13693780903325290","volume":"48","author":"Al-Tawfiq JA","year":"2010","journal-title":"Med Mycol"},{"issue":"2","key":"B28","doi-asserted-by":"crossref","first-page":"94","DOI":"10.4103\/2006-8808.92802","volume":"3","author":"Tahir C","year":"2011","journal-title":"J Surg Tech Case Rep"},{"issue":"5","key":"B29","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.jaad.2009.02.052","volume":"61","author":"Marcoux D","year":"2009","journal-title":"J Am Acad Dermatol"},{"issue":"4","key":"B30","doi-asserted-by":"crossref","first-page":"213","DOI":"10.3390\/jof6040213","volume":"6","author":"Vahedi-Shahandashti R","year":"2020","journal-title":"J Fungi (Basel)"},{"issue":"5","key":"B31","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1086\/324620","volume":"34","author":"Denning DW","year":"2002","journal-title":"Clin Infect Dis"},{"issue":"10","key":"B32","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1086\/514352","volume":"44","author":"Anaissie EJ.","year":"2007","journal-title":"Clin Infect Dis"},{"key":"B33","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3389\/fimmu.2020.00038","volume":"11","author":"Danion F","year":"2020","journal-title":"Front Immunol"},{"issue":"24","key":"B34","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.1056\/NEJMoa021931","volume":"348","author":"Gallin JI","year":"2003","journal-title":"N Engl J Med"},{"issue":"6","key":"B35","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1056\/NEJMoa020191","volume":"347","author":"Herbrecht R","year":"2002","journal-title":"N Engl J Med"},{"issue":"1","key":"B36","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1590\/S0036-46652009000100009","volume":"51","author":"Martinez R","year":"2009","journal-title":"Rev Inst Med Trop S\u00e3o Paulo"},{"issue":"2","key":"B37","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s00381-009-1003-7","volume":"26","author":"Patiroglu T","year":"2010","journal-title":"Childs Nerv Syst"}],"container-title":["Journal of Wound Care"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/pdf\/10.12968\/jowc.2022.31.5.427","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T11:43:36Z","timestamp":1652787816000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/10.12968\/jowc.2022.31.5.427"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,2]]},"references-count":37,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5,2]]}},"alternative-id":["10.12968\/jowc.2022.31.5.427"],"URL":"https:\/\/doi.org\/10.12968\/jowc.2022.31.5.427","relation":{},"ISSN":["0969-0700","2052-2916"],"issn-type":[{"value":"0969-0700","type":"print"},{"value":"2052-2916","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,2]]}}}