{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T11:39:02Z","timestamp":1788521942801,"version":"build-2803163510"},"reference-count":28,"publisher":"Mark Allen Group","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Wound Care"],"published-print":{"date-parts":[[2022,9,2]]},"abstract":"<jats:sec><jats:title>Objective:<\/jats:title><jats:p> In this study, the effects of resveratrol topical ointment on wound contraction and histopathology of full-thickness cutaneous burn wounds were evaluated. <\/jats:p><\/jats:sec><jats:sec><jats:title>Method:<\/jats:title><jats:p> Adult albino rats were grouped into four equal-sized groups of 15 rats each, as follows: Group A\u2014no wound, no treatment (control); Group B\u20141% silver sulphadiazine; Group C\u20145% resveratrol, and Group D\u2014wound without treatment (control). A burn wound measuring 23.5mm was created on the skin at the dorsum of all rats in groups B\u2014D after shaving. The percentage of wound contraction was measured using a digital Vernier Caliper on days 1, 3, 5, 7, 10, 14, 16, 18 and 21, post-wounding. From each group, five rats were then euthanised and tissue samples of the skin, liver and kidney were collected in 10% buffered formalin for histopathology. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> The percentage of wound contraction was significant (p&lt;0.05) on 7, 14 and 18 days post treatment. Histopathologically, 5% resveratrol topical ointment application resulted in a thicker epidermis with neovascularisation and an increased collagen distribution. Resveratrol topical ointment ameliorated the extent of hepatocellular and nephrotubular injuries following burn-induced hepatocellular and acute kidney injuries. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> In this study, topical application of 5% resveratrol ointment appeared to enhance burn wound healing by increasing the rate of wound contraction through collagen fibre synthesis, granulation tissue formation and epithelial regeneration. <\/jats:p><\/jats:sec>","DOI":"10.12968\/jowc.2022.31.9.780","type":"journal-article","created":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T23:02:56Z","timestamp":1663369376000},"page":"780-791","source":"Crossref","is-referenced-by-count":4,"title":["Effects of resveratrol topical ointment on wound healing of full-thickness cutaneous burns in albino rats"],"prefix":"10.12968","volume":"31","author":[{"given":"Daniel T","family":"Yoksa","sequence":"first","affiliation":[{"name":"Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Maiduguri, PMB 1069 Maiduguri, Borno State"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuf","family":"Abba","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Maiduguri, PMB 1069 Maiduguri, Borno State"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bala U","family":"Shamaki","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Maiduguri, PMB 1069 Maiduguri, Borno State"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ngamarju A","family":"Satumari","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Science, Faculty of Allied Health Sciences, University of Maiduguri, PMB 1069 Maiduguri, Borno State"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5130","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1590\/S0102-86502012000600010"},{"key":"B2","doi-asserted-by":"crossref","first-page":"1914732","DOI":"10.1155\/2017\/1914732","volume":"2017","author":"Karunanidhi A","year":"2017","journal-title":"Evid Based Complement Alternat Med"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1177\/147323000903700531"},{"issue":"3","key":"B4","first-page":"713","volume":"19","author":"Liu ML","year":"2014","journal-title":"J BUON"},{"key":"B5","doi-asserted-by":"crossref","first-page":"184241","DOI":"10.1155\/2015\/184241","volume":"2015","author":"Abba Y","year":"2015","journal-title":"Adv Virol"},{"issue":"3","key":"B6","doi-asserted-by":"crossref","DOI":"10.1590\/S1984-82502015000300002","volume":"51","author":"Ruivo J","year":"2015","journal-title":"Braz J Pharm Sci"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12635"},{"issue":"1","key":"B8","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/iwj.13601","volume":"19","author":"Hecker A","year":"2022","journal-title":"Int Wound J"},{"issue":"4","key":"B9","first-page":"128","volume":"53","author":"G\u00fcnal MY","year":"2019","journal-title":"Deri Hastalikiari Frengi Arsivi"},{"issue":"8","key":"B10","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/S0891-5849(02)00999-1","volume":"33","author":"Khanna S","year":"2002","journal-title":"Free Radic Biol Med"},{"issue":"4","key":"B11","doi-asserted-by":"crossref","DOI":"10.5812\/modernc.66118","volume":"14","author":"Afshar M","year":"2017","journal-title":"Modern Care J"},{"key":"B12","volume-title":"ACS surgery: principles and practice","author":"Sterling JP","year":"2010"},{"issue":"1","key":"B13","first-page":"2","volume":"18","author":"Hosseinimehr SJ","year":"2010","journal-title":"Acta Dermatovenerol Croat"},{"issue":"4","key":"B14","doi-asserted-by":"crossref","first-page":"317","DOI":"10.5999\/aps.2014.41.4.317","volume":"41","author":"Cai EZ","year":"2014","journal-title":"Arch Plast Surg"},{"issue":"6","key":"B15","first-page":"107","volume":"7","author":"Guo HF","year":"2017","journal-title":"Int J Burns Trauma"},{"key":"B16","first-page":"3507","volume":"9","author":"Albaayit SFA","year":"2015","journal-title":"Drug Des Devel Ther"},{"issue":"6","key":"B17","doi-asserted-by":"crossref","first-page":"378","DOI":"10.31254\/phyto.2014.3601","volume":"3","author":"Bhatia N","year":"2014","journal-title":"J Phytopharmacol"},{"issue":"4","key":"B18","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.burns.2003.12.006","volume":"30","author":"Infanger M","year":"2004","journal-title":"Burns"},{"issue":"4","key":"B19","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1083\/jcb.124.4.401","volume":"124","author":"Grinnel F.","year":"1994","journal-title":"J Cell Biol"},{"issue":"2","key":"B20","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.3892\/mmr.2015.4681","volume":"13","author":"Lin L. 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