{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T11:31:18Z","timestamp":1781091078282,"version":"3.54.1"},"reference-count":28,"publisher":"Mark Allen Group","issue":"Sup3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Wound Care"],"published-print":{"date-parts":[[2022,3,1]]},"abstract":"<jats:sec><jats:title>Objective:<\/jats:title><jats:p> Osteomyelitis may complicate diabetic foot ulcers (DFUs). As a new inflammation-based prognostic factor, CRP:albumin ratio's significance is not known in osteomyelitis among patients with or without diabetes. <\/jats:p><\/jats:sec><jats:sec><jats:title>Method:<\/jats:title><jats:p> Patients with type 2 diabetes and DFUs were divided into two groups: group 1 (n=47) comprised patients without osteomyelitis, and group 2 (n=50) comprised patients with osteomyelitis. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> Erythrocyte sedimentation rate (ESR) (88.5\u00b123.0 versus 42.0\u00b122.2), white blood cell count (WBC) (14.7\u00b16.9x10<jats:sup>3<\/jats:sup> versus 10.0\u00b14.4x10<jats:sup>3<\/jats:sup>), C-reactive protein (CRP) level (15.6\u00b19.9 versus 2.4\u00b13.3) and CRP:albumin ratio (6.6\u00b14.9 versus 0.7\u00b11.0) were significantly higher, and albumin level was significantly lower in group 2 compared to group 1 (p&lt;0.001 for all). The presence of osteomyelitis was significantly and positively correlated with ESR (r=0.721; p&lt;0.001), WBC (r=0.380; p&lt;0.001), CRP (r=0.667; p&lt;0.001) and CRP:albumin ratio (r=0.638; p&lt;0.001), and negatively correlated with albumin (r=\u22120.590; p&lt;0.001). A CRP:albumin ratio of 1.74 or above could predict osteomyelitis with 92.0% sensitivity, 80.9% specificity, and the best area under the curve (AUC) score (AUC=0.957; 95% CI: 0.924\u20130.991). ESR (odds ratio (OR): 1.071 (1.025\u20131.119); p=0.02) and CRP:albumin ratio (OR: 2.65 (1.437\u20134.885); p=0.002) were independent predictors in the final model for stepwise linear regression analyses for the estimation of osteomyelitis. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> CRP:albumin ratio is a cheap and repeatable inflammatory marker and can successfully detect osteomyelitis in patients with DFU. <\/jats:p><\/jats:sec>","DOI":"10.12968\/jowc.2022.31.sup3.s25","type":"journal-article","created":{"date-parts":[[2022,2,24]],"date-time":"2022-02-24T12:42:16Z","timestamp":1645706536000},"page":"S25-S28","source":"Crossref","is-referenced-by-count":16,"title":["Pilot study of the diagnostic value of CRP:albumin ratio for osteomyelitis in patients with diabetic foot ulcers"],"prefix":"10.12968","volume":"31","author":[{"given":"Mehmet","family":"Ali Eren","sequence":"first","affiliation":[{"name":"Harran University, School of Medicine, Department 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