{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:46:19Z","timestamp":1792291579833,"version":"4.4.0"},"reference-count":29,"publisher":"Mark Allen Group","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Wound Care"],"published-print":{"date-parts":[[2026,1,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Diabetic foot ulcer (DFU) is one of the most common complications of diabetes, and causes significant morbidity, mortality and healthcare expenditure. Multidrug-resistant organism (MDRO) infection is considered a major threat to the treatment of DFUs. This study investigated the risk factors for MDRO infections in DFUs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method:<\/jats:title>\n                    <jats:p>This was a retrospective case\u2013control study. Patients diagnosed with DFU and MDRO infections were included in the observation group. The same number of patients hospitalised during the same period and who were diagnosed with DFU but without MDRO infection were matched and selected as the control group. Binary logistic regression analysis was performed to evaluate the risk factors for multidrug-resistant organism (MDRO) infections in DFUs by analysing the clinical data. The receiver operating characteristic (ROC) curve was used for evaluation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The electronic medical records of 110 patients (55 in each group, with similar sex and age) were reviewed. The results of binary logistic regression analysis showed that: history of antibiotic exposure (odds ratio (OR)=11.878; 95% confidence interval (CI): 3.064, 46.046; p&lt;0.001); history of hospitalisation within one year (OR=3.198; 95% CI: 1.156, 8.846; p=0.025); hypertension (OR=3.976; 95% CI: 1.444, 10.951; p=0.008); and osteomyelitis (OR=21.667; 95% CI: 3.427, 137.002; p=0.001) were significant risk factors for MDRO infection in patients with a DFU. The logistic regression model for MDRO infection in patients with a DFU was fitted as follows: Logit (P) = (\u20133.482) + (2.475) \u00d7 history of antibiotic exposure + (1.163) \u00d7 history of hospitalisation within 1 year + (1.380) \u00d7 hypertension + (3.076) \u00d7 osteomyelitis. The ROC curve evaluation model was plotted. The area under the curve was 0.861 (95% CI: 0.794, 0.927; p&lt;0.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The findings of this study showed that history of antibiotic exposure, history of hospitalisation within one year, hypertension, and osteomyelitis in combination were the risk factors for MDRO infections in patients with DFUs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.12968\/jowc.2023.0041","type":"journal-article","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T16:49:07Z","timestamp":1768322947000},"page":"59-67","source":"Crossref","is-referenced-by-count":2,"title":["Microbiological characteristics and risk factors for multidrug-resistant organism infections in diabetic foot ulcer"],"prefix":"10.12968","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5530-5985","authenticated-orcid":false,"given":"Yiru","family":"Bao","sequence":"first","affiliation":[{"name":"Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, 100010, People's Republic of China"},{"name":"Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Shi","sequence":"additional","affiliation":[{"name":"Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, People's Republic of China"},{"name":"The Fourth Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, 300451, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaojun","family":"Zhu","sequence":"additional","affiliation":[{"name":"Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, 300150, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Liang","sequence":"additional","affiliation":[{"name":"Guangdong Pharmaceutical University, Guangzhou, 510006, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Xu","sequence":"additional","affiliation":[{"name":"Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, People's Republic of China"},{"name":"Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, 300150, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaohui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, 300150, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5130","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.2337\/dc19-1614"},{"issue":"2","key":"B2","first-page":"92","volume":"11","author":"Chinese Medical Association Diabetes Branch, Chinese Medical Association Infectious Diseases Branch, Chinese Medical Association Tissue Repair and Regeneration Branch","year":"2019","journal-title":"Chin J Diabetes Mellitus"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-024-06102-x"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiph.2017.10.006"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2024.1521199"},{"issue":"5","key":"B6","first-page":"394","volume":"74","author":"Kow RY","year":"2019","journal-title":"Med J Malaysia"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.5704\/MOJ.2203.003"},{"key":"B8","unstructured":"World Health Organization. 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