{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T02:38:59Z","timestamp":1755225539437,"version":"3.43.0"},"reference-count":23,"publisher":"Mark Allen Group","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Wound Care"],"published-print":{"date-parts":[[2025,8,2]]},"abstract":"<jats:sec><jats:title>Objective:<\/jats:title><jats:p> To verify the utility and accuracy of periwound regional oxygen saturation (rSO<jats:sub>2<\/jats:sub>) as a wound healing predictor of toes in patients with chronic limb-threatening ischaemia (CLTI), and compare the results with skin perfusion pressure (SPP) measurements. <\/jats:p><\/jats:sec><jats:sec><jats:title>Method:<\/jats:title><jats:p> Patients with hard-to-heal (chronic) toe wounds and CLTI, and who had undergone toe rSO<jats:sub>2<\/jats:sub> (near wound), forefoot rSO<jats:sub>2<\/jats:sub> and SPP measurements, were retrospectively selected. Following the measurements, the patients were treated conservatively, and the progress of wound healing was evaluated 28\u201391 days after the rSO<jats:sub>2<\/jats:sub>\/SPP measurements. Toe wounds were classified into two groups: healing and non-healing. Receiver operating characteristic curves were created for rSO<jats:sub>2<\/jats:sub>\/SPP to evaluate the accuracy of the wound healing prediction index, and the area under the curve (AUC) was also evaluated. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> A total of 118 toes from 76 limbs were included in the evaluation and analysis. The AUC of periwound rSO<jats:sub>2<\/jats:sub> was 0.938 (cut-off value: 44%; sensitivity: 0.955; specificity: 0.793). The AUC of plantar forefoot rSO<jats:sub>2<\/jats:sub> and SPP were 0.789 and 0.786, respectively. The dorsal forefoot rSO<jats:sub>2<\/jats:sub> and SPP demonstrated lower accuracy as wound healing predictors compared with the plantar side (AUC: 0.551 and 0.758, respectively). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> In this retrospective study, periwound rSO<jats:sub>2<\/jats:sub> was a highly accurate predictor of toe wound healing in patients with CLTI. Both plantar forefoot rSO<jats:sub>2<\/jats:sub> and SPP demonstrated moderate-to-high accuracy as predictors of toe wound healing, but less than that for periwound rSO<jats:sub>2<\/jats:sub>. Prospective studies in controlled populations are required. New devices that can measure periwound perfusion may provide more accurate wound healing predictions. <\/jats:p><\/jats:sec>","DOI":"10.12968\/jowc.2023.0042","type":"journal-article","created":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T13:38:02Z","timestamp":1755092282000},"page":"580-588","source":"Crossref","is-referenced-by-count":0,"title":["Effectiveness of periwound regional oxygen saturation as a wound healing predictor of toes in patients with chronic limb-threatening ischaemia"],"prefix":"10.12968","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3285-5428","authenticated-orcid":false,"given":"Yu","family":"Kagaya","sequence":"first","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Kyorin University Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norihiko","family":"Ohura","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Kyorin University Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Morishige","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Kyorin University Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Take-e","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Kyorin University Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mine","family":"Ozaki","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Kyorin University Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5130","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13953"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.13194"},{"issue":"3","key":"B3","first-page":"159","volume":"101","author":"Bowers S","year":"2020","journal-title":"Am Fam Physician"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2013.08.003"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2016.10.026"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2015.10.004"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1007\/s00772-018-0368-x"},{"issue":"4","key":"B8","first-page":"330","volume":"8","author":"Pan X","year":"2018","journal-title":"Biomed Rep"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2013.11.011"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3400\/avd.oa.20-00132"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3400\/avd.oa.18-00117"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61602-X"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2014.07.014"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2019.05.006"},{"issue":"9","key":"B15","first-page":"CD010680","volume":"9","author":"Crawford F","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1097\/WON.0b013e3182a9a7bf"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2018.12.008"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.3400\/avd.oa.11.00022"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.3400\/avd.oa.13-00062"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2016.62220"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1177\/1479164120928868"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.12.6.373"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2017.10.020"}],"container-title":["Journal of Wound Care"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/pdf\/10.12968\/jowc.2023.0042","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T13:38:09Z","timestamp":1755092289000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/10.12968\/jowc.2023.0042"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,2]]},"references-count":23,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8,2]]}},"alternative-id":["10.12968\/jowc.2023.0042"],"URL":"https:\/\/doi.org\/10.12968\/jowc.2023.0042","relation":{},"ISSN":["0969-0700","2052-2916"],"issn-type":[{"value":"0969-0700","type":"print"},{"value":"2052-2916","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,2]]}}}