{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T02:38:59Z","timestamp":1755225539484,"version":"3.43.0"},"reference-count":50,"publisher":"Mark Allen Group","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Wound Care"],"published-print":{"date-parts":[[2025,8,2]]},"abstract":"<jats:sec><jats:title>Objective:<\/jats:title><jats:p> Remote ischaemic conditioning (RIC) is known to have a positive impact on heart muscle cells, kidney and liver cells. RIC improves microcirculation in healthy skin. Microcirculation is a crucial factor in wound healing. This study examined the microcirculatory effects of RIC in hard-to-heal (chronic) wounds based on the hypothesis that RIC improves cutaneous microcirculation in hard-to-heal wounds. <\/jats:p><\/jats:sec><jats:sec><jats:title>Method:<\/jats:title><jats:p> Patients with hard-to-heal wounds (&gt;3 weeks) participated in the study. RIC comprised three ischaemia cycles (five-minute inflation of blood pressure cuff to 200mmHg), each followed by a 10-minute reperfusion phase on a healthy upper limb. After the third and final ischaemia cycle, a reperfusion of 20 minutes ensued. Microcirculation was continuously recorded through a combined laser Doppler and white light spectrometry. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> The cohort comprised 20 patients. In hard-to-heal wounds, oxygen saturation in a 6\u20138mm tissue depth was increased by a maximum of 11.2% (percentage change from baseline; p&lt;0.02) and capillary blood flow was increased by a maximum of 47.7% (p&lt;0.0001). There was no significant change of the postcapillary venous filling pressure. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> The results of this study showed that RIC enhanced microcirculation in hard-to-heal wounds by elevating capillary blood flow and oxygen saturation. <\/jats:p><\/jats:sec>","DOI":"10.12968\/jowc.2023.0134","type":"journal-article","created":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T13:38:02Z","timestamp":1755092282000},"page":"631-636","source":"Crossref","is-referenced-by-count":0,"title":["Acute microcirculatory effects of remote ischaemic conditioning in hard-to-heal wounds"],"prefix":"10.12968","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0517-2103","authenticated-orcid":false,"given":"Julia","family":"Lucius","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery, Hand Surgery and Burn Care Unit, University Hospital Schleswig-Holstein, Campus L\u00fcbeck, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mascha","family":"Gro\u00df","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Hand Surgery and Burn Care Unit, University Hospital Schleswig-Holstein, Campus L\u00fcbeck, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Schleusser","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Hand Surgery and Burn Care Unit, University Hospital Schleswig-Holstein, Campus L\u00fcbeck, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henriette","family":"Deichmann","sequence":"additional","affiliation":[{"name":"Department of Surgery, University Hospital Schleswig-Holstein, Campus L\u00fcbeck, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Horn","sequence":"additional","affiliation":[{"name":"Department of Surgery, University Hospital Schleswig-Holstein, Campus L\u00fcbeck, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raphael R","family":"Tasar","sequence":"additional","affiliation":[{"name":"Johanniter Krankenhaus, Bonn, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan-Oluf","family":"Jensen","sequence":"additional","affiliation":[{"name":"Helios Klinik Schwerin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix H","family":"Stang","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Hand Surgery and Burn Care Unit, University Hospital Schleswig-Holstein, Campus L\u00fcbeck, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Mail\u00e4nder","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Hand Surgery and Burn Care Unit, University Hospital Schleswig-Holstein, Campus L\u00fcbeck, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Kisch","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Hand Surgery and Burn Care Unit, University Hospital Schleswig-Holstein, Campus L\u00fcbeck, Germany"},{"name":"Department of Plastic, Reconstructive and Aesthetic Surgery, Hand Surgery, Praxisklinik Kronshagen, Kiel-Kronshagen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5130","reference":[{"key":"B1","unstructured":"Lippert H (ed). 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