{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:00:20Z","timestamp":1791406820482,"version":"4.3.3"},"reference-count":63,"publisher":"Mark Allen Group","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Wound Care"],"published-print":{"date-parts":[[2024,6,2]]},"abstract":"<jats:sec><jats:title>Objective:<\/jats:title><jats:p> Hard-to-heal (chronic) wounds are common in patients with diabetes and are associated with a decrease in quality of life (QoL). Pathogenic bacteria often colonise hard-to-heal wounds and hinder the healing process which poses a high risk for (systemic) infections. In this study, we aim to prove that probiotics are capable of displacing human pathogenic bacteria, ameliorating inflammation and positively influencing the microenvironment\/microbiome of skin and mucosa. <\/jats:p><\/jats:sec><jats:sec><jats:title>Method:<\/jats:title><jats:p> In this pilot study, patients with diabetes and hard-to-heal wounds with a duration of 2\u2013120 months received an oral multispecies probiotic daily for six months. Changes in oral, stool and wound microbiome were investigated, and the effects of the probiotic intervention on wound healing, periodontitis and wound-specific quality of life (Wound-QOL-17) were analysed throughout the course of this clinical study. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> In total, seven of the 20 patients included were unable to complete the study. After six months of oral probiotic intake supplementation in five out of the remaining 13 patients, the wounds had healed completely. Most patients reported an improvement in wound-specific QoL, with particular positive effects on pain and mobility. Microbiome analysis revealed a reduction in Staphylococcus aureus and Pseudomonas aeruginosa, and Staphylococcus epidermis in healed wounds. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> This findings of this study provide evidence for the beneficial effects of the oral application of a multispecies probiotic over six months in patients with diabetes and hard-to-heal wounds on wound closure, wound microbial pattern, QoL, and on dental health. A randomised, placebo-controlled, double-blinded clinical trial is required to verify the results. <\/jats:p><\/jats:sec>","DOI":"10.12968\/jowc.2023.0302","type":"journal-article","created":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T16:13:30Z","timestamp":1717690410000},"page":"394-407","source":"Crossref","is-referenced-by-count":11,"title":["Effect of oral multispecies probiotic on wound healing, periodontitis and quality of life on patients with diabetes"],"prefix":"10.12968","volume":"33","author":[{"given":"Ewa Klara","family":"Stuermer","sequence":"first","affiliation":[{"name":"Department of Vascular Medicine, University Heart and Vascular Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinna","family":"Bang","sequence":"additional","affiliation":[{"name":"Institute of Clinical Molecular Biology, Kiel University and University Medical Center Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Giessler","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, University Medical Center Hamburg-Eppendorf, Martini Street 52, 20246 Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Smeets","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, University Medical Center Hamburg-Eppendorf, Martini Street 52, 20246 Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toni Maria","family":"Janke","sequence":"additional","affiliation":[{"name":"Health Care Research in Dermatology and Nursing, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filip David","family":"Seki","sequence":"additional","affiliation":[{"name":"Joint Microbiome Facility of the Medical University of Vienna and the University of Vienna, Vienna, Austria"},{"name":"Division of Clinical Microbiology, Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eike Sebastian","family":"Debus","sequence":"additional","affiliation":[{"name":"Department of Vascular Medicine, University Heart and Vascular Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre","family":"Franke","sequence":"additional","affiliation":[{"name":"Institute of Clinical Molecular Biology, Kiel University and University Medical Center Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Augustin","sequence":"additional","affiliation":[{"name":"Health Care Research in Dermatology and Nursing, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5130","reference":[{"issue":"2","key":"B1","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/nrendo.2017.151","volume":"14","author":"Zheng Y","year":"2018","journal-title":"Nat Rev Endocrinol"},{"key":"B2","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.diabres.2017.03.024","volume":"128","author":"Ogurtsova K","year":"2017","journal-title":"Diabetes Res Clin Pract"},{"issue":"1","key":"B3","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1186\/s12955-018-1021-9","volume":"16","author":"Jing X","year":"2018","journal-title":"Health Qual Life Outcomes"},{"key":"B4","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/978-3-031-08491-1_15","volume-title":"Pseudomonas aeruginosa. 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