{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:09:01Z","timestamp":1789085341349,"version":"build-2803163510"},"reference-count":21,"publisher":"Mark Allen Group","issue":"Sup8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Wound Care"],"published-print":{"date-parts":[[2025,8,1]]},"abstract":"\n Objective:<\/jats:title>\n A number of treatments have been developed to treat hard-to-heal (chronic) diabetic foot ulcers (DFUs). This case series the use of ON101\u2014a new topical macrophage regulatory cream for the treatment of DFUs, that helped achieve limb-salvage outcomes with an adequate safety profile.<\/jats:p>\n <\/jats:sec>\n \n Method:<\/jats:title>\n Patients with hard-to-heal DFUs\u2014primarily on the toes and plantar surfaces\u2014were enrolled in the study. After infection control, wound debridement or angioplasty intervention, ON101, containing 1.25% extracts of Plectranthus amboinicus (0.25%) and Centella asiatica (1%), was applied topically to the wounds up to twice daily. The condition of the wounds, complications, healing progression and other details were documented.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n In total, 10 patients, with a mean age of 59.2 years (range: 35\u221277 years), were included in the study following surgical debridement, sequestrectomy or revascularisation. Wound sizes ranged from 1\u201466 cm\n 2<\/jats:sup>\n . After receiving ON101 treatment for durations ranging from 14\u2013264 days, most wounds healed without complications, except for one patient with osteomyelitis who did not fully recover. All patients expressed satisfaction with the outcomes and had no reported complications at the six-month follow-up.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n This case series demonstrated the real-world outcomes of ON101, which exhibited good healing efficacy in the treatment of DFUs, making it a promising strategy for the topical treatment of these ulcers.<\/jats:p>\n <\/jats:sec>","DOI":"10.12968\/jowc.2023.0318","type":"journal-article","created":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T15:31:21Z","timestamp":1755185481000},"page":"lxxiv-lxxx","source":"Crossref","is-referenced-by-count":3,"title":["Enhancing diabetic foot wound healing with topical macrophage-regulating cream (ON101): a case series"],"prefix":"10.12968","volume":"34","author":[{"given":"Kwan Lok Benjamin","family":"Ng","sequence":"first","affiliation":[{"name":"Division of Plastic Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, 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