{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:26:56Z","timestamp":1790641616470,"version":"4.1.0"},"reference-count":17,"publisher":"Mark Allen Group","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Wound Care"],"published-print":{"date-parts":[[2023,11,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Blue light (410\u2013430nm) has been suggested to be effective in the healing process of hard-to-heal wounds. The aim of this study was to test this hypothesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method:<\/jats:title>\n                    <jats:p>This single-centre observational study assessed the efficacy of photobiomodulation with blue light (120 seconds at a distance of 4cm from the wound bed once a week for four weeks) in activating healing in patients with hard-to-heal skin lesions (mean duration 23.9 months) of the lower limb that had not responded to four weeks of standard treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 59 patients were assessed. Wounds were divided into groups according to aetiology: hard-to-heal venous wound (30.5%); hard-to-heal arterial and mixed wounds (16.9%); hard-to-heal inflammatory wound (22.0%); other hard-to-heal wounds (13.6%); and acute wound (16.9%). The mean reduction in wound area at the end of the four-week treatment period with blue light compared with baseline was 51.38% (p&lt;0.001) across all wounds. Among subgroups, the best performance was obtained for hard-to-heal venous wounds, achieving a 63.36% (p&lt;0.001) mean reduction in wound size, and acute wounds, achieving a mean reduction of 82.76% (p&lt;0.001). The greatest mean change in wound bed score was seen at the end of the four-week treatment period with blue light, with an increase in the mean score from 8.6 at baseline to 12.8 at week four (77.2%; p&lt;0.001). There was a clear decrease in pain during blue light treatment, achieving a reduction in the average numeric rating scale (NRS) from 4.3 at baseline to 1.8 at week 4 (53.23%; p &lt;0.001). At week 4, the highest proportion of complete healing was seen in acute (100.0%) and venous wounds (83.3%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Based on these results, photobiomodulation with blue light appears to reactivate the healing process in acute and hard-to-heal wounds that do not respond to standard treatment. Photobiomodulation with blue light treatment is easy to perform and safe, with no reported adverse events or side-effects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.12968\/jowc.2023.32.11.695","type":"journal-article","created":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T21:46:25Z","timestamp":1698788785000},"page":"695-703","source":"Crossref","is-referenced-by-count":16,"title":["Blue light photobiomodulation for reactivation of healing in wounds not responding to standard therapy"],"prefix":"10.12968","volume":"32","author":[{"given":"Elia","family":"Ricci","sequence":"first","affiliation":[{"name":"Difficult Wound Healing Unit, St. Luca Clinic, Pecetto Torinese (Turin), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Pittarello","sequence":"additional","affiliation":[{"name":"Difficult Wound Healing Unit, St. Luca Clinic, Pecetto Torinese (Turin), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5130","reference":[{"key":"B1","unstructured":"Labib AM, Winters R. 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