{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T08:45:14Z","timestamp":1782981914937,"version":"3.54.5"},"reference-count":42,"publisher":"Mark Allen Group","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Wound Care"],"published-print":{"date-parts":[[2023,4,2]]},"abstract":"<jats:sec><jats:title>Objective:<\/jats:title><jats:p> To evaluate the clinical efficacy of a new antioxidant therapy for the treatment of complex neuroischaemic diabetic foot ulcers (DFUs). <\/jats:p><\/jats:sec><jats:sec><jats:title>Method:<\/jats:title><jats:p> A prospective case series study has been conducted in patients with complex neuroischaemic DFUs after transmetatarsal amputation. DFUs were locally treated with an antioxidant dressing twice a week for the first two weeks, and then once a week until the end of the study or complete wound closure. Patients were followed-up for eight weeks and assessed weekly to analyse wound outcome. Primary outcomes were the wound closure ratio and percentage of granulation tissue; secondary outcomes were parameters related to wound management, namely, presence of non-viable tissue in the wound bed, levels of maceration and exudates, presence of erythema and pain. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> A total of 20 patients were included with a mean baseline wound area of 20.4cm<jats:sup>2<\/jats:sup>. At 8 weeks, the mean reduction in wound area was 88.1% (p&lt;0.0001) and complete closure was observed in 33% of cases. In addition, there was a mean increase of 94.7% in granulation tissue in the wound bed (p&lt;0.0001). Furthermore, the therapy was associated with a significant percentage reduction in wounds with non-viable tissue, good exudate management, and the maintenance of low levels of maceration, erythema and pain. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> The new antioxidant therapy was associated with good clinical outcomes in large hard-to-heal neuroischaemic DFUs, with significant wound area reduction and granulation tissue formation. The therapy was also found to be safe and perform well from a practical perspective. <\/jats:p><\/jats:sec>","DOI":"10.12968\/jowc.2023.32.4.238","type":"journal-article","created":{"date-parts":[[2023,4,8]],"date-time":"2023-04-08T17:28:35Z","timestamp":1680974915000},"page":"238-246","source":"Crossref","is-referenced-by-count":3,"title":["New antioxidant therapy for hard-to-heal neuroischaemic diabetic foot ulcers with deep exposure"],"prefix":"10.12968","volume":"32","author":[{"given":"Elena","family":"P\u00e9rez-Zabala","sequence":"first","affiliation":[{"name":"Hospital-at-Home Department, Cruces University Hospital, Bizkaia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andima","family":"Basterretxea","sequence":"additional","affiliation":[{"name":"Hospital-at-Home Department, Cruces University Hospital, Bizkaia, 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