{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:38:48Z","timestamp":1790681928880,"version":"4.1.0"},"reference-count":18,"publisher":"Mark Allen Group","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Wound Care"],"published-print":{"date-parts":[[2023,4,2]]},"abstract":"<jats:sec><jats:title>Aim:<\/jats:title><jats:p> Cold atmospheric plasma (CAP) has antimicrobial properties. We studied the safety of a novel CAP device (PLASOMA prototype; Plasmacure, The Netherlands) that is simple to use and could be applied at a patient's home for the treatment of diabetic foot ulcers (DFUs). Secondary objectives were to investigate the effect of CAP on bacterial load and on ulcer size. <\/jats:p><\/jats:sec><jats:sec><jats:title>Method:<\/jats:title><jats:p> We included subjects with non-infected, superficial DFUs and treated them with CAP on a daily basis for 10 days. The primary endpoint was the occurrence of serious adverse device effects (SADE). We defined safety as: \u226410% of patients experiencing a SADE other than infection (non-infectious SADE), and \u226460% of patients developing infection of the foot (infectious serious adverse event (SAE)). <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> We enrolled 20 patients. No SADE occurred, but three infectious SAEs occurred at the site of application within one month of treatment; three SAEs unrelated to treatment occurred, and 55% of subjects reported transient mild adverse device effects. Staphylococcus aureus bacterial load decreased directly after CAP application (p=0.01). The mean decrease of ulcer surface area was 43% (95% confidence interval: 20.2%\u201365.9%). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> CAP treatment in DFUs was safe and well tolerated. Ulcer size and Staphylococcus aureus colonisation decreased during treatment. <\/jats:p><\/jats:sec>","DOI":"10.12968\/jowc.2023.32.4.247","type":"journal-article","created":{"date-parts":[[2023,4,8]],"date-time":"2023-04-08T17:28:35Z","timestamp":1680974915000},"page":"247-251","source":"Crossref","is-referenced-by-count":11,"title":["Cold plasma treatment is safe for diabetic foot ulcers and decreases <i>Staphylococcus aureus<\/i> bacterial load"],"prefix":"10.12968","volume":"32","author":[{"given":"Rimke S","family":"Lagrand","sequence":"first","affiliation":[{"name":"Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Internal Medicine, Amsterdam Movement Sciences, Amsterdam, Netherlands"},{"name":"Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Rehabilitation Medicine, Amsterdam Movement Sciences, De Boelelaan 1117, 1081 HV Amsterdam, Netherlands"},{"name":"Amsterdam UMC, University of Amsterdam, Department of Rehabilitation Medicine, Amsterdam Movement 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