{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T07:37:30Z","timestamp":1782286650597,"version":"3.54.5"},"reference-count":37,"publisher":"Mark Allen Group","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Wound Care"],"published-print":{"date-parts":[[2023,8,2]]},"abstract":"<jats:sec><jats:title>Objective:<\/jats:title><jats:p> To assess the demographic and clinical characteristics, laboratory findings, and economic burden of patients with a diagnosis of complicated skin and soft tissue infection (cSSTI). <\/jats:p><\/jats:sec><jats:sec><jats:title>Method:<\/jats:title><jats:p> The demographic and clinical characteristics, laboratory findings, surgical interventions, cost of treatment, and outcome of patients diagnosed with cSSTIs between January 2017 and December 2019 were retrospectively analysed. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> A total of 24 patients with cSSTIs were included in the study. The median age was 53 (22\u201385) years, and 14 (58%) were female. The most common comorbidity was diabetes (54%). On admission, 75% of patients presented with sepsis, and 70% had a high-grade Laboratory Risk Indicator for Necrotising Fasciitis (LRINEC) score. The causative microorganism was isolated from 21 (87%) patients, and the multidrug resistance rate of Gram-negative bacteria was 50%. The median number of debridements was 3 (1\u201312). In all, 11 patients were followed up in the intensive care unit, and the mortality rate was 29%. The presence of confusion (p=0.025), causative Gram-negative microorganisms (p=0.009), hyponatraemia (p=0.034), the need for intensive care (p=0.001), anti-meticillin-resistant Staphylococcus aureus antibiotics (p=0.023) and the rate of antibiotic changes during treatment (p=0.019) were significantly higher in the non-survival patient group. Hyponatraemia was a significant independent risk factor for mortality (p=0.048). The median cost of per-patient treatment was $9453 USD in the non-surviving and $1536 in the surviving group. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> It is important to know possible factors and local resistance rates at the beginning of empirical antibacterial and surgical treatment. The presence of hyponatraemia, sepsis and a high LRINEC score can be considered to be the mortality predictors. <\/jats:p><\/jats:sec>","DOI":"10.12968\/jowc.2023.32.8.492","type":"journal-article","created":{"date-parts":[[2023,8,12]],"date-time":"2023-08-12T17:18:36Z","timestamp":1691860716000},"page":"492-499","source":"Crossref","is-referenced-by-count":2,"title":["Severe and complicated soft tissue infections: a single-centre case series"],"prefix":"10.12968","volume":"32","author":[{"given":"Zeynep","family":"Ture","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Faculty of Medicine, Erciyes University, Kayseri, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gamze Kalin","family":"Unuvar","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Faculty of Medicine, Erciyes University, Kayseri, 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