{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T21:05:39Z","timestamp":1790024739014,"version":"4.0.1"},"reference-count":28,"publisher":"Mark Allen Group","issue":"Sup4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Wound Care"],"published-print":{"date-parts":[[2023,4,1]]},"abstract":"<jats:sec><jats:title>Objectives:<\/jats:title><jats:p>Diabetic foot ulcers (DFUs) cause high morbidity and mortality despite best treatment. Thus, new products are urgently needed to treat DFUs. Intralesional epidermal growth factor (EGF) (Heberprot-p) is considered to be an adjuvant therapy to standard of care (SOC) in DFUs. In the present study, the effect of Heberprot-p treatment on wound healing is compared to standard treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>The data of patients with DFUs were retrospectively analysed. The patients who had had DFUs of at least four weeks' duration and who had been treated in the wound clinic between January 2014 and 2017 were included in the study. The patients were divided into study and control groups. The study group consisted of patients in whom intralesional recombinant human EGF, Heberprot-p 75\u03bcg, was applied; the control group consisted of the remaining patients in whom EGF was not applied. The efficacy of Heberprot-p treatment in Wagner 2 and 3 DFUs were retrospectively investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>The study group (n=29 patients) who received Heberprot-p treatment was found to have shorter treatment times and higher rates of wound healing than the control group (n=22 patients). Although the amputation rate in the study group was less than the control group, the difference was not statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p>Heberprot-p therapy is a promising treatment in DFUs, which can be routinely used as an adjunct to standard care.<\/jats:p><\/jats:sec>","DOI":"10.12968\/jowc.2023.32.sup4.s14","type":"journal-article","created":{"date-parts":[[2023,4,8]],"date-time":"2023-04-08T17:38:45Z","timestamp":1680975525000},"page":"S14-S21","source":"Crossref","is-referenced-by-count":6,"title":["Intralesional epidermal growth factor therapy in recalcitrant diabetic foot ulcers"],"prefix":"10.12968","volume":"32","author":[{"given":"Emre","family":"\u00d6zker","sequence":"first","affiliation":[{"name":"Head of Cardiovascular Surgery Department Alt\u0131nba\u015f University, Faculty of Medicine, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5130","reference":[{"issue":"9498","key":"B1","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1016\/S0140-6736(05)67699-4","volume":"366","author":"Cavanagh PR","year":"2005","journal-title":"Lancet"},{"key":"B2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/562625","volume":"2014","author":"Dhall S","year":"2014","journal-title":"J Diabetes Res"},{"issue":"6","key":"B3","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1177\/193229681100500636","volume":"5","author":"Armstrong DG","year":"2011","journal-title":"J Diabetes Sci Technol"},{"issue":"9498","key":"B4","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1016\/S0140-6736(05)67698-2","volume":"366","author":"Boulton AJ","year":"2005","journal-title":"Lancet"},{"issue":"12","key":"B5","doi-asserted-by":"crossref","first-page":"e132","DOI":"10.1093\/cid\/cis346","volume":"54","author":"Lipsky BA","year":"2012","journal-title":"Clin Infect Dis"},{"issue":"6","key":"B6","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/s11892-003-0010-4","volume":"3","author":"Schaper NC","year":"2003","journal-title":"Curr Diab Rep"},{"issue":"5","key":"B7","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.3906\/sag-1703-153","volume":"47","author":"I\u015fikg\u00f6z Ta\u015fbakan M","year":"2017","journal-title":"Turk J Med Sci"},{"issue":"6","key":"B8","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1111\/j.1742-481X.2009.00641.x","volume":"6","author":"Fern\u00e1ndez-Montequ\u00edn JI","year":"2009","journal-title":"Int Wound J"},{"key":"B9","first-page":"2","volume":"2","author":"L\u00f3pez-Saura PA","year":"2013","journal-title":"Adv Pharmacoepidemiol Drug Saf"},{"issue":"1","key":"B10","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/2050-6511-14-44","volume":"14","author":"Yera-Alos IB","year":"2013","journal-title":"BMC Pharmacol Toxicol"},{"key":"B11","first-page":"21","volume":"14","author":"Garc\u00eda-Herrera AL","year":"2011","journal-title":"Spanish J Surgical Res"},{"issue":"5","key":"B12","doi-asserted-by":"crossref","first-page":"855","DOI":"10.2337\/diacare.21.5.855","volume":"21","author":"Armstrong DG","year":"1998","journal-title":"Diabetes Care"},{"issue":"1","key":"B13","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1111\/iwj.12592","volume":"14","author":"Ojalvo AG","year":"2017","journal-title":"Int Wound J"},{"issue":"3","key":"B14","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1586\/1744666X.2.3.403","volume":"2","author":"Thomson SE","year":"2006","journal-title":"Expert Rev Clin Immunol"},{"issue":"5","key":"B15","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1016\/S0021-9258(19)83739-0","volume":"237","author":"Cohen S.","year":"1962","journal-title":"J Biol Chem"},{"issue":"6","key":"B16","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.2337\/diacare.26.6.1856","volume":"26","author":"Tsang MW","year":"2003","journal-title":"Diabetes Care"},{"issue":"3","key":"B17","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1046\/j.1524-475x.2000.00192.x","volume":"8","author":"Gibbs S","year":"2000","journal-title":"Wound Repair Regen"},{"key":"B18","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.curtheres.2017.03.003","volume":"85","author":"Garcia Herrera AL","year":"2017","journal-title":"Curr Ther Res Clin Exp"},{"issue":"4","key":"B19","first-page":"33","volume":"24","author":"Montequin JF","year":"2018","journal-title":"Angiol Sosud Khir"},{"issue":"4","key":"B20","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1111\/j.1742-481X.2007.00344.x","volume":"4","author":"Fern\u00e1ndez-Montequ\u00edn JI","year":"2007","journal-title":"Int Wound J"},{"issue":"1","key":"B21","doi-asserted-by":"crossref","first-page":"17","DOI":"10.7547\/15-056","volume":"107","author":"Ertugrul BM","year":"2017","journal-title":"J Am Podiatr Med Assoc"},{"issue":"4","key":"B22","first-page":"233","volume":"24","author":"Blanes JI","year":"2011","journal-title":"Rev Esp Quimioter"},{"issue":"7","key":"B23","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.2337\/dc07-2145","volume":"31","author":"Ghanassia E","year":"2008","journal-title":"Diabetes Care"},{"key":"B24","first-page":"11","volume":"11","author":"Gonzales-Acosta S","year":"2011","journal-title":"Rev Cuba Angiol Cir Vasc"},{"issue":"6","key":"B25","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.jdiacomp.2007.09.004","volume":"21","author":"Winkley K","year":"2007","journal-title":"J Diabetes Complications"},{"key":"B26","first-page":"136","volume":"27","author":"Vel\u00e1zquez W","year":"2010","journal-title":"Biotecnol Apl"},{"issue":"3","key":"B27","first-page":"153","volume":"10","author":"Guillermo G","year":"2012","journal-title":"Rev Argentina Cirugia Cardiovasc"},{"issue":"1","key":"B28","first-page":"1","volume":"43","author":"Eggert JV","year":"2016","journal-title":"Undersea Hyperb Med"}],"container-title":["Journal of Wound Care"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/pdf\/10.12968\/jowc.2023.32.Sup4.S14","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,10]],"date-time":"2023-12-10T11:26:06Z","timestamp":1702207566000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/10.12968\/jowc.2023.32.Sup4.S14"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,1]]},"references-count":28,"journal-issue":{"issue":"Sup4","published-print":{"date-parts":[[2023,4,1]]}},"alternative-id":["10.12968\/jowc.2023.32.Sup4.S14"],"URL":"https:\/\/doi.org\/10.12968\/jowc.2023.32.sup4.s14","relation":{},"ISSN":["0969-0700","2052-2916"],"issn-type":[{"value":"0969-0700","type":"print"},{"value":"2052-2916","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,1]]}}}