{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T22:30:08Z","timestamp":1780353008199,"version":"3.54.1"},"reference-count":29,"publisher":"Mark Allen Group","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Wound Care"],"published-print":{"date-parts":[[2024,10,2]]},"abstract":"<jats:sec><jats:title>Objective:<\/jats:title><jats:p> This study examined the effectiveness of a combination of hyperbaric oxygen therapy (HBOT) and topical haemoglobin spray in treating hard-to-heal, sloughy diabetic foot ulcers (DFUs). <\/jats:p><\/jats:sec><jats:sec><jats:title>Method:<\/jats:title><jats:p> Patients with hard-to-heal DFUs at least 25% sloughy or necrotic were included in the study. We compared the results of patients who received standard of care and HBOT with topical haemoglobin spray (oxygen group) to an equal number of patients who only received standard personalised wound care (control group). The initial values of haemoglobin A1C and C-reactive protein, wound culture results and SINBAD (site, ischaemia, neuropathy, bacterial infection, area, depth) scores were documented. Wounds were considered healed when completely closed within 16 weeks. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> The oxygen group (n=21) had a mean SINBAD score of 5.00\u00b10.89, while the control group (n=21) had a mean score of 4.62\u00b10.80 (p=0.155). After 16 weeks, 85.7% of wounds in the oxygen group showed complete recovery, compared with 52.4% in the control group (p=0.02). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> In this study, a greater number of wounds in the oxygen group healed. Combining HBOT with topical haemoglobin spray provides oxygenation to the wound for longer, primarily because patients can receive 90 minutes of HBOT daily. This ensures that patients benefit from both systemic and local oxygen. This combination therapy may effectively address the problem of hypoxia and promote healing in hard-to-heal wounds. <\/jats:p><\/jats:sec>","DOI":"10.12968\/jowc.2024.0026","type":"journal-article","created":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T15:35:41Z","timestamp":1728574541000},"page":"796-802","source":"Crossref","is-referenced-by-count":2,"title":["Efficacy of combined hyperbaric oxygen therapy and topical haemoglobin spray in treating hard-to-heal sloughy wounds"],"prefix":"10.12968","volume":"33","author":[{"given":"Levent","family":"Demir","sequence":"first","affiliation":[{"name":"Department of Underwater and Hyperbaric Medicine, Kayseri City Training and Research Hospital, Kayseri, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5130","reference":[{"key":"B1","doi-asserted-by":"crossref","first-page":"100687","DOI":"10.1016\/j.mtbio.2023.100687","volume":"20","author":"He Y","year":"2023","journal-title":"Mater Today 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