{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T21:43:07Z","timestamp":1791495787150,"version":"4.3.4"},"reference-count":14,"publisher":"Mark Allen Group","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Wound Care"],"published-print":{"date-parts":[[2024,10,2]]},"abstract":"<jats:sec><jats:title>Objective:<\/jats:title><jats:p> Innovation in wound healing, particularly regarding diabetic foot ulcers (DFUs), is needed to reverse the number of diabetes-related amputations. This study evaluated a novel approach and performance of a multimodal wound matrix in converting stalled DFUs into a healing trajectory. <\/jats:p><\/jats:sec><jats:sec><jats:title>Method:<\/jats:title><jats:p> Patients with either type 1 or 2 diabetes and with foot ulcers (Wagner grade 1 and 2), were screened to determine eligibility for treatment. Ulcers improving &gt;30% in area during a two-week screening phase were not eligible for the study treatment phase. The study was an open-label trial conducted in three phases: screening, treatment and healing confirmation. Patients enrolled in the study received a treatment protocol that included application of a wound matrix to the ulcer and offloading. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> A total of 19 patients (15 males, four females) with a median age of 60 years, and a median ulcer duration of 36 weeks took part in the study. Patients showed an average four-week percentage area reduction (PAR) of 62%, a 12-week PAR of 94%, and a 12-week healing rate of 57% (8\/14). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> Results of this study support the viability and potential of a novel approach to treating DFUs that includes use of a multimodal wound matrix. <\/jats:p><\/jats:sec>","DOI":"10.12968\/jowc.2024.0085","type":"journal-article","created":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T14:01:56Z","timestamp":1725544916000},"page":"772-777","source":"Crossref","is-referenced-by-count":6,"title":["A novel approach for the treatment of diabetic foot ulcers using a multimodal wound matrix: a clinical study"],"prefix":"10.12968","volume":"33","author":[{"given":"Richard","family":"Simman","sequence":"first","affiliation":[{"name":"ProMedica Jobst Wound Care, Toledo, OH, US"},{"name":"Professor of Surgery, Plastic Surgery, University of Toledo College of Medicine, Toledo, OH, US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne J","family":"Bakewell","sequence":"additional","affiliation":[{"name":"Omeza, LLC, Sarasota, FL, US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Desmond","family":"Bell","sequence":"additional","affiliation":[{"name":"Omeza, LLC, Sarasota, FL, US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Shuman","sequence":"additional","affiliation":[{"name":"ProMedica Jobst Wound Care, Toledo, OH, US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Cheney","sequence":"additional","affiliation":[{"name":"ProMedica Jobst Wound Care, Toledo, OH, US"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5130","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.2337\/dci22-0043"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcot.2021.01.017"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2022.108317"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2015.0635"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2017.0743"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2023.32.Sup4b.S1"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2022.31.Sup2.S10"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1136\/bmjdrc-2020-001697"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1136\/bmjoq-2022-002206"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-023-02742-4"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.6.1879"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2008.02.001"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12395"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.25270\/wnds\/22094"}],"container-title":["Journal of Wound Care"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/pdf\/10.12968\/jowc.2024.0085","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T15:35:45Z","timestamp":1728574545000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/10.12968\/jowc.2024.0085"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,2]]},"references-count":14,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10,2]]}},"alternative-id":["10.12968\/jowc.2024.0085"],"URL":"https:\/\/doi.org\/10.12968\/jowc.2024.0085","relation":{},"ISSN":["0969-0700","2052-2916"],"issn-type":[{"value":"0969-0700","type":"print"},{"value":"2052-2916","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,2]]}}}