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While DFUs are not associated with immobility, they are associated with altered mobility occurring as a result of complications of diabetes. The incidence and prevalence of both types of lesions are increased in the presence of multimorbidity. The prediction of either type of ulceration is challenging. Current risk assessment practices are reported to be ineffective at predicting when ulceration will occur. While systemic inflammation is easily measured, the presence of local or subclinical inflammation is harder to discern. In patients at risk of either DFUs or PUs, clinical signs and symptoms of inflammation may be masked, and systemic biomarkers of inflammation may not be elevated sufficiently to predict imminent damage until ulceration appears. The current literature suggests that the use of local biomarkers of inflammation at the skin's surface, namely oedema and temperature, may identify early tissue damage. <\/jats:p>","DOI":"10.12968\/jowc.2024.0127","type":"journal-article","created":{"date-parts":[[2024,9,17]],"date-time":"2024-09-17T14:28:36Z","timestamp":1726583316000},"page":"630-635","source":"Crossref","is-referenced-by-count":6,"title":["Biomarkers of local inflammation at the skin's surface may predict both pressure and diabetic foot ulcers"],"prefix":"10.12968","volume":"33","author":[{"given":"Pauline","family":"Wilson","sequence":"first","affiliation":[{"name":"St. James's Hospital, Dublin, Ireland"},{"name":"Skin Wounds and Trauma Research Centre, Royal College of Surgeons in Ireland University of Medicine and Health Sciences, Dublin, Ireland"},{"name":"Health Service Executive, Dublin, 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