{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:00:29Z","timestamp":1792789229063,"version":"4.5.0"},"reference-count":52,"publisher":"Mark Allen Group","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Wound Care"],"published-print":{"date-parts":[[2024,10,2]]},"abstract":"<jats:sec><jats:title>Objective:<\/jats:title><jats:p> Delayed or stalled healing in open wounds can result from persisting chronic inflammation related to infection and\/or persistent bacterial colonisation and biofilm. Treatment of hard-to-heal wounds focuses on debridement and exudate management, but also on infection prevention and control. Silver dressings have been evaluated in randomised clinical trials (RCTs); this meta-analysis evaluated the efficacy and safety of a silver ion-releasing foam dressing (Biatain Ag; Coloplast A\/S, Denmark) to treat hard-to-heal wounds. <\/jats:p><\/jats:sec><jats:sec><jats:title>Method:<\/jats:title><jats:p> Literature databases (PubMed and Cochrane Library) were searched for studies on silver ion-releasing foam dressings in the treatment of hard-to-heal wounds. Individual patient data from four RCTs were obtained and included in the meta-analysis. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> Findings showed that treatment with the silver ion-releasing foam dressing was associated with a significantly higher relative reduction in wound area after four (least squares-mean difference (LS-MD): \u201312.55%, 95% confidence interval (CI): (\u201315.95, \u20139.16); p&lt;0.01) and six weeks of treatment (LS-MD: \u201311.94%, 95%CI: (\u201317.21, \u20136.68); p&lt;0.01) compared with controls. Significant benefits were also observed for time to disappearance of odour (hazard ratio: 1.61, 95%CI: (1.31, 1.98); p&lt;0.01), relative reduction of exudate (LS-MD: \u20135.15, 95%CI: (\u20137.36, \u20132.94); p&lt;0.01), proportion of patients with periwound erythema (relative risk (RR): 0.81, 95%CI: (0.69; 0.94); p&lt;0.01), and less pain at dressing removal (LS-MD: \u20130.35, 95%CI: (\u20130.63, \u20130.06); p=0.02). No differences regarding safety outcomes were identified. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> This meta-analysis has demonstrated beneficial outcomes and a good tolerability profile for silver ion-releasing foam dressings in the treatment of moderate-to-highly exuding wounds with delayed healing compared with control dressings. <\/jats:p><\/jats:sec>","DOI":"10.12968\/jowc.2024.0149","type":"journal-article","created":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T15:35:41Z","timestamp":1728574541000},"page":"726-736","source":"Crossref","is-referenced-by-count":8,"title":["Clinical efficacy and safety of a silver ion-releasing foam dressing on hard-to-heal wounds: a meta-analysis"],"prefix":"10.12968","volume":"33","author":[{"given":"Karl-Christian","family":"M\u00fcnter","sequence":"first","affiliation":[{"name":"Joint Dermatology Practice Bramfeld, Hamburg, 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