{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T20:40:45Z","timestamp":1727124045293},"reference-count":35,"publisher":"Mark Allen Group","issue":"Sup9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Wound Care"],"published-print":{"date-parts":[[2024,9,1]]},"abstract":"<jats:sec><jats:title>Objective:<\/jats:title><jats:p> While most xenograft wound matrices are flat sheets not designed for deep or tunnelling wounds, three-dimensional acellular collagen matrices (3D-ACM) can fill deep wound beds and enable full wound wall apposition. This case series examines the use of 3D-ACM in treating diabetic foot ulcers (DFUs) that are deep, tunnelling, undermining, or irregularly shaped. We report outcomes of cases where 3D-ACM was applied to deep or tunnelling DFUs present for at least four weeks. <\/jats:p><\/jats:sec><jats:sec><jats:title>Method:<\/jats:title><jats:p> In this retrospective case series, 3D-ACM was applied, healing was monitored and measurements were collected. Additional 3D-ACM was applied as needed. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> In total, 11 patients with 13 wounds were treated. Improved wound appearance and reduced size were observed at most follow-ups. Mean initial wound depth was 1.6cm, and several wounds showed significant depth reductions shortly after therapy initiation. In total, 62% of wounds (8\/13) reached 50% closure by four weeks. Additionally, 54% (7\/13) were fully closed by 12 weeks. The remaining 46% (6\/13) took between 12\u201322.3 weeks to heal. Overall mean therapy time was 13.1 weeks (range: 2.0\u201322.3 weeks). Deeper wounds generally took longer to close. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> The findings of this case series showed that 3D-ACM could offer a protective microenvironment for wound management for deep or tunnelling DFUs. While some took &gt;12 weeks to close, this may be attributable to large initial depths and volumes, rather than a failure to respond to the treatment modality. Other wounds that require a conforming 3D matrix, enabling full wound wall apposition, may benefit from 3D-ACM. Further investigations would be beneficial to understand the capabilities of this treatment modality. <\/jats:p><\/jats:sec>","DOI":"10.12968\/jowc.2024.0176","type":"journal-article","created":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T17:38:13Z","timestamp":1726508293000},"page":"S5-S16","source":"Crossref","is-referenced-by-count":0,"title":["Use of three-dimensional acellular collagen matrix in deep or tunnelling diabetic foot ulcers: a retrospective case series"],"prefix":"10.12968","volume":"33","author":[{"given":"Raymond J","family":"Abdo","sequence":"first","affiliation":[{"name":"Mercy Hospital South, St. Louis, Missouri, US"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy L","family":"Couch","sequence":"additional","affiliation":[{"name":"Mercy Hospital South, St. Louis, Missouri, 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