{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T11:57:56Z","timestamp":1791460676893,"version":"4.3.4"},"reference-count":40,"publisher":"Mark Allen Group","issue":"Sup10A","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Wound Care"],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"<jats:p>Diabetic foot ulcers (DFUs) affect many patients with uncontrolled diabetes and are associated with significant morbidity. Platelet-rich plasma (PRP) preparations have been validated as effective adjuncts in the treatment of DFUs. This narrative review seeks to appraise and critique literature related to PRP use for DFUs. As a result, the inconsistent reporting of statistical analyses and preparation procedures among studies are highlighted. In 2017, the Minimum Information for Studies Evaluating Biologics in Orthopaedics (MIBO) guideline was compiled to standardise the reporting of orthobiologic studies. Studies prior to 2017 would, understandably, not include adequate reporting of their preparation; however, some research after 2017 is still lacking thorough reporting of preparation procedures. Although some of the studies presented in this review demonstrate adequate adherence to guidelines, others exhibit a lack of reporting standards, specifically in terms of the preparation of PRP. In addition, the absence of comprehensive statistical analysis in the studies presented remains an issue, as it limits readers' ability to draw conclusions and compare results across a diverse set of studies. As PRP becomes more prevalent in the treatment of DFUs, there is an increased need for standardised preparation and reporting in investigational studies. There are existing guidelines for reporting, but these are not always followed in the literature. In future studies, an effort should be made to ensure consistent reporting.<\/jats:p>","DOI":"10.12968\/jowc.2024.0239","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T10:57:27Z","timestamp":1791457047000},"source":"Crossref","is-referenced-by-count":0,"title":["Platelet-rich plasma for managing diabetic foot ulcers and preparation procedure reporting: a narrative review"],"prefix":"10.12968","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-6585-7933","authenticated-orcid":false,"given":"William K","family":"Copenhaver","sequence":"first","affiliation":[{"name":"Futures Forward Research Institute, Toms River, NJ, US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan St.","family":"John","sequence":"additional","affiliation":[{"name":"Futures Forward Research Institute, Toms River, NJ, US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Rome","sequence":"additional","affiliation":[{"name":"Futures Forward Research Institute, Toms River, NJ, US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunal P","family":"Shah","sequence":"additional","affiliation":[{"name":"Futures Forward Research Institute, Toms River, NJ, US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasan","family":"Zia","sequence":"additional","affiliation":[{"name":"Lumina Institute, Cream Ridge, NJ, US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon","family":"Goodwin","sequence":"additional","affiliation":[{"name":"Futures Forward Research Institute, Toms River, NJ, US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilbert","family":"Siu","sequence":"additional","affiliation":[{"name":"Physical Medicine and Rehabilitation, Inspira Medical Center, Vineland, NJ US"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5130","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)02317-1"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1615243"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.10578"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtv.2025.100913"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.13569"},{"key":"e_1_3_2_6_2","unstructured":"Oliver TI Mutluoglu M. Diabetic foot ulcer. StatPearls Publishing. 2023. https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK537328 (accessed 2 June 2026)"},{"key":"e_1_3_2_7_2","unstructured":"Hanley ME Manna B. Hyperbaric treatment of diabetic foot ulcer. StatPearls Publishing. 2026. https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK430783 (accessed 2 June 2026)"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1080\/09537104.2018.1430357"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.25270\/wnds\/2021.219221"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.04.037"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2021.01.030"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1256081"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546510387517"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-08-2804"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.K.00430"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546517740845"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1054\/jcms.2002.0285"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2013.141"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.16.00793"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.5435\/JAAOS-D-18-00305"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/rapm-2018-100356"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/630870"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2016.10.020"},{"issue":"4","key":"e_1_3_2_24_2","first-page":"36","article-title":"A retrospective, longitudinal study to evaluate healing lower extremity wounds in patients with diabetes mellitus and ischemia using standard protocols of care and platelet-rich plasma gel in a Japanese wound care program","volume":"58","author":"Sakata J","year":"2012","unstructured":"Sakata J, Sasaki S, Handa K et al. A retrospective, longitudinal study to evaluate healing lower extremity wounds in patients with diabetes mellitus and ischemia using standard protocols of care and platelet-rich plasma gel in a Japanese wound care program. Ostomy Wound Manage 2012; 58(4):36\u201349","journal-title":"Ostomy Wound Manage"},{"issue":"6","key":"e_1_3_2_25_2","first-page":"68","article-title":"A prospective, randomized, controlled trial of autologous platelet-rich plasma gel for the treatment of diabetic foot ulcers","volume":"52","author":"Driver VR","year":"2006","unstructured":"Driver VR, Hanft J, Fylling CP, Beriou JM; Autologel Diabetic Foot Ulcer Study Group. A prospective, randomized, controlled trial of autologous platelet-rich plasma gel for the treatment of diabetic foot ulcers. Ostomy Wound Manage 2006; 52(6):68\u201370","journal-title":"Ostomy Wound Manage"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-481X.2011.00797.x"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.5114\/pdia.2016.62415"},{"issue":"6","key":"e_1_3_2_28_2","first-page":"36","article-title":"Chronic wounds treated with a physiologically relevant concentration of platelet-rich plasma gel: a prospective case series","volume":"56","author":"Frykberg RG","year":"2010","unstructured":"Frykberg RG, Driver VR, Carman D et al. Chronic wounds treated with a physiologically relevant concentration of platelet-rich plasma gel: a prospective case series. Ostomy Wound Manage 2010; 56(6):36\u201344","journal-title":"Ostomy Wound Manage"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-019-05316-0"},{"issue":"9","key":"e_1_3_2_30_2","first-page":"13796","article-title":"Autologous platelet-rich gel for lower-extremity ischemic ulcers in patients with type 2 diabetes","volume":"10","author":"Yang L","year":"2017","unstructured":"Yang L, Gao L, Lang LV, Wang J. Autologous platelet-rich gel for lower-extremity ischemic ulcers in patients with type 2 diabetes. Int J Clin Exp Med 2017; 10(9):13796\u201313801","journal-title":"Int J Clin Exp Med"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2019.09.069"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.17795\/nmsjournal30314"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2017.26.12.784"},{"issue":"4","key":"e_1_3_2_34_2","first-page":"849","article-title":"A comparative study on effect of platelet rich plasma vs conventional dressing in healing rate of chronic diabetic ulcers","volume":"41","author":"Rajendran S","year":"2021","unstructured":"Rajendran S, Thiyagarajan M, Singh B, Navrathan N. A comparative study on effect of platelet rich plasma vs conventional dressing in healing rate of chronic diabetic ulcers. Biomedicine (Taipei) 2021; 41(4):849\u2013854","journal-title":"Biomedicine (Taipei)"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.5455\/njppp.2022.12.00135202219012022"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASW.0000577140.19174.9e"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1177\/0963689720931428"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-017-0324-1"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASW.0000403249.85131.6f"},{"issue":"2","key":"e_1_3_2_40_2","first-page":"46","article-title":"A case series of autologous platelet-rich plasma injection in treating chronic ulcers conducted in Saudi Arabia","volume":"17","author":"Tabanjeh SF","year":"2023","unstructured":"Tabanjeh SF, Al-Malki T, Kharabsheh RA, Mahmood D. A case series of autologous platelet-rich plasma injection in treating chronic ulcers conducted in Saudi Arabia. Int J Health Sci (Qassim) 2023; 17(2):46\u201356","journal-title":"Int J Health Sci (Qassim)"}],"container-title":["Journal of Wound Care"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/pdf\/10.12968\/jowc.2024.0239","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T11:31:23Z","timestamp":1791459083000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/10.12968\/jowc.2024.0239"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,1]]},"references-count":40,"journal-issue":{"issue":"Sup10A","published-print":{"date-parts":[[2026,10,1]]}},"alternative-id":["10.12968\/jowc.2024.0239"],"URL":"https:\/\/doi.org\/10.12968\/jowc.2024.0239","relation":{},"ISSN":["0969-0700","2052-2916"],"issn-type":[{"value":"0969-0700","type":"print"},{"value":"2052-2916","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,1]]}}}