{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T02:38:59Z","timestamp":1755225539478,"version":"3.43.0"},"reference-count":36,"publisher":"Mark Allen Group","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Wound Care"],"published-print":{"date-parts":[[2025,8,2]]},"abstract":"<jats:sec><jats:title>Objective:<\/jats:title><jats:p> Pain in patients with leg ulcers is common and there is a need for effective treatments. The analgesic effects of botulinum neurotoxin A (BTX-A) have been well-documented and this exploratory study primarily investigated its analgesic effect in patients with leg ulcers. <\/jats:p><\/jats:sec><jats:sec><jats:title>Method:<\/jats:title><jats:p> In this prospective, investigator-initiated, open-label, clinical trial, patients with leg and foot ulcers dominated by neuropathic wound pain were enrolled consecutively and treated with perilesional injections of BTX-A on day 0 (D0). The patients were followed-up on D21, D60 and D90. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> A total of 10 patients with leg and foot ulcers were enrolled in this study (\u226530mm on a visual analogue scale (VAS) for pain from 0\u2014100mm)\u2014seven with venous leg ulcers and three with inflammatory ulcers. After starting treatment with BTX-A, pain was reduced by \u226520mm on the VAS at D21 (pre-defined endpoint) in seven (70%) patients (p&lt;0.05). Neuropathic pain scores (Douleur Neuropathique 4 questionnaire) were significantly (p&lt;0.05) reduced at all follow-up visits, while wellbeing scores (World Health Organization-5) increased significantly (p&lt;0.05) after BTX-A injection. Percentage reduction of wound area was significant from D60 onwards. The wound fluid levels of interleukin-1\u03b2 and the neuropeptide calcitonin gene-related peptide resembled the wound healing course. BTX-A was well-tolerated with no drug-related severe adverse events. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> The findings of this study demonstrated that BTX-A holds potential for wound pain management and justify the need for more rigorous clinical investigations. <\/jats:p><\/jats:sec>","DOI":"10.12968\/jowc.2024.0285","type":"journal-article","created":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T13:38:13Z","timestamp":1726493893000},"page":"608-615","source":"Crossref","is-referenced-by-count":0,"title":["Botulinum neurotoxin A for treatment of pain in lower extremity ulcers: an exploratory study"],"prefix":"10.12968","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0899-6881","authenticated-orcid":false,"given":"Lubna","family":"Sabah","sequence":"first","affiliation":[{"name":"Department of Dermato-Venereology and Copenhagen Wound Healing Center, Bispebjerg Hospital, University of Copenhagen, 2400 Copenhagen, 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