{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T17:55:46Z","timestamp":1781891746789,"version":"3.54.5"},"reference-count":34,"publisher":"Mark Allen Group","issue":"Sup6b","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Wound Care"],"published-print":{"date-parts":[[2026,6,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Hard-to-heal (chronic) diabetic foot ulcers (DFUs) are a major healthcare challenge worldwide. A combinatorial strategy may offer effective therapeutic potential. The present study investigated the effectiveness of a repairing gel containing platelet-rich plasma-fibrin glue (PRP-FG) and oral methylene blue (MB, administered as leucomethylene blue (LMB)) for hard-to-heal DFUs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method:<\/jats:title>\n                    <jats:p>This single-centre, self-controlled pilot study was conducted on patients with DFUs who met the inclusion criteria. All patients had not responded to standard therapies for at least four weeks. For 12 weeks, they received the repairing gel dressing and 35mg of MB dissolved in 200ml of infant formula milk (administered as LMB). Participants had weekly follow-up visits to assess their wound healing progress.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of six patients took part; four participants completed the 12 weeks of treatment. At the end of the treatment period, the new intervention was compared to previous standard care. Participants demonstrated a reduced wound area and improved wound bed condition. A significant increase in transcutaneous oxygen tension was observed, indicating improved tissue oxygenation (p=0.034). Additionally, participants experienced reductions in wound exudate, pain and malodour within the first week of treatment. No serious adverse events were reported during the follow-up period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The findings of this pilot study suggest that combined therapy using a PRP-FG-containing repair gel and oral MB (as LMB) may provide a safe and effective approach to treating hard-to-heal DFUs. Further research is warranted to confirm these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.12968\/jowc.2024.0387","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T17:00:47Z","timestamp":1781024447000},"source":"Crossref","is-referenced-by-count":0,"title":["Platelet-rich-fibrin repairing gel plus oral methylene blue for hard-to-heal diabetic foot ulcers: a pilot study"],"prefix":"10.12968","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8763-6890","authenticated-orcid":false,"given":"Elaheh","family":"Emadi","sequence":"first","affiliation":[{"name":"Cellular and Molecular Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran"},{"name":"Vascular and Endovascular Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Mousavian","sequence":"additional","affiliation":[{"name":"Vascular and Endovascular Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran"},{"name":"Orthopedic Research Center, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad-Hadi","family":"Saeed Modaghegh","sequence":"additional","affiliation":[{"name":"Vascular and Endovascular Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daryoush Hamidi","family":"Alamdari","sequence":"additional","affiliation":[{"name":"Vascular and Endovascular Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran"},{"name":"Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5130","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.10578"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/1753-0407.13372"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.2337\/dci22-0043"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/burnst\/tkae012"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/1359537"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1286907"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2024.0065"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/1753-0407.13537"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.12701\/jyms.2023.00682"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.47391\/JPMA.6634%20"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v13.i12.1014"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics16060750"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.2174\/0929867331666230911113159"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-02419-3"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1080\/13880209.2023.2254341"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2022.103016"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.33533\/jpm.v16i2.4792"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.33235\/wpr.30.3.163-168"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12753"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1139\/cjpp-2018-0119"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40267-023-01044-7"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1080\/14712598.2021.1897100"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.21089\/njhs.81.0028"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S433033"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2023.32.12.773"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.43452"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1177\/20417314231190288"},{"key":"e_1_3_2_28_2","first-page":"443","article-title":"The effect of adding platelet-rich plasma to fibrin glue on release of platelet growth factors and its stability","volume":"28","author":"Santiwatana S","year":"2018","unstructured":"Santiwatana S, Sasanakul W, Kadegasem P, Chuansumrit A. 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