{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T07:44:58Z","timestamp":1793259898725,"version":"4.5.0"},"reference-count":21,"publisher":"Mark Allen Group","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Wound Care"],"published-print":{"date-parts":[[2025,7,2]]},"abstract":"<jats:sec><jats:title>Objective:<\/jats:title><jats:p> To explore the potential cost-effectiveness of using a nitric oxide-generating medical device (EDX110, ConvaNiox, Convatec Ltd., UK) in the management of hard-to-heal diabetic foot ulcers (DFUs) among patients with type 1 or 2 diabetes, from the perspective of the UK's health services. <\/jats:p><\/jats:sec><jats:sec><jats:title>Method:<\/jats:title><jats:p> Markov modelling simulated the management of infected and non-infected hard-to-heal (chronic) DFUs with EDX110 or standard care in the community and secondary care over a 24-week period. The model was constructed using data from a previous randomised controlled trial and was used to estimate the potential cost-effectiveness of EDX110 in terms of the incremental cost per quality-adjusted life year (QALY) gained at 2021\/22 prices. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> There was a 63% improvement in healing by 24 weeks in the EDX110 group compared with standard care (49% versus 30%, respectively). This led to a 6% improvement in health-related quality of life and a 20% reduction in the total cost of DFU management. At a purchase price of \u00a340 per EDX110 dressing, it was found to afford a cost-effective treatment in &gt;80% of a cohort. However, the location where the dressing is administered (i.e., the community or secondary care) can potentially influence EDX110's cost-effectiveness. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> Within the limitations of the study, EDX110 could potentially afford the UK's health services a cost-effective treatment for DFUs; however, this is dependent on the location of the healthcare professionals administering the dressing. <\/jats:p><\/jats:sec>","DOI":"10.12968\/jowc.2024.0417","type":"journal-article","created":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T14:25:22Z","timestamp":1752071122000},"page":"476-486","source":"Crossref","is-referenced-by-count":1,"title":["Cost-effectiveness of a nitric oxide-generating medical device in managing hard-to-heal diabetic foot ulcers"],"prefix":"10.12968","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0162-2007","authenticated-orcid":false,"given":"Julian 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