{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T19:14:39Z","timestamp":1776539679343,"version":"3.51.2"},"reference-count":22,"publisher":"Mark Allen Group","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Wound Care"],"published-print":{"date-parts":[[2024,1,2]]},"abstract":"<jats:sec><jats:title>Objective:<\/jats:title><jats:p> To estimate whether the topical, amino acid-buffered hypochlorite debriding gel ChloraSolv (RLS Global AB, Sweden) could potentially afford the UK's health services a cost-effective intervention for hard-to-heal venous leg ulcers (VLUs). <\/jats:p><\/jats:sec><jats:sec><jats:title>Method:<\/jats:title><jats:p> A Markov model representing the management of hard-to-heal VLUs with ChloraSolv plus standard care (SC) or SC alone was populated with inputs from an indirect comparison of two propensity score-matched cohorts. The model estimated the relative cost-effectiveness of ChloraSolv in terms of the incremental cost per quality-adjusted life year (QALY) gained at 2021\/2022 prices. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> Addition of ChloraSolv to an SC protocol was found to increase the probability of healing by 36% (from 0.14 to 0.19) after 12 weeks, and by 79% (from 0.24 to 0.43) after 24 weeks. This led to a marginal increase in health-related quality of life. Treatment with ChloraSolv plus SC instead of SC alone reduced the total cost of wound management by 8% (\u00a3189 per VLU) at 12 weeks and by 18% (\u00a3796 per VLU) at 24 weeks. Use of ChloraSolv was estimated to improve health outcomes at reduced cost. Sensitivity analysis showed that use of ChloraSolv plus SC remained a cost-effective treatment with plausible variations in costs and effectiveness. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> Within the limitations of the study, the addition of ChloraSolv to an SC protocol potentially affords a cost-effective treatment to the UK's health services for managing hard-to-heal VLUs. <\/jats:p><\/jats:sec>","DOI":"10.12968\/jowc.2024.33.1.4","type":"journal-article","created":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T10:18:27Z","timestamp":1704881907000},"page":"4-13","source":"Crossref","is-referenced-by-count":2,"title":["Cost-effectiveness of ChloraSolv in treating hard-to-heal venous leg ulcers"],"prefix":"10.12968","volume":"33","author":[{"given":"Julian F","family":"Guest","sequence":"first","affiliation":[{"name":"Catalyst Consultants, Poole, 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