{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T23:15:33Z","timestamp":1785798933680,"version":"3.56.0"},"reference-count":14,"publisher":"Mark Allen Group","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Wound Care"],"published-print":{"date-parts":[[2024,2,2]]},"abstract":"<jats:sec><jats:title>Objective:<\/jats:title><jats:p> Excessive numbers of bacteria in hard-to-heal wounds impede wound healing. Numerous topical antiseptics have demonstrated effectiveness in benchtop studies; however, few clinical studies have demonstrated efficacy in the target population: patients with hard-to-heal wounds. This study addressed the clinical efficacy of a novel antibiofilm cleanser and gel in reducing bacterial load and improving wound outcomes. <\/jats:p><\/jats:sec><jats:sec><jats:title>Method:<\/jats:title><jats:p> Hard-to-heal wounds were photographed, measured and evaluated for bacterial load using fluorescence imaging weekly for four weeks. The target ulcers were randomised to be cleaned and treated with either a synergistic antibiofilm cleanser and antibiofilm gel with standard of care (AMC-AMG + SoC) or normal saline wash and an amorphous gel with standard of care (NSS-HG + SoC). <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> A Chi-squared test of independence determined that the relationship between the treatment and the patient reaching 40% percentage area reduction (PAR) in four weeks was not significant (\u03c7<jats:sup>2<\/jats:sup>(1, n=54)=0.73; p=0.39 at a significance level of 0.05); however, there was a strong trend favouring the antibiofilm cleanser and gel. A significant reduction (p&lt;0.05) in bacterial load was observed in the antibiofilm group. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> This randomised controlled double-blind proof-of-concept study suggests that the performance of antibiofilm agents in vivo is comparable to that in vitro studies. <\/jats:p><\/jats:sec>","DOI":"10.12968\/jowc.2024.33.2.84","type":"journal-article","created":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T17:02:51Z","timestamp":1707411771000},"page":"84-89","source":"Crossref","is-referenced-by-count":2,"title":["A double-blind trial comparing an antimicrobial combination to standard care in hard-to-heal wounds"],"prefix":"10.12968","volume":"33","author":[{"given":"Maha","family":"Khan","sequence":"first","affiliation":[{"name":"Texas Christian University, Anne Marie Burnett School of Medicine, Fort Worth, TX, US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"King","sequence":"additional","affiliation":[{"name":"SerenaGroup Research, US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristy","family":"Breisinger","sequence":"additional","affiliation":[{"name":"SerenaGroup Research, US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Serena","sequence":"additional","affiliation":[{"name":"SerenaGroup Research, US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas E","family":"Serena","sequence":"additional","affiliation":[{"name":"SerenaGroup Research, US"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5130","reference":[{"issue":"4","key":"B2","doi-asserted-by":"crossref","first-page":"145","DOI":"10.12968\/jowc.2008.17.4.28835","volume":"17","author":"Wolcott RD","year":"2008","journal-title":"J Wound Care"},{"issue":"1","key":"B3","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.4103\/2321-3868.113329","volume":"1","author":"Metcalf DG","year":"2013","journal-title":"Burns Trauma"},{"key":"B4","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.12968\/jowc.2022.31.LatAm_sup_5.33","volume":"31","author":"Murphy C","year":"2022","journal-title":"J Wound Care"},{"issue":"3","key":"B5","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1089\/wound.2020.1272","volume":"10","author":"Le L","year":"2021","journal-title":"Adv Wound Care"},{"issue":"1","key":"B6","doi-asserted-by":"crossref","first-page":"20","DOI":"10.12968\/jowc.2017.26.1.20","volume":"26","author":"Malone M","year":"2017","journal-title":"J Wound Care"},{"issue":"8","key":"B7","doi-asserted-by":"crossref","first-page":"366","DOI":"10.12968\/jowc.2015.24.8.366","volume":"24","author":"Wolcott R.","year":"2015","journal-title":"J Wound Care"},{"issue":"11","key":"B8","doi-asserted-by":"crossref","first-page":"31","DOI":"10.25270\/wmp.2020.11.3142","volume":"66","author":"McMahon R","year":"2020","journal-title":"Wound Manag Prev"},{"key":"B9","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1046\/j.1524-475X.11.s2.1.x","volume":"11","author":"Schultz GS","year":"2003","journal-title":"Wound Repair Regen"},{"issue":"3","key":"B10","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1089\/wound.2011.0333","volume":"1","author":"Attinger C","year":"2012","journal-title":"Adv Wound Care"},{"issue":"6","key":"B11","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1111\/j.1524-475X.2006.00174.x","volume":"14","author":"Robson MC","year":"2006","journal-title":"Wound Repair Regen"},{"issue":"5","key":"B12","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1111\/wrr.12590","volume":"25","author":"Schultz G","year":"2017","journal-title":"Wound Repair Regen"},{"issue":"8","key":"B13","doi-asserted-by":"crossref","first-page":"320","DOI":"10.12968\/jowc.2010.19.8.77709","volume":"19","author":"Wolcott RD","year":"2010","journal-title":"J Wound Care"},{"issue":"1","key":"B14","doi-asserted-by":"crossref","first-page":"9","DOI":"10.12968\/jowc.2021.30.1.9","volume":"30","author":"Serena TE","year":"2021","journal-title":"J Wound Care"},{"issue":"6","key":"B15","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.2337\/diacare.26.6.1696","volume":"26","author":"Margolis DJ","year":"2003","journal-title":"Diabetes Care"}],"container-title":["Journal of Wound Care"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/pdf\/10.12968\/jowc.2024.33.2.84","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T17:06:47Z","timestamp":1707412007000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/10.12968\/jowc.2024.33.2.84"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,2]]},"references-count":14,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2,2]]}},"alternative-id":["10.12968\/jowc.2024.33.2.84"],"URL":"https:\/\/doi.org\/10.12968\/jowc.2024.33.2.84","relation":{},"ISSN":["0969-0700","2052-2916"],"issn-type":[{"value":"0969-0700","type":"print"},{"value":"2052-2916","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,2]]}}}