{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T17:04:43Z","timestamp":1792343083213,"version":"4.4.0"},"reference-count":35,"publisher":"Mark Allen Group","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Wound Care"],"published-print":{"date-parts":[[2024,5,2]]},"abstract":"<jats:sec><jats:title>Objective:<\/jats:title><jats:p> To evaluate the efficacy of treatment of hard-to-heal wounds of patients with ischaemia of the lower extremities, and compare an omega-3 wound matrix product (Kerecis, Iceland) with a standard dressing. <\/jats:p><\/jats:sec><jats:sec><jats:title>Method:<\/jats:title><jats:p> A single-centre, prospective, randomised, controlled clinical trial of patients with hard-to-heal wounds following three weeks of standard care was undertaken. The ischaemic condition of the wound was confirmed as a decreased transcutaneous oxygen pressure (TcPO<jats:sub>2<\/jats:sub>) of &lt;40mmHg. After randomising patients into either a case (omega-3 dressing) or a control group (standard dressing), the weekly decrease in wound area over 12 weeks and the number of patients that achieved complete wound closure were compared between the two groups. Patients with a TcPO<jats:sub>2<\/jats:sub> of \u226432mmHg were taken for further analysis of their wound in a severe ischaemic context. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> A total of 28 patients were assigned to the case group and 22 patients to the control group. Over the course of 12 weeks, the wound area decreased more rapidly in the case group than the control group. Complete wound healing occurred in 82% of patients in the case group and 45% in the control group. Even in patients with a severe ischaemic wound with a TcPO<jats:sub>2<\/jats:sub> value of &lt;32 mmHg, wound area decreased more rapidly in the case group than the control group. The proportions of re-epithelialised area in the case and control groups were 80.24% and 57.44%, respectively. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> Considering the more rapid decrease in wound area and complete healing ratio in the case group, application of a fish skin-derived matrix for treating lower-extremity hard-to-heal wounds, especially with impaired vascularity, would appear to be a good treatment option. <\/jats:p><\/jats:sec>","DOI":"10.12968\/jowc.2024.33.5.348","type":"journal-article","created":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T17:31:07Z","timestamp":1714411867000},"page":"348-356","source":"Crossref","is-referenced-by-count":6,"title":["Treatment of hard-to-heal wounds in ischaemic lower extremities with a novel fish skin-derived matrix"],"prefix":"10.12968","volume":"33","author":[{"given":"Yeon Ji","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, St. Vincent Hospital, The Catholic University of Korea, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye Ju","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, St. Vincent Hospital, The Catholic University of Korea, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyung Sup","family":"Shim","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, St. Vincent Hospital, The Catholic University of Korea, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5130","reference":[{"key":"B1","doi-asserted-by":"crossref","first-page":"35S","DOI":"10.1097\/01.prs.0000225431.63010.1b","volume":"117","author":"Mustoe TA","year":"2006","journal-title":"Plast Reconstr Surg"},{"issue":"2","key":"B2","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1111\/iwj.13077","volume":"16","author":"Ahmaj\u00e4rvi KM","year":"2019","journal-title":"Int Wound J"},{"key":"B3","first-page":"e19","volume":"9","author":"Werdin F","year":"2009","journal-title":"Eplasty"},{"issue":"9","key":"B4","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1089\/wound.2015.0635","volume":"4","author":"Frykberg RG","year":"2015","journal-title":"Adv Wound Care"},{"key":"B5","doi-asserted-by":"crossref","unstructured":"Greer N, Foman N, Dorrian J et al. 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