{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T01:17:27Z","timestamp":1707873447478},"reference-count":26,"publisher":"Mark Allen Group","issue":"Sup2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Wound Care"],"published-print":{"date-parts":[[2024,2,1]]},"abstract":"<jats:sec><jats:title>Objective:<\/jats:title><jats:p> Approximately 13% of people living with diabetes develop one or more ulcers during the course of the disease, and diabetic foot ulcer (DFU) is responsible for &gt;60% of lower limb amputations worldwide. This case series aimed to demonstrate the effectiveness of medical-grade maggots on DFUs in promoting wound healing and reducing related hospital stays in northern Nigeria. <\/jats:p><\/jats:sec><jats:sec><jats:title>Method:<\/jats:title><jats:p> Maggot debridement therapy (MDT) was applied to the DFUs of patients who consented to this treatment between January\u2013August 2021 at the Orthopaedic Unit of the Aminu Kano Teaching Hospital (AKTH), Kano, Nigeria. Sterile first instar larvae of Lucilia sericata were obtained indigenously and applied using the confinement (free-range) method under aseptic procedure. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> A total of 15 patients with DFUs of Wagner classification grades III (33.3%) and IV (66.7%), were seen and documented. The patients included 10 (66.7%) females and five (33.3%) males, giving a female:male ratio of 2:1. The mean age (\u00b1standard deviation) of the respondents was 51.6\u00b110.8 years. The surface area of the wounds ranged from 24\u2013140cm<jats:sup>2<\/jats:sup>, with a median value of 75cm<jats:sup>2<\/jats:sup>. Among the patients, 60% had two cycles of MDT, with a median duration of five days. Most of the wounds (53.3%) were debrided within five days; 13.3% (two wounds) took seven days to be fully debrided. A paired sample t-test showed a statistically significant association between wound surface area and therapy duration (t=8.0; p=0.000) and between wound surface area and cycles of therapy (t=8.3; p=0.000). Before maggot application, 14 (93.3%) DFUs were completely (100%) covered with slough and only one (6.7%) was 95% covered with slough. After maggot application, 10 (66.7%) wounds were completely debrided while five (33.3%) wounds required bedside surgical debridement to achieve complete debridement. A paired sample t-test showed statistically significant difference between the pre- and post-MDT slough covering the wounds (t=45.1; p=0.000). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> In this case series, MDT was successfully used in the debridement of DFUs, which facilitated the healing process with an encouraging clinical outcome. <\/jats:p><\/jats:sec>","DOI":"10.12968\/jowc.2024.33.sup2.s24","type":"journal-article","created":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T11:28:10Z","timestamp":1707823690000},"page":"S24-S30","source":"Crossref","is-referenced-by-count":0,"title":["The role of medical-grade maggots in facilitating healing of diabetic foot ulcers in Kano, northern Nigeria: a case series"],"prefix":"10.12968","volume":"33","author":[{"given":"Mustapha Ahmed","family":"Yusuf","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology and Parasitology, Bayero University, Kano, 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University\/Aminu Kano Teaching Hospital, Kano, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bakare Ajibola","family":"Ridwan","sequence":"additional","affiliation":[{"name":"Department of Surgery, Bayero University\/Aminu Kano Teaching Hospital, Kano, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew E","family":"Uloko","sequence":"additional","affiliation":[{"name":"Department of Medicine, Bayero University\/Aminu Kano Teaching Hospital, Kano, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim D","family":"Gezawa","sequence":"additional","affiliation":[{"name":"Department of Medicine, Bayero University\/Aminu Kano Teaching Hospital, Kano, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mansur","family":"Ramalan","sequence":"additional","affiliation":[{"name":"Department of Medicine, Bayero University\/Aminu Kano Teaching Hospital, Kano, 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