{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T13:56:43Z","timestamp":1752674203504,"version":"3.41.2"},"reference-count":40,"publisher":"Mark Allen Group","issue":"Sup7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Wound Care"],"published-print":{"date-parts":[[2025,7,1]]},"abstract":"<jats:sec><jats:title>Objective:<\/jats:title><jats:p> Solomon Islands, a Western Pacific nation, faces a growing burden of type II diabetes amid chronic healthcare shortages. Surgeons report increased incidence of diabetic amputations; however, data on infection rates and pathology remain scarce. This study describes the microbiology of diabetic ulcers in cases of major limb amputation. <\/jats:p><\/jats:sec><jats:sec><jats:title>Method:<\/jats:title><jats:p> Demographic, microbiological and outcome data were extracted from records of patients with diabetes who underwent major limb amputation from 2018\u20132023 in Solomon Islands. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> Among 356 adults who underwent major limb amputation, microbiological data were available for 113 (32%). Pus and tissue cultures identified 20 bacterial species\u2014predominantly Pseudomonas aeruginosa (n=27; 24%), mixed enteric organisms (n=25; 23%) and Klebsiella pneumoniae (n=18; 16%). Meticillin-resistant Staphylococcus aureus was identified in one patient. Antibiotic resistance was observed in 62 (55%) cultures, with the highest resistance rates against: ampicillin (31 cases); amoxicillin (31 cases); gentamicin (21 cases); and trimethoprim\/sulfamethoxazole (21 cases). Escherichia coli, Klebsiella pneumoniae and Enterococcus spp. were significantly associated with resistance. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> The bacterial diversity and high resistance rates identified in this study are concerning given limited access to next-generation antibiotics in Solomon Islands. Further research is needed to evaluate infection management, resistance drivers and clinical outcomes of antibiotic-resistant infections in Solomon Islands. <\/jats:p><\/jats:sec>","DOI":"10.12968\/jowc.2025.0201","type":"journal-article","created":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T17:37:22Z","timestamp":1752082642000},"page":"S13-S22","source":"Crossref","is-referenced-by-count":1,"title":["Bacteriological profiles of diabetic ulcers in cases of major limb amputation: insights from Solomon Islands"],"prefix":"10.12968","volume":"34","author":[{"given":"Maguire E","family":"Anuszewski","sequence":"first","affiliation":[{"name":"Division of Biology and Medicine, Warren Alpert Medical School of Brown University, Providence, Rhode Island, US"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8595-7367","authenticated-orcid":false,"given":"Dylan M","family":"Bush","sequence":"additional","affiliation":[{"name":"Division of Biology and Medicine, Warren Alpert Medical School of Brown University, Providence, Rhode Island, US"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian Garcia","family":"Hernandez","sequence":"additional","affiliation":[{"name":"School of Engineering, Columbia University, New York, NY, US"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugo","family":"Bugoro","sequence":"additional","affiliation":[{"name":"Solomon Islands National University, Honiara, Solomon Islands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rooney","family":"Jagilly","sequence":"additional","affiliation":[{"name":"National Referral Hospital, Solomon Islands Ministry of Health & Medical Services, Honiara, Capital Territory, Solomon Islands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Micky","family":"Olangi","sequence":"additional","affiliation":[{"name":"Kilu'ufi Hospital, Solomon Islands Ministry of Health & Medical Services, Auki, Malaita Province, Solomon Islands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas H","family":"Fitzpatrick","sequence":"additional","affiliation":[{"name":"World Health Organization Representative Office for the Solomon Islands, Honiara, Capital Territory, Solomon Islands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Buin","sequence":"additional","affiliation":[{"name":"Gizo Hospital, Solomon Islands Ministry of Health & Medical Services, Gizo, Western Province, Solomon Island"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stallone","family":"Kohia","sequence":"additional","affiliation":[{"name":"National Referral Hospital, Solomon Islands Ministry of Health & Medical Services, Honiara, Capital Territory, Solomon Islands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Love","sequence":"additional","affiliation":[{"name":"Griffith University International WaterCentre: Nathan, QLD, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra L","family":"Martiniuk","sequence":"additional","affiliation":[{"name":"The George Institute for Global Health, Sydney Medical School, The University of Sydney, New South Wales, Australia"},{"name":"Dalla Lana School of Public Health, The University of Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5130","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.4103\/2468-8827.184853"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(16)30081-X"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)02317-1"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115734"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-022-00690-7"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.2522\/ptj.20080020"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.13.5.513"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.5312\/wjo.v6.i1.62"},{"key":"B11","unstructured":"Bodman MA, Dreyer MA, Varacallo MA. 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