{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T23:44:52Z","timestamp":1789429492258,"version":"build-2803163510"},"reference-count":43,"publisher":"Mark Allen Group","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Wound Care"],"published-print":{"date-parts":[[2025,11,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The aim of this clinical trial was to evaluate the performance and local tolerance of an innovative mesh-free contact layer (healing matrix) made of lipidocolloid technology (TLC) in the management of various wounds. This dressing is made highly flexible by the absence of textile mesh in its core.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method:<\/jats:title>\n                    <jats:p>A four-week, prospective, multicentre clinical trial was conducted on the evaluated dressing (UrgoFit, Laboratoires Urgo, France) in 23 centres in France. Eligible patients were adults with a cutaneous wound of acute or chronic origin or due to epidermolysis bullosa (EB) in the granulation stage. The primary endpoint was the relative wound area reduction (RWAR) at week 4. Secondary endpoints included wound closure rate and time-to-heal, as well as dressing change frequency, pain at dressing removal, local tolerance and acceptability of the dressing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 78 adult patients (23\u201395 years old) were treated with the dressing over a period of 24\u00b18 days. Wound aetiologies included: postoperative or traumatic finger wounds; skin graft donor sites; dermabrasions\/skin tears; burns; leg ulcers (LUs) of predominantly venous origin; a stage 3 pressure injury; and EB lesions. The median RWAR at week 4 was 98.2% (ranging between 61.5\u2013100.0%, depending on wound types). Complete closure was achieved in 49% of patients (59% in acute wounds, 60% in EB lesions and 16% in chronic wounds) with a median time-to-heal of 16.5 days (ranging between 14.5\u201327.0 days, depending on wound types). Half of LUs reached a RWAR \u226540% at week 4, a predictive indicator of complete wound healing at week 24. Dressings were changed every 2\u00b11 days on average (and left in place for a maximum of 10 days). Since the first application, the dressing was judged by healthcare professionals (HCPs) to be \u2018very easy\u2019 or \u2018easy\u2019 to apply on 96% of wounds, with a \u2018very good\u2019 or \u2018good\u2019 conformability to 94% of wound beds. Similar results were reported in cases of finger\/hand wounds. Since the first week of treatment, the dressing removal was also judged \u2018very easy\u2019 or \u2018easy\u2019 in 95\u201398% of the cases, protecting and preserving newly formed tissue in 100% of cases. At the first follow-up visit, patients reported the dressing changes to be painless in 95% of cases. This represented a significant improvement over the previous dressings they received (p&lt;0.0001). In all, seven non-serious adverse events related to the dressing were reported during the study period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>In this clinical trial, the innovative mesh-free TLC dressing was shown to promote wound healing, to be well tolerated and well accepted by patients and HCPs, in line with the evidence available on other TLC dressings; however, its enhanced conformability may provide an additional benefit for the management of wounds.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.12968\/jowc.2025.0356","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T15:10:08Z","timestamp":1760541008000},"page":"898-909","source":"Crossref","is-referenced-by-count":1,"title":["An innovative, highly conformable, mesh-free healing matrix dressing: results of a clinical trial"],"prefix":"10.12968","volume":"34","author":[{"given":"Sylvie","family":"Meaume","sequence":"first","affiliation":[{"name":"Geriatric Department, Rothschild University Hospital, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franck","family":"Duteille","sequence":"additional","affiliation":[{"name":"Plastic and Reconstructive Surgery and Burns Department, H\u00f4tel-Dieu University Hospital, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Bourrat","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Saint-Louis Hospital, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florent","family":"Sala","sequence":"additional","affiliation":[{"name":"Vascular Surgery Department, Montr\u00e9al Polyclinic, Carcassonne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Beatrix","sequence":"additional","affiliation":[{"name":"General and Oncology Surgery Department, Lyon Sud Hospital HCL, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Blaise","sequence":"additional","affiliation":[{"name":"Department of Vascular Medicine, Albert Michalon University Hospital, Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azeddine","family":"Addala","sequence":"additional","affiliation":[{"name":"Angiology Private Practice, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliette","family":"Mazereeuw-Hautier","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Reference Centre for Rare Skin Diseases, CHU de Toulouse, University Paul Sabatier, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rapha\u00ebl","family":"Sinna","sequence":"additional","affiliation":[{"name":"Department of Plastic, Reconstructive and Aesthetic Surgery, Amiens University Hospital, Amiens, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Leger","sequence":"additional","affiliation":[{"name":"Vascular Medecine Department, Pasteur Clinic, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Malloizel","sequence":"additional","affiliation":[{"name":"Vascular Medecine Department, Rangueil University Hospital, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e9mence","family":"Tumba","sequence":"additional","affiliation":[{"name":"Clinical Research Department, Laboratoires Urgo, Chen\u00f4ve, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2354-9085","authenticated-orcid":false,"given":"Laetitia","family":"Thomassin","sequence":"additional","affiliation":[{"name":"Medical Affairs Department, Laboratoires Urgo, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Tacca","sequence":"additional","affiliation":[{"name":"Clinical Research Department, Laboratoires Urgo, Chen\u00f4ve, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hester","family":"Colboc","sequence":"additional","affiliation":[{"name":"Geriatric Department, Rothschild University Hospital, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5130","reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.12968\/bjon.2023.32.Sup20.S12"},{"key":"e_1_3_3_2_2","unstructured":"Dowsett C Pagnmenta F Fletcher J et al. 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